Nutrición Hospitalaria 03342 /
Resumen| PDF (ENGLISH)

Trabajo Original

A prospective study in women: açaí (Euterpe oleracea Martius) dietary intake affects serum p-selectin, leptin, and visfatin levels

Melina Oliveira de Souza, Priscila Barbosa, Daniela Pala, Joana Ferreira Amaral, Ana Carolina Pinheiro Volp, Renata Nascimento de Freitas

Prepublicado: 2020-12-04
Publicado: 2021-02-16

Logo Descargas   Número de descargas: 12617      Logo Visitas   Número de visitas: 3912      Citas   Citas: 0


Background: açaí is the fruit of the palm tree Euterpe oleracea Martius, which is native to the Amazon region. This fruit has been extensively studied due to its potential effects on human health. Studies have also evaluated the potential effect of açaí on the inflammatory response, but there are still few studies that have assessed this property in humans. Objective: in this study we aimed to evaluate the effects of 200 g of açaí pulp consumption per day during four weeks on a rich panel of inflammatory biomarkers. Methods: a prospective nutritional intervention study was conducted on forty apparently healthy women who consumed 200 g of açaí pulp per day for four weeks. A panel of serum inflammatory markers were evaluated before and after the nutritional intervention, namely, cell adhesion molecules (ICAM-1, IVAM-1, P-selectin, MCP-1, and fractalkine), interleukins (IL-1β, IL-6, IL-8, IL-10, and IL-17) and adipokines (adiponectin, leptin, visfatin, and adipsin). The data were analyzed using paired Student's t-test to evaluate the effect of the intervention using PASW Statistics, version 17.0, and a p-value of < 0.05 was considered significant. Results: four weeks of açaí pulp consumption decreased p-selectin, leptin, and visfatin concentrations in the serum of the participating women. Conclusion: these results show that consumption of açaí pulp was able to modulate important biomarkers of the inflammatory process in apparently healthy women.

Palabras Clave: Açaí. Adipokines. Cell adhesion molecules. Euterpe oleracea Martius. Healthy women. Interleukin.

Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm 2010;2010.
DOI: 10.1155/2010/289645
Kansas GS. Selectins and their ligands: current concepts and controversies. Blood 1996;88(9):3259-87.
DOI: 10.1182/blood.V88.9.3259.bloodjournal8893259
Galkina E, Ley K. Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol 2007;27(11):2292-301.
DOI: 10.1161/ATVBAHA.107.149179
Vieira RAL, Nascimento de Freitas RN, Volp ACP. Adhesion molecules and chemokines; relation to anthropometric, body composition, biochemical and dietary variables. Nutr Hosp 2014;30(2):223-36.
Khodabandehlou K, Masehi-Lano JJ, Poon C, Wang J, Chung EJ. Targeting cell adhesion molecules with nanoparticles using in vivo and flow-based in vitro models of atherosclerosis. Exp Biol Med (Maywood) 2017;242(8):799-812.
DOI: 10.1177/1535370217693116
Huveneers S, Danen EH. Adhesion signaling - crosstalk between integrins, Src and Rho. J Cell Sci 2009;122(Pt 8):1059-69.
DOI: 10.1242/jcs.039446
Baker RG, Hayden MS, Ghosh S. NF-kappaB, inflammation, and metabolic disease. Cell Metab 2011;13(1):11-22.
DOI: 10.1016/j.cmet.2010.12.008
Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 2009;1(6):a001651.
DOI: 10.1101/cshperspect.a001651
Soory M. Nutritional antioxidants and their applications in cardiometabolic diseases. Infect Disord Drug Targets 2012;12(5):388-401.
DOI: 10.2174/187152612804142233
Islam MA, Alam F, Solayman M, Khalil MI, Kamal MA, Gan SH. Dietary Phytochemicals: Natural Swords Combating Inflammation and Oxidation-Mediated Degenerative Diseases. Oxid Med Cell Longev 2016;2016:5137431.
DOI: 10.1155/2016/5137431
Arablou T, Aryaeian N, Djalali M, Shahram F, Rasouli L. Association between dietary intake of some antioxidant micronutrients with some inflammatory and antioxidant markers in active Rheumatoid Arthritis patients. Int J Vitam Nutr Res 2019:1-8.
Schauss AG, Wu X, Prior RL, Ou B, Huang D, Owens J, et al. Antioxidant capacity and other bioactivities of the freeze-dried Amazonian palm berry, Euterpe oleraceae mart. (acai). J Agric Food Chem 2006;54(22):8604-10.
DOI: 10.1021/jf0609779
de Souza MO, Silva M, Silva ME, Oliveira Rde P, Pedrosa ML. Diet supplementation with acai (Euterpe oleracea Mart.) pulp improves biomarkers of oxidative stress and the serum lipid profile in rats. Nutrition 2010;26(7-8):804-10.
DOI: 10.1016/j.nut.2009.09.007
Schreckinger ME, Lotton J, Lila MA, de Mejia EG. Berries from South America: a comprehensive review on chemistry, health potential, and commercialization. J Med Food 2010;13(2):233-46.
DOI: 10.1089/jmf.2009.0233
Wong DYS, Musgrave IF, Harvey BS, Smid SD. Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro. Neuroscience Letters 2013;556:221-26.
DOI: 10.1016/j.neulet.2013.10.027
Barbosa PO, Pala D, Silva CT, de Souza MO, do Amaral JF, Vieira RA, et al. Acai (Euterpe oleracea Mart.) pulp dietary intake improves cellular antioxidant enzymes and biomarkers of serum in healthy women. Nutrition 2016;32(6):674-80.
DOI: 10.1016/j.nut.2015.12.030
Pala D, Barbosa PO, Silva CT, de Souza MO, Freitas FR, Volp ACP, et al. Acai (Euterpe oleracea Mart.) dietary intake affects plasma lipids, apolipoproteins, cholesteryl ester transfer to high-density lipoprotein and redox metabolism: A prospective study in women. Clin Nutr 2018;37(2):618-23.
DOI: 10.1016/j.clnu.2017.02.001
Sarria B, Martinez-Lopez S, Sierra-Cinos JL, Garcia-Diz L, Mateos R, Bravo-Clemente L. Regularly consuming a green/roasted coffee blend reduces the risk of metabolic syndrome. Eur J Nutr 2018;57(1):269-78.
DOI: 10.1007/s00394-016-1316-8
Schauss AG, Wu X, Prior RL, Ou B, Patel D, Huang D, et al. Phytochemical and nutrient composition of the freeze-dried amazonian palm berry, Euterpe oleraceae mart. (acai). J Agric Food Chem 2006;54(22):8598-603.
DOI: 10.1021/jf060976g
Lunn J, Theobald HE. The health effects of dietary unsaturated fatty acids. Nutr Bull 2006;31(3):178-224.
DOI: 10.1111/j.1467-3010.2006.00571.x
Calder PC. The relationship between the fatty acid composition of immune cells and their function. Prostaglandins Leukot Essent Fatty Acids 2008;79(3-5):101-8.
