Acceso gestor editorial

Lifestyle and vitamin d dosage in women with breast cancer

Catarina Maria Oliveira Sediyama , Manoela Maciel Dos Santos Dias , Milene Cristine Pessoa , Andréia Ribeiro Queiroz , Lara Gomes Suhett , Renata Nascimento Freitas , Sérgio Oliveira De Paula , Maria Do Carmo Gouveia Peluzio

Resumen

Introduction: The prevention strategy of breast cancer is still the key factor for early diagnosis and the most effective method for tracking the disease.Objective: This study aimed to evaluate the association vitamin D level with breast cancer in women.Methods: This hospital case-control study was conducted with 181 women with breast cancer and 197 healthy controls. Vitamin D status, calcium, phosphorus and PTH serum dosage and data collection related to lifestyle and patient’s history, besides anthropometric measurements were performed. Univariate analysis (Chi-square and raw odds ratio) and multivariate analysis were performed through multivariate logistic regression.Results: This study shows a higher value of vitamin D in health controls (26.9 mg/dL) than in breast cancer women (24.8 mg/dL). Higher numbers of women with sufficient vitamin D status (34.85%) were found in control group than cancer group. Using the multiple logistic regression model, the family history of breast cancer (OR 36.37, 95%CI 4.75-278.50) and menopause (OR 5.17, 95% CI 2.72-9.80) had a direct association with breast cancer, while the level of vitamin D (OR 0.95, 95%CI 0.91-0.99) and moderate physical activity (OR 0.31, 95%CI 0.10-0.93) maintained the inverse associations with the disease.Conclusion: Vitamin D status and the practice of moderate physical activity were considered protective factors for breast cancer. However, menopause and family history of breast cancer were considered a risk factor for breast cancer.

Palabras Clave

Breast cancer. Vitamin D. Menopause. Physical activity. Case-control study.


Texto Completo: PDF (ENGLISH)



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