Trabajo Original
Common variants in genes related to lipid and energy metabolism are associated with weight loss after an intervention in overweight/obese adolescents
Número de descargas:
10632
Número de visitas:
2918
Citas:
0
Compártelo:
Background: Some SNPs related to lipid and energy metabolism may be implicated not only in the development of obesity and associated comorbidities, but also in the weight loss response after a nutritional intervention. Objective: In this context, the present study analyzed four SNPs located within four genes known to be associated with obesity and other obesity-related complications, and their putative role in a weight-loss intervention in overweight/obese adolescents. Methods: The study population consisted of 199 overweight/obese adolescents (13-16 yr old) undergoing 10 weeks of a weight loss multidisciplinary intervention: the EVASYON programme (www.estudioevasyon.org). Adolescents were genotyped for 4 SNPs, and anthropometric measurements and biochemical markers were analyzed at the beginning and after the intervention. Results: Interestingly, APOA5(rs662799) was associated with the baseline anthropometric and biochemical outcomes, whereas FTO (rs9939609) seemed to be related with the change of these values after the 10-week intervention. The other two SNPs, located in the CETP (rs1800777) and the APOA1 (rs670) genes, showed important relationships with adiposity markers. Specifically, a combined model including both SNPs turned up to explain up to 24% of BMI-SDS change after 10 weeks of the multidisciplinary intervention, which may contribute to under - stand the weight loss response. Conclusion: Common variants in genes related to lipid and energy metabolism may influence not only biochemical outcomes but also weight loss response after a multidisciplinary intervention carried out in obese/overweight adolescents..
Palabras Clave: APOA1. CETP. EVASYON. FTO. APOA5.
Artículos Relacionados:
Trabajo Original: Association of the rs9939609 gene variant in fto with insulin resistance, cardiovascular risk factor and serum adipokine levels in obese patients
Daniel de Luis Román , Rocio Aller , Olatz Izaola , David Primo , E. Romero
Trabajo Original: Relación de la variante rs1800777 del gen cetp (proteína transportadora de ésteres de colesterol) con la masa grasa y hdl colesterol, en sujetos obesos con diabetes mellitus tipo 2
Daniel Antonio De Luis , Olatz Izaola , David Primo , Susana García Calvo , Emilia Gómez Hoyos , Juan José López Gómez , Ana Ortolá Buigues , Cristina Serrano , Esther Delgado García , Beatriz Torres Torres
Trabajo Original: Asociación del polimorfismo rs3751812 del gen FTO con marcadores de adiposidad y metabólicos en población chilena. Resultados del estudio GENADIO
Lorena Mardones , Fanny Petermann-Rocha , María Adela Martínez-Sanguinetti , Ana María Leiva , Claudia Andrea Troncoso Pantoja , Miquel Martorell , Natalia Ulloa , Nicole Francisca Lasserre Laso , Francisco Pérez-Bravo , Carlos Celis-Morales , Marcelo Villagrán
Trabajo Original: INSIG2 gene polymorphism is associated with higher blood pressure and triglyceride levels in Brazilian obese subjects
Carolina F. Nicoletti , Raquel G. Azevedo , Marcela A.S. Pinhel , Heitor B.P. Delfino , Carla B. Nonino
Trabajo Original: Influencia de la variante rs670 del gen APOA1 en la respuesta HDL sérica a una dieta hipocalórica enriquecida con grasas poliinsaturadas frente a una enriquecida con grasas monoinsaturadas
Daniel de Luis Román , Olatz Izaola Jáuregui , David Primo Martín , Rocio Aller
Trabajo Original: Design of the nutritional therapy for overweight and obese Spanish adolescents conducted by registered dieticians; the EVASYON study
Trabajo Original: Relación del polimorfismo rs9939609 del gen FTO con factores de riesgo cardiovascular y niveles de adipocitoquinas en pacientes con obesidad mórbida
Trabajo Original: Role of ApoA1 on High-Density Lipoprotein: an intervention with plant sterols in patients with hypercholesterolemia
Trabajo Original: Independent and combined influence of the FTO rs9939609 and MC4R rs17782313 polymorphisms on hypocaloric diet induced changes in body mass and composition and energy metabolism in non-morbid obese premenopausal women
Trabajo Original: Role of rs9939609 FTO gene variant in weight loss, insulin resistance and metabolic parameters after a high monounsaturated vs a high polyunsaturated fat hypocaloric diets
Trabajo Original: Body composition changes during a multidisciplinary treatment programme in overweight adolescents: EVASYON Study
Artículos más populares
Revisión: La importancia de la alimentación en la prevención de la endometriosis: revisión sistemática
Antecedentes y objetivo: la endometriosis es un tr...
-
Licencia creative commons: Open Access bajo la licencia Creative Commons 4.0 CC BY-NC-SA
https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