DOI: 10.1016/j.plefa.2008.09.016
Rallidis LS, Kolomvotsou A, Lekakis J, Farajian P, Vamvakou G, Dagres N, et al. Short-term effects of Mediterranean-type diet intervention on soluble cellular adhesion molecules in subjects with abdominal obesity. Clin Nutr ESPEN 2017;17:38-43.
DOI: 10.1016/j.clnesp.2016.11.002
Rostami H, Samadi M, Yuzbashian E, Zarkesh M, Asghari G, Hedayati M, et al. Habitual dietary intake of fatty acids are associated with leptin gene expression in subcutaneous and visceral adipose tissue of patients without diabetes. Prostaglandins Leukot Essent Fatty Acids 2017;126:49-54.
DOI: 10.1016/j.plefa.2017.09.010
Neida S, Elba S. Characterization of the acai or manaca (Euterpe oleracea Mart.): a fruit of the Amazon. Arch Latinoam Nutr 2007;57(1):94-8.
U.S. Department of Agriculture, U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2010. 7th ed. Washington, DC: U.S. 2005: Government Printing Officer; 2010.
Dreher ML. Whole Fruits and Fruit Fiber Emerging Health Effects. Nutrients 2018;10(12):1833.
DOI: 10.3390/nu10121833
Ma Y, Hebert JR, Li W, Bertone-Johnson ER, Olendzki B, Pagoto SL, et al. Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study. Nutrition 2008;24(10):941-9.
DOI: 10.1016/j.nut.2008.04.005
Yang X, Nakamoto M, Shuto E, Hata A, Aki N, Shikama Y, et al. Associations between intake of dietary fermented soy food and concentrations of inflammatory markers: a cross-sectional study in Japanese workers. J Med Invest 2018;65(1.2):74-80.
DOI: 10.2152/jmi.65.74
King DE. Dietary fiber, inflammation, and cardiovascular disease. Mol Nutr Food Res 2005;49(6):594-600.
DOI: 10.1002/mnfr.200400112
Saji S, Asha S, Svenia PJ, Ratheesh M, Sheethal S, Sandya S, et al. Curcumin-galactomannoside complex inhibits pathogenesis in Ox-LDL-challenged human peripheral blood mononuclear cells. Inflammopharmacology 2018;26(5):1273-82.
DOI: 10.1007/s10787-018-0474-0
Wisniewski PJ, Dowden RA, Campbell SC. Role of Dietary Lipids in Modulating Inflammation through the Gut Microbiota. Nutrients 2019;11(1):117.
DOI: 10.3390/nu11010117
Alqurashi RM, Alarifi SN, Walton GE, Costabile AF, Rowland IR, Commane DM. In vitro approaches to assess the effects of acai (Euterpe oleracea) digestion on polyphenol availability and the subsequent impact on the faecal microbiota. Food Chem 2017;234:190-98.
DOI: 10.1016/j.foodchem.2017.04.164
Prasad KN, Bondy SC. Dietary Fibers and Their Fermented Short-Chain Fatty Acids in Prevention of Human Diseases. Mech Ageing Dev 2018;S0047-6374(18)30013-7.
DOI: 10.1016/j.mad.2018.10.003
Ribeiro VP, Arruda C, Abd El-Salam M, Bastos JK. Brazilian medicinal plants with corroborated anti-inflammatory activities: a review. Pharm Biol 2018;56(1):253-68.
DOI: 10.1080/13880209.2018.1454480
Kim H, Simbo SY, Fang C, McAlister L, Roque A, Banerjee N, et al. Açaí (Euterpe oleracea Mart.) beverage consumption improves biomarkers for inflammation but not glucose- or lipid-metabolism in individuals with metabolic syndrome in a randomized, double-blinded, placebo-controlled clinical trial. Food & Function 2018;9(6):3097-103.
DOI: 10.1039/C8FO00595H
Del Pozo-Insfran D, Brenes CH, Talcott ST. Phytochemical composition and pigment stability of Acai (Euterpe oleracea Mart.). J Agric Food Chem 200424;52(6):1539-45.
DOI: 10.1021/jf035189n
Chin YW, Chai HB, Keller WJ, Kinghorn AD. Lignans and other constituents of the fruits of Euterpe oleracea (Acai) with antioxidant and cytoprotective activities. J Agric Food Chem 2008;56(17):7759-64.
DOI: 10.1021/jf801792n
Kang J, Xie C, Li Z, Nagarajan S, Schauss AG, Wu T, et al. Flavonoids from acai (Euterpe oleracea Mart.) pulp and their antioxidant and anti-inflammatory activities. Food Chem 2011;128(1):152-7.
DOI: 10.1016/j.foodchem.2011.03.011
Xie C, Kang J, Li Z, Schauss AG, Badger TM, Nagarajan S, et al. The acai flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-alpha and IL-6 production through inhibiting NF-kappaB activation and MAPK pathway. J Nutr Biochem 2012;23(9):1184-91.
DOI: 10.1016/j.jnutbio.2011.06.013

