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Multicenter study of parenteral nutrition in non-critically ill elderly patients compared to younger patients - study iaios-pn (incidence and assessment of iatrogenesis in older subjects receiving parenteral nutrition)

Javier Mateu-de Antonio, David Berlana, Montserrat Pons-bussom, Maria B. Badia-tahull, María Teresa Miana-mena, Beatriz Martínez-castro, Neus Sunyer-esquerrà, Mónica Sanmartin-suñer, Juan González-valdivieso, Elisabet Leiva-badosa, Eva Martínez-bernabé, Anna Murgadella-sancho, Nuria Mirerachs-aranda, Anna Vila-bundó, Jordi Fernández-morató, María Teresa Vitales-farrero

Objective: this study assessed the incidence of hyperglycemia, hypertriglyceridemia, and liver function test (LFT) alterations among patients older and younger than 65 years receiving parenteral nutrition (PN). A secondary objective was to compare the incidence of any of these three events.Material and methods: inclusion criteria were non-critically ill adult inpatients receiving PN for ≥ 7 days in 15 hospitals in Spain. Exclusion criteria were hyperglycemia, hypertriglyceridemia, LFT alterations, sepsis, shock, pancreatic/hepatobiliary surgery, renal failure, diabetes mellitus (DM) type 1, insulin-treated DM type 2, acute DM complications, or obesity prior to PN. Patients were classified into groups YOUNG (aged 35-64) and OLD (aged 65-95).Results: this study recruited 200 patients. Group YOUNG included 63 (31.5%) patients and OLD, 137 (68.5%). Hyperglycemia appeared in 37 (18.5%) patients, eight (12.7%) in group YOUNG and 29 (21.2%) in group OLD (p = 0.174). Hypertriglyceridemia appeared in only one (0.7%) patient. LFT alterations appeared in 141 (70.5%) patients, 44 (69.8%) in group YOUNG and 97 (70.8%) in group OLD (p = 1.000). The model for hyperglycemia included DM type 2, previous surgical procedure, and use of hyperglycemia-inducing medications. The model for LFT alteration included previous surgical procedure, amount of lipids and amino acids, medications causing LFT alterations and a trend for age group. The model for any event included surgical procedure, DM type 2, and medications causing alterations.Conclusion: patients of ≥ 65 years receiving PN had similar incidences of hyperglycemia, hypertriglyceridemia, and LFT alterations as younger patients. Additionally, older patients had trends toward lower LFT alterations.

Palabras Clave: Aged; Drug-Induced Liver Injury; Hyperglycemia; Hypertriglyceridemia; Liver Disease; Parenteral Nutrition

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