Nutrición Hospitalaria 00978 / http://dx.doi.org/10.20960/nh.978
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Trabajo Original

A new fructose-free, resistant-starch type iv-enriched enteral formula improves glycaemic control and cardiovascular risk biomarkers when administered for six weeks to elderly diabetic patients


María Dolores Mesa-García, Cruz Erika Garcia-rodriguez, Maria De La Cruz Rico, Concepcion Maria Aguilera, Milagros Perez-rodriguez, Antonio Jesús Pérez-de-la-cruz, Ángel Gil

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Background: Reducing the dietary glycaemic response has been proposed as a way to reduce the risk of diabetes complications.Objective:The aim of the present study was to evaluate the glycaemic control and cardiovascular risk biomarkers in fragile, elderly type 2 diabetes patients after the intake of a new fructose-free diabetes-specific formula enriched with resistant-starch type IV and high in monounsaturated fatty acids.Methods: Forty-one type 2 diabetes patients aged 78.9 ± 2.8 years were fed exclusively with an enteral diabetes-specific formula for 6 weeks. Data were collected at baseline and after 6 weeks of feeding. Carbohydrate and lipid metabolism and inflammatory and cardiovascular risk biomarkers were measured to evaluated the course of diabetes complications.Results: Blood glycated haemoglobin significantly decreased after the intervention (6.1 ± 0.1 vs. 5.8 ± 0.1 %; p< 0,045), as well as monocyte chemotactic protein-1 and soluble E-selectin (p < 0.05), while soluble vascular cell adhesion molecule and plasminogen activator inhibitor-1 tended to decrease from baseline to 6 weeks (p = 0.084 and p = 0.05, respectively).Conclusion: The new product improves glycaemic control and cardiovascular risk without altering lipid metabolism, which is useful for the prevention of diabetic complications. Longer intervention studies are needed in order to validate these results in a larger population.

Palabras Clave: Diabetes mellitus type 2. Cardiovascular risk. Enteral nutrition. Glycaemic control. Glycated haemoglobin. Resistant-starch type IV.



Cesur, Fatih, Seçkiner, Selda, Kucukerdonmez, Ozge, Cagindi, Ozlem, Saygili, Lütfiye Füsun, Meseri, Reci (2023) Can Enzyme‐Resistant Starch Snack Prevent Blood Glucose Fluctuations? A Pilot Trial in Patients with Insulin‐Treated Type 2 Diabetes. Starch - Stärke
Rashed, Aswir Abd, Saparuddin, Fatin, Rathi, Devi-Nair Gunasegavan, Nasir, Nur Najihah Mohd, Lokman, Ezarul Faradianna (2022) Effects of Resistant Starch Interventions on Metabolic Biomarkers in Pre-Diabetes and Diabetes Adults. Frontiers in Nutrition
Lokman, Ezarul Faradianna, Bugam, Sal Hazreen, Ibrahim, Aina Shafiza, Yunus, Nurleyna, Mansor, Fazliana, Balasubramaniam, Vimala, Mohamad, Khairul Mirza, Md Lazim, Rabizah, Awang Seruji, Awang Zulfikar Rizal (2023) Postprandial glucose-lowering effects by sago (Metroxylon sagu Rottb.) resistant starch in spontaneously type 2 diabetes, Goto-Kakizaki rat. Nutrition and Health
Zhu, Mingwei, Cui, Hongyuan, Chen, Wei, Jiang, Hua, Li, Zijian, Dong, Birong, Chen, Huaihong, Wang, Yan, Tang, Yun, Hu, Yu, Sun, Jianqin, Chen, Yanjin, Tao, Yexuan, Zhou, Suming, Cao, Weixin, Wei, Junmin (2020) Guidelines for parenteral and enteral nutrition in geriatric patients in China. AGING MEDICINE
Mao, Yongjun, Wu, Jianqing, Liu, Gongxiang, Yu, Yao, Chen, Bo, Liu, Jia, Wang, Jianye, Yu, Pulin, Zhang, Cuntai, Wu, Jinhui (2022) Chinese expert consensus on prevention and intervention for the elderly with malnutrition (2022). AGING MEDICINE
Costa, Edna S., França, Carolina N., Fonseca, Francisco A. H., Kato, Juliana T., Bianco, Henrique T., Freitas, Thiago T., Fonseca, Henrique A. R., Figueiredo Neto, Antonio Martins, Izar, Maria Cristina (2019) Beneficial effects of green banana biomass consumption in patients with pre-diabetes and type 2 diabetes: a randomised controlled trial. British Journal of Nutrition
Chanmuang, Saoraya, Nguyen, Quynh-An, Kim, Hyun-Jin (2022) Current Research on the Effects of Non-Digestible Carbohydrates on Metabolic Disease. Applied Sciences

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