Nutrición Hospitalaria 04024 / http://dx.doi.org/10.20960/nh.04024

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Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study

Mabelle Alves Ferreira de Lima, Karla Simone Costa de Souza, César Endrigo Silva de Andrade, Marcela Abbott Galvão Ururahy, Paulo José de Medeiros, Maurício Galvão Pereira, José Bruno de Almeida, Karine Cavalcanti Maurício Sena Evangelista, Adriana Augusto de Rezende

Prepublicado: 2023-01-26

Publicado: 2023-04-10

VOLUMEN 40, NÚM. 2, marzo-abril (2023), PAG. 412-418

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Introduction: Low 25-hydroxyvitamin D [25(OH)D] levels occur after kidney transplantation (KTx), and can be associated with increase the risk of graft loss. This longitudinal study aimed to evaluate the vitamin D status and association with biomarkers of the renal graft function after KTx. Methods: this longitudinal study included 42 patients evaluated at baseline, 3 and 6 months after KTx. Biodemographic, clinical, and biochemical parameters such as 25(OH)D and parathyroid hormone (PTH), and biomarkers of renal graft function, such as creatinine, estimated glomerular filtration rate (eGFR), and albumin/creatinine ratio (ACR), were assessed. Sun exposure was also evaluated. Patients were categorized according to their 25(OH)D levels. Results: at baseline, 25(OH)D levels < 30 ng/mL were found in 43 % patients, and 38 % of these patients failed to improve their 25(OH)D levels by 6 months after KTx. Low 25(OH)D levels occurred regardless of sun exposure. Further, 44 % patients developed albuminuria at 6 months. An increased ACR was observed in patients with 25(OH)D levels < 30 ng/mL (p = 0.002) compared to that in patients with 25(OH)D > 30 ng/mL. Additionally, 25(OH)D levels were negatively correlated with ACR at 6 months post-KTx (r = -0.444; p = 0.003). Twelve (28.6 %) patients with 25(OH)D levels < 30 ng/mL showed no eGFR recovery until 6 months after KTx. Conclusion: low vitamin D levels and increased albuminuria were observed at 6 months after KTx, even in a region with high sun exposure. The association between vitamin D status and biomarkers of renal graft function after KTx should be explored in further studies.

Palabras Clave: Kidney transplantation. 25-Hydroxyvitamin D. Hypovitaminosis D. Albuminuria. Albumin/creatinine ratio.

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