Nutrición Hospitalaria 00795 / http://dx.doi.org/10.20960/nh.795
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Trabajo Original

Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease


Lisiane Lopes Da Conceição, Mariana De Moura Dias, Milene Cristine Pessoa, Geórgia Das Graças Pena, Maria Carolina Santos Mendes, Cristiane Vilas Boas Neves, Helen Hermana Miranda Hermsdorff, Renata Nascimento Freitas, Maria Do Carmo Gouveia Peluzio

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Introduction: Breast cancer is the second most common cancer in the world, and the most frequent cancer among women. Moreover, there are factors that influence the risk for breast cancer including the age, genetic and endocrine factors, and lifestyle.Objectives: To evaluate the consumption of fatty acids; compare the fatty acids composition in the breast adipose tissue of women with breast cancer and benign breast disease as well as potential risk factors; and describe the genotypic frequency of the Pro12Ala PPARγ polymorphism.Material and methods: A hospital-based case-control study was conducted including incident cases (n= 38 breast cancer; n= 75 benign breast disease; n= 166 control). Lifestyle features, socioeconomic issues, dietary intake, anthropometry, and blood and tissue data were assessed. Results: No differences were observed for fatty acids intake. Interestingly, lauric acid (p = 0.001), myristic acid (p = 0.036), stearic acid (p = 0.031), and total saturated fatty acids (SFAs) (p = 0.048) had lower concentrations in BC than in BBD women, while palmitoleic acid (p = 0.022), erucic acid (p = 0.002), total monounsaturated fatty acids (MUFAs) (p = 0.039) and oleic acid/stearic acid ratio (p = 0.015) increased. There was no significant association between PPARγ polymorphism and studied groups (p = 0.977). The age at first full pregnancy (p = 0.004) was significantly associated with the development BC, whereas BMI (p = 0.005); percentage of body fat (p = 0.024); physical activity (p = 0.036); and age at menarche (p = 0.008), at first full pregnancy (p < 0.001), and of first mammogram (p = 0.018) were significantly associated with the development of BBD.Conclusion: The results suggest a different fatty acids composition of breast adipose tissue, a biomarker of long-term dietary intake, particularly for SFAs, MUFA and 18: 1 n-9/18: 00 ratio. Our findings also show that are differences in the factors related to the development of BC and BBC.

Palabras Clave: Fatty acids. Breast cancer. Benign breast disease. PPARγ. Dietary intake.



Newell, Marnie, Ghosh, Sunita, Goruk, Susan, Pakseresht, Mohammedreza, Vena, Jennifer E, Dummer, Trevor J B, Field, Catherine J (2021) A Prospective Analysis of Plasma Phospholipid Fatty Acids and Breast Cancer Risk in 2 Provinces in Canada. Current Developments in Nutrition
Verma, Poonam, Naik, Sanjukta, Nanda, Pranati, Banerjee, Silvi, Naik, Satyanarayan, Ghosh, Amit (2020) In Vitro Anticancer Activity of Virgin Coconut Oil and its Fractions in Liver and Oral Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry
Schilling, Marla Presa Raulino, Silva, Ilce Ferreira da (2020) Family history of breast cancer and risk of benign breast diseases: an integrative literature review. Mastology
Xiao, Qian, Xia, Min, Tang, Weijian, Zhao, Hu, Chen, Yajun, Zhong, Jing (2024) The lipid metabolism remodeling: A hurdle in breast cancer therapy. Cancer Letters
Li, Hui, Wang, Xianling, Tang, Jun, Zhao, Haibo, Duan, Min (2019) Decreased expression levels of ELOVL6 indicate poor prognosis in hepatocellular carcinoma. Oncology Letters
Sefidabi, Reyhaneh, Alizadeh, AliReza, Alipour, Sadaf, Omranipour, Ramesh, Shahhoseini, Maryam, Izadi, Amin, Vesali, Samira, Moini, Ashraf (2023) Fatty acid profiles and Delta9 desaturase (stearoyl-CoA desaturase; SCD 1) expression in adipose tissue surrounding benign and malignant breast tumors. Heliyon

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