Nutrición Hospitalaria H1636
Resumen| PDF (ENGLISH)

Trabajo Original

Trans fatty acids modify nutritional parameters and triacylglycerol metabolism in rats: differential effects at recommended and high-fat levels


Logo Descargas   Número de descargas: 228      Logo Visitas   Número de visitas: 34

Compártelo:


Introduction: there is still little evidence on the metabolic trans fatty acids (TFA) effects at recommended fat levels. Objective: to investigate the differential TFA effects on some nutritional parameters, TFA retention, and triacylglycerol (TAG) regulation in rats fed recommended and high-fat diets. Methods: male Wistar rats were fed (30 days) diets containing recommended (7%,w/w) or high-fat (20%,w/w) levels, supplemented or not with TFA (C7, C20, TFA7 and TFA20). Results: TFA7 (vs.C7) rats showed an increased body weight associated with higher fat pads and liver and serum TAG. The hypertriacylglyceridaemia was related to a decreased muscle LPL activity, while the higher hepatic TAG content was associated with both an increased SREBP-1c gene expression and ACC activity, and a reduced CPT-Ia gene expression. The TFA20 diet did not potentiate the higher body weight, fat pads and TAG levels induced by the C20 diet. Although the hepatic TAG-secretion rate (TAG-SR) increased by TFA20 vs. C20, the same triacylglyceridaemia was associated with a compensatory increase of the adipose tissue LPL activity. The attenuated hepatic TAG accretion in TFA20 was related to an increase of TAG-SR and to a lower increase of SREBP-1c and SCD1 mRNA expressions, paralleled to a relative decrease of SCD1 index and ACC activity. Discussion and conclusion: TFA alters nutritional parameters and lipid metabolism in rats. However, different responses to the TFA on TAG levels and their regulation were observed between rats fed recommended and high-fat diets. These divergences might be related to different tissue TFA retentions and rumenic acid bioconversion.

Palabras Clave: Isomer retention. Triacylglycerol-secretion rate. Lipoprotein lipase. Lipid regulation. Lipid accretion.



Artículos Relacionados:

Trabajo Original: Effect of conjugated linoleic acid mixtures and different edible oils on body composition and lipid regulation in mice

Publicado: 2021-11-03 / http://dx.doi.org/

Artículos más populares

Revisión: Manejo nutricional del paciente hospitalizado críticamente enfermo con COVID-19. Una revisión narrativa

La pandemia actual por COVID-19 afecta principalme...

Publicado: 2020-05-25

Revisión: Evidence-based recommendations of the Andalusian Group for Nutrition Reflection and Investigation (GARIN) for the management of adult patients with short bowel syndrome

In order to develop evidence-based recommendations...

Publicado: 2021-05-18

Trabajo Original: Nutritional risk and clinical outcomes in critically ill adult patients with COVID-19

Introduction: the COVID-19 pandemic put the world'...

Publicado: 2021-06-23

Una cookie o galleta informática es un pequeño archivo de información que se guarda en su navegador cada vez que visita nuestra página web. La utilidad de las cookies es guardar el historial de su actividad en nuestra página web, de manera que, cuando la visite nuevamente, ésta pueda identificarle y configurar el contenido de la misma en base a sus hábitos de navegación, identidad y preferencias. Las cookies pueden ser aceptadas, rechazadas, bloqueadas y borradas, según desee. Ello podrá hacerlo mediante las opciones disponibles en la presente ventana o a través de la configuración de su navegador, según el caso. En caso de que rechace las cookies no podremos asegurarle el correcto funcionamiento de las distintas funcionalidades de nuestra página web. Más información en el apartado “POLÍTICA DE COOKIES” de nuestra página web.