Artículos Relacionados:

Trabajo Original: Açai improves non-alcoholic fatty liver disease (nafld) induced by fructose

Mayara Medeiros De Freitas Carvalho , Larissa Lélis Teixeira Reis , Juliana Márcia Macedo Lopes , Nara Nunes Lage , Joyce Ferreira Da Costa Guerra , Helena Porto Zago , Larissa De Freitas Bonomo , Renata Rebeca Pereira , Wanderson Geraldo De Lima , Marcelo Eustáquio Silva , Maria Lucia Pedrosa

Publicado: 2017-05-17 /

Trabajo Original: Anthropometric measure and adipokine levels of a young undergraduate population with a usual diet

Pedro Reyes-Castillo , Raquel González-Vázquez , Angélica Gutiérrez-Nava , Felipe Mendoza- Pérez , María del Carmen Navarro González , Alfonso Salgado-Sguayo , Edgard Torres-Maravilla , Lino Mayorga Reyes

Publicado: 2018-03-09 /

Trabajo Original: ADIPQ gene polymorphism rs266729 (-11377 C>G) and metabolic syndrome risk in a Mexican population of western Mexico

Mayra Judith Garcia-Robles , Jaqueline Camarillo Alba , Manuel de Jesus Valenzuela Gurrola , Jesús Adrian López , Saul Ramírez-De los Santos

Publicado: 2020-06-07 /

Trabajo Original: Influence of G1359A polimorphysm of the cannabinoid receptor gene (CNR1) on insulin resistance and adipokines in patients with non alcoholic fatty liver disease

Publicado: 2021-10-05 /

Revisión: Adhesion molecules and chemokines: relation to anthropometric, body composition, biochemical and dietary variables

Publicado: 2021-11-04 /

Trabajo Original: The consumption of acai pulp changes the concentrations of plasminogen activator inhibitor-1 and epidermal growth factor (EGF) in apparently healthy women

Publicado: 2022-01-12 /

Trabajo Original: Behavior of adipokines after a year follow-up in the Obesity Outpatient Clinic for Children and Adolescents

Publicado: 2022-01-19 /

Trabajo Original: La merienda con elevada proteína de lactosuero mejora el nivel de saciedad y disminuye el apetito en mujeres sanas

Publicado: 2022-01-19 /

Artículos más populares

Revisión: Ayuno intermitente: efectos en diversos escenarios clínicos

Introducción: los esquemas de ayuno intermitente (...

Publicado: 2023-05-24

Trabajo Original: Body mass index and risk of inflammatory breast disease: a Mendelian randomization study

Introduction: in previous studies, obesity was ide...

Publicado: 2023-04-22

Una cookie o galleta informática es un pequeño archivo de información que se guarda en su navegador cada vez que visita nuestra página web. La utilidad de las cookies es guardar el historial de su actividad en nuestra página web, de manera que, cuando la visite nuevamente, ésta pueda identificarle y configurar el contenido de la misma en base a sus hábitos de navegación, identidad y preferencias. Las cookies pueden ser aceptadas, rechazadas, bloqueadas y borradas, según desee. Ello podrá hacerlo mediante las opciones disponibles en la presente ventana o a través de la configuración de su navegador, según el caso. En caso de que rechace las cookies no podremos asegurarle el correcto funcionamiento de las distintas funcionalidades de nuestra página web. Más información en el apartado “POLÍTICA DE COOKIES” de nuestra página web.