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Oxygen pulse as a protective factor of insulin resistance in sedentary women with overweight or obesity

Luis Gonzalez Rojas, Johana Soto Sánchez, Marcelo Cano Capellacci, Rodrigo Muñoz Claro, Javiera Cancino Ramírez

Background: obesity is associated with insulin resistance (IR). Through exercise, insulin resistant obese patients can effectively improve theircardiorespiratory fitness (CRF). The effect of exercise on patients CRF can be determined by oxygen pulse (PO2) analysis. Despite its usefulness, there is limited literature on PO2 analysis in patients with obesity and insulin resistance.Objective: the goal of the present study is to evaluate the relation between PO2 and IR in sedentary obese women.Methods: fifty-five women were submitted to a maximal exercise test for evaluation of maximal oxygen consumption and PO2. The subjects with a homeostatic model assessment of IR index greater or equal to 2.5 were considered as insulin-resistant (IR). Participants were divided into two groups, IR group (n = 35) and non-IR group (n = 20).Results: the IR group had lower values of PO2 relative to body weight (11.0 ± 1.7 versus 12.6 ± 1.4 ml∙kg∙beats-1, p = 0.001) and relative to lean mass (21.7 ± 2.9 versus 23.2 ± 2.8 ml∙kg∙beats-1, p = 0.038) than non-IR group. No statistical differences were found in maximal oxygen consumption between the groups (non-IR = 1.53 ± 0.27 l∙min-1, IR = 1.51 ± 0.28 l∙min-1; p = 0.386). PO2 relative to body weight and HOMA-IR was inversely correlated (p < 0.001; r = -0.465). Logistic regression analysis showed an association between PO2 relative to weight (p = 0.001, OR = 0.47) and fat free mass (p = 0.01, OR = 0.73), both models adjusted by age.Conclusions: this study demonstrates a relation between HOMA-IR and PO2. Our results suggest that PO2 could be a protective factor against insulin resistance.

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