Nutrición Hospitalaria 00384 / http://dx.doi.org/10.20960/nh.384

Trabajo Original

Relation of trp64arg polymorphism of beta 3 adrenoreceptor gene with metabolic syndrome and insulin resistance in obese women

Daniel de Luis Román, David Primo, Olatz Izaola, Rocio Aller

VOLUMEN 34, NÚM. 2, marzo-abril (2017), PAG. 383-388

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Background and aim: Trp64Arg variant in beta 3 adrenoreceptor has been reported to be associated with increased body weight and insulin resistance. These risk factors are the ones that make up the so-called metabolic syndrome. The aim of our study was to investigate the relationship between metabolic syndrome and Trp64Arg polymorphism in the beta3 adrenoreceptor gene in obese women.Methods: A population of 531 obese women was analyzed in cross-sectional survey. A bioimpedance, blood pressure, a serial assessment of nutritional intake with 3 days written food records and biochemical analysis were performed. Genotype of beta 3 adrenoreceptor gene polymorphism (Trp64Arg) was studied.Results: Prevalence of metabolic syndrome (MS) with ATP III definition was 47.1% (250 patients) and 52.9% patients without MS (n = 281 patients). Prevalence of beta 3 genotypes was similar in patients with metabolic syndrome (87.6% wild genotype and 12.4% mutant genotype) and without metabolic syndrome (87.9% wild genotype and 12.1% mutant genotype). Insulin and HOMA levels were higher in patients with mutant genotype than wild type, in patients with and without metabolic syndrome.Conclusion: In mutant group of beta3 adrenoreceptor gene patients have higher insulin and HOMA levels than wild type group, without relation with metabolic syndrome.

Palabras Clave: Adipocytokines. Females. Insulin resistance. Metabolic síndrome. Trp64Arg beta 3 adrenoreceptor. Obesity.

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