Trabajo Original

Effect of fish and olive oil on mitochondrial atpase activity and membrane fluidity in patients with relapsing-remitting multiple sclerosis treated with interferon beta 1-b

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Erandis D. Torres-sánchez, Fermín P. Pacheco-moisés, Miguel A. Macias-islas, Eddic W. Morales-sánchez, Viridiana Ramírez-ramírez, Alfredo J. Celis De La Rosa, Margarita Cid-hernández, Tanya E. Sorto-gómez, Genaro G. Ortiz

Background: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with increased oxidative stress (OS) and mitochondrial alterations. Fish oil consumption has neuroprotective, antioxidant and anti-inflammatory effects in patients with relapsing-recurrent MS (RR-MS).Objective: To evaluate changes in the hydrolytic activity of ATP synthase and mitochondrial membrane fluidity in patients with RR-MS who receive fish oil or olive oil as a dietary supplement.Methods: Clinical, controlled, randomized, double-blind trial. Patients consumed fish oil or olive oil for one year. The hydrolytic activity of ATPase and the fluidity of the mitochondrial membrane of platelets were quantified.Results: In patients with RR-MS, a decrease in the fluidity of mitochondrial membranes and an increase in the hydrolytic activity of ATP synthase was observed in comparison with healthy controls. After 6 or 9 months of treatment with fish oil or olive oil, respectively, these values were normalized.Conclusion: The consumption of fish oil and olive oil increases the fluidity of the mitochondrial membranes and decreases the catabolic activity of ATP synthase in platelets from patients with RR-MS.

Palabras Clave: Multiple sclerosis;mitochondrial ATPase;membranal fluidity;olive oil;fish oil.

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