Nutrición Hospitalaria 00949 / http://dx.doi.org/10.20960/nh.949

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Incidence of high body mass index in critically ill cancer patients

Silvio Antonio Ñamendys-silva, Humberto Guevara-garcía, Juan A. Arredondo-armenta, Mireya Barragán-dessavre, Andoreni R. Bautista-ocampo, Francisco J. García-guillén, Bertha M. Córdova-sánchez, Abelardo Meneses García, Ángel Herrera-gómez

VOLUMEN 34, NÚM. 4, julio-agosto (2017), PAG. 856-862

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Objective: The aims of this study were to describe the incidence of obesity and overweight in critically ill cancer patients, and to evaluate the clinical characteristics and Intensive Care Unit (ICU) outcomes of critically ill cancer patients with obesity and overweight.Methods: An observational cohort study. There were no interventions. Results: During the study period, 483 critically ill cancer patients were admitted to ICU, and 59.2% of them (258 patients) had high body mass index (BMI). Comparing the groups of patients with BMI < 25 kg/m2 and ≥ 25 kg/m2, we observed that those with BMI ≥ 25 kg/m2 were older at the time of admission to the ICU. The global mortality in ICU was of 22.4%. ICU mortality was similar between patients with BMI < 25 kg/m2 and ≥ 25 kg/m2 (21.3% versus 23.0%, p = 0.649). Univariate analysis indicated that the following five factors were associated with ICU death in patients with BMI ≥ 25 kg/m2 as the outcome variable of interest: age, sepsis, invasive mechanical ventilation, type 2 diabetes, ≥ two organ failures. Multivariate analysis identified ≥ two organ failures as independent prognostic factor of ICU death.Conclusion: Critically ill cancer patients have a high incidence of high BMI; approximately six of every ten patients admitted to the ICU with a serious condition are overweight or show several degrees of obesity. The ICU mortality of the patients with a body mass index < 25 kg/m2 and ≥ 25 kg/m2 was similar. The independent prognostic factor of ICU death in critically ill patients with a BMI ≥ 25 kg/m2 was the number of organ dysfunctions, especially when two or more organs were affected.

Palabras Clave: Incidence. High body mass index. Critically ill cancer patients. Intensive Care Unit. Obesity. Outcome.

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References

http://www.who.int/mediacentre/factsheets/fs311/es/ (Accessed 08 January 2017).

http://www.dof.gob.mx/nota_detalle.php?codigo=5154226&fecha=04/08/2010 (Accessed 08 January 2017).

http://ensanut.insp.mx/informes/ENSANUT2012ResultadosNacionales.pdf (Accessed 08 January 2017).

Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303-10.
DOI: 10.1097/00003246-200107000-00002

Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013;309:71-82.
DOI: 10.1001/jama.2012.113905

Institute for Health Metrics and Evaluation. Global Burden of Disease (GBD2010). http://vizhub.healthdata.org/gbd-compare/ (Accessed 08 January 2017).)

Cottam DR, Mattar SG, Barinas-Mitchell E, Eid G, Kuller L, Kelley DE, et al. The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss. Obes Surg. 2004;14:589-600.
DOI: 10.1381/096089204323093345

Vachharajani V, Vital S. Obesity and sepsis. J Intensive Care Med. 2006;21:287-95.
DOI: 10.1177/0885066606290670

Vachharajani V, Russell JM, Scott KL, Conrad S, Stokes KY, Tallam L, et al.: Obesity exacerbates sepsis-induced inflammation and microvascular dysfunction in mouse brain. Microcirculation. 2005;12:183-94.
DOI: 10.1080/10739680590904982

Singer G, Stokes KY, Terao S, Granger DN. Sepsis-induced intestinal microvascular and inflammatory responses in obese mice. Shock 2009;31, 275-9

Teoh H, Quan A, Bang KW, Wang G, Lovren F, Vu V, et al.: Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality. Am J Physiol Endocrinol Metab. 2008;295:E658-64.

Roberts DL, Dive C, Renehan AG. Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med 2010;61:301–16
DOI: 10.1146/annurev.med.080708.082713

Calle E, Rodriguez C, Walke-Thurmoid K, Thun MJ. Overweight obesity and mortality from cáncer is a prospectively studied cohort of U.S. adults. N Engl J Med 2003:348, 1625–38

Kuperman EF, Showalter JW, Lehman EB, Leib AE, Kraschnewski JL. The impact of obesity on sepsis mortality: a retrospective review. BMC Infect Dis 2013;13: 377
DOI: 10.1186/1471-2334-13-377

Wacharasint P, Boyd JH, Russell JA, Walley KR. One size does not fit all in severe infection: obesity alters outcome, susceptibility, treatment, and inflammatory response. Crit Care 2013:17, R122

Arabi YM, Dara SI, Tamim HM, Rishu AH, Bouchama A, Khedr MK, Feinstein D, et al. Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study. Crit Care 2013:17, R72

