Nutrición Hospitalaria 01441 / http://dx.doi.org/10.20960/nh.1441
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Trabajo Original

Visceral adiposity increases the risk of breast cancer: a case-control study


Jordana Carolina Marques Godinho-mota, Karine Anusca Martins, Larissa Vaz-gonçalves, João Felipe Mota, Leonardo Ribeiro Soares, Ruffo Freitas-junior

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Introduction: in recent decades, lifestyle changes in women involving physical inactivity, insulin resistance and body fat distribution have been associated with an increase in breast cancer.Objective: to assess whether insulin resistance, lipid profile, and visceral adiposity are associated with increased risk of breast cancer.Methods: a hospital-based case control study was conducted with 116 women newly diagnosed with breast cancer and 226 controls. Body mass index, waist circumference, total cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), very-low-density lipoproteins (VLDL), triglycerides, glycated hemoglobin, HOMA-IR, HOMA-β, lipid accumulation product (LAP), and visceral adiposity index (VAI) were assessed. Logistic regression was adjusted for body mass index and age to quantify the association between breast cancer risk and insulinresistance, dyslipidemias, and visceral adiposity.Results: the case group had higher insulin resistance (p < 0.001), LAP (p = 0.012), and VAI (p = 0.004), and lower concentrations of HDL (p = 0.024) and HOMA-β(p = 0.010) compared to the control. Insulin resistance (OR = 3.00, 95% CI: 1.75-5.17, p < 0.001) and higher VAI (OR = 1.91, 95% CI: 1.17-3.13, p = 0.01) were associated with breast cancer, whereas the highest concentration of HDL reduces the chances of cancer by 53% (95% CI: 0.32-0.86, p = 0.026). In the multivariate analysis, only LAP and VAI were associated to breast cancer.Conclusions: visceral fat accumulation increases the risk of breast cancer.

Palabras Clave: breast cancer; insulin resistance; visceral adiposity; lipid profile



(2019) Molecular Links between Central Obesity and Breast Cancer. International Journal of Molecular Sciences
Ramírez-Marrero, F. A., Nazario, C. M., Rosario-Rosado, R. V., Schelske-Santos, M., Mansilla-Rivera, I., Nie, J., Hernández-Santiago, J., Freudenheim, J. L. (2022) Anthropometric measures and breast cancer risk among Hispanic women in Puerto Rico. Cancer Causes & Control
Wang, Yu-Chiao, Lin, Ching-Hung, Huang, Shih-Pei, Chen, Mingchih, Lee, Tian-Shyug (2022) Risk Factors for Female Breast Cancer: A Population Cohort Study. Cancers
Barrea, Luigi, Muscogiuri, Giovanna, Modica, Roberta, Altieri, Barbara, Pugliese, Gabriella, Minotta, Roberto, Faggiano, Antongiulio, Colao, Annamaria, Savastano, Silvia (2021) Cardio-Metabolic Indices and Metabolic Syndrome as Predictors of Clinical Severity of Gastroenteropancreatic Neuroendocrine Tumors. Frontiers in Endocrinology

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