Huttunen R, Laine J, Lumio J, Vuento R, Syrjanen J. Obesity and smoking are factors associated with poor prognosis in patients with bacteraemia. BMC Infect Dis 2007;7:13
DOI: 10.1186/1471-2334-7-13

Gaulton TG, Weiner MG, Morales KH, Gaieski DF, Mehta J, Lautenbach E. The effect of obesity on clinical outcomes in presumed sepsis: a retrospective cohort study. Intern Emerg Med 2014:9, 213–21

Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, et al. Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315:762-74
DOI: 10.1001/jama.2016.0288

Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II. A severity of disease classification system. Crit Care Med 1985;13:818–29
DOI: 10.1097/00003246-198510000-00009

Vincent JL, de Mendonça A, Cantraine F, Moreno R, Takala J, Suter PM, et al.: Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med 1998;26:1793-800
DOI: 10.1097/00003246-199811000-00016

Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, et al.: The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996;22:707–710
DOI: 10.1007/BF01709751

Namendys-Silva SA, Silva-Medina MA, Vásquez-Barahona GM, Baltazar-Torres JA, Rivero-Sigarroa E, Fonseca-Lazcano JA, et al. Application of a modified sequential organ failure assessment score to critically ill patients. Braz J Med Biol Res 2013;46:186–193
DOI: 10.1590/1414-431X20122308

Kiraly L, Hurt RT, Van Way CW 3rd.The outcomes of obese patients in critical care. JPEN J Parenter Enteral Nutr 2011;35:29S-35S

Prescott HC, Chang VW, O'Brien JM Jr, Langa KM, Iwashyna TJ. Obesity and 1-year outcomes in older Americans with severe sepsis. Crit Care Med 2014;42:1766–74
DOI: 10.1097/CCM.0000000000000336

Wurzinger B, Dünser MW, Wohlmuth C, Deutinger MC, Ulmer H, Torgersen C, et al.: The association between body-mass index and patient outcome in septic shock: a retrospective cohort study. Wien Klin Wochenschr 2010:122;31–6

Ostchega Y, Hughes JP, Terry A, Fakhouri TH, Miller I. Abdominal obesity, body mass index, and hypertension in US adults: NHANES 2007-2010. Am J. Hypertens 2012;25:1271-8

Sharp JT, Henry JP, Sweany SK, Meadows WR, Pietras RJ. The total work of breathing in normal and obese men. J Clin Invest 1964;43:728–39
DOI: 10.1172/JCI104957

Pelosi P1, Croci M, Ravagnan I, Tredici S, Pedoto A, Lissoni A, et al.The effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesia. Anesth Analg 1998;87:654–60

Behazin N, Jones SB, Cohen RI, Loring SH. Respiratory restriction and elevated pleural and esophageal pressures in morbid obesity. J Appl Physiol (1985) 2010;108:212–8
DOI: 10.1152/japplphysiol.91356.2008

Suratt PM, Wilhoit SC, Hsiao HS, Atkinson RL, Rochester DF. Compliance of chest wall in obese subjects. J Appl Physiol 1984;57:403–7
DOI: 10.1152/jappl.1984.57.2.403

Salome CM, King GG, Berend N. Physiology of obesity and effects on lung function. J Appl Physiol 2010;108:206–11
DOI: 10.1152/japplphysiol.00694.2009

Gong MN, Bajwa EK, Thompson BT, Christiani DC. Body mass index is associated with the development of acute respiratory distress syndrome. Thorax 2010;65:44-50
DOI: 10.1136/thx.2009.117572

Gruberg L, Weissman NJ, Waksman R, Fuchs S, Deible R, Pinnow EE, et al. The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox? J Am Coll Cardiol 2002;39:578–84

Gonzalez MC, Pastore CA, Orlandi SP, Heymsfield SB. Obesity paradox in cancer: new insights provided by body composition. Am J Clin Nutr 2014;99:999–1005
DOI: 10.3945/ajcn.113.071399

Niedziela J, Hudzik B, Niedziela N, Gąsior M, Gierlotka M, Wasilewski J, et al. The obesity paradox in acute coronary syndrome: a meta- analysis. Eur J Epidemiol 2014;29:801-812
DOI: 10.1007/s10654-014-9961-9

Kalantar-Zadeh K, Streja E, Kovesdy CP, Oreopoulos A, Noori N, Jing J, et al. The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysis. Mayo Clin Proc 2010;85:991-1001
DOI: 10.4065/mcp.2010.0336

Curtis JP, Selter JG, Wang Y. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med 2005;165:55–61
DOI: 10.1001/archinte.165.1.55

Nie W, Zhang Y, Jee SH, Jung KJ, Li B, Xiu Q. Obesity survival paradox in pneumonia: a meta-analysis. BMC Med. 2014;12:61
DOI: 10.1186/1741-7015-12-61

Aguilar-Ponce JL, Villarreal-Garza C, Lara-Medina FU, Olvera-Caraza D, Alvarado Miranda A, et al. Overweight and obesity as poor prognostic factors in locally advanced breast cancer patients. Breast Cancer Res Treat. 2014;146:183-8
DOI: 10.1007/s10549-014-2977-8

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