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Exercise improved semen quality and reproductive hormone levels in sedentary obese adults

Miguel Ángel Rosety, Antonio Jesus Díaz, Jesús María Rosety, María Teresa Pery, Francisco Brenes-martín, Marco Bernardi, Natalia García-Vazquez, Manuel Rosety-rodríguez, Francisco Javier Ordoñez, Ignacio Rosety

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Introduction: From the previously published literature on the relationship between obesity and infertility, it is clear that male obesity negatively impacts semen quality. Accordingly, this study was conducted to determine whether regular exercise may improve semen quality in sedentary obese adults.Material and methods: Ninety obese adults were randomly allocated to the intervention (n = 45) or control group (n = 45). Participants in the intervention group performed a 16-week aerobic training program in a treadmill, three sessions per week, consisting of a warm-up (10-15 minutes), 35-50 minutes treadmill exercise (increasing five minutes per four weeks) at a work intensity of 50-65% of peak heart rate (increasing a 5% per four weeks) and cooling-down (5-10 minutes). Semen quality assessment included semen volume, sperm concentration and the percentages of progressive motility and normal morphology. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone and estradiol were determined by ELISA. Body composition and physical fitness were also assessed. Results: After the completion of the training program, sperm count, motility and normal morphology were significantly increased. A second key finding was that exercise improved reproductive hormone levels by increasing serum testosterone. Lastly, significant correlations were found between seminal outcomes and abdominal obesity.Conclusion: A short-term intervention program based on aerobic training improved semen quality in sedentary obese adults. This finding may be explained, at least in part, by an improvement of the reproductive hormone profile.

Palabras Clave: Obesity. Aerobic training. Semen. Testosterone.

Boulicault, Marion, Perret, Meg, Galka, Jonathan, Borsa, Alex, Gompers, Annika, Reiches, Meredith, Richardson, Sarah (2022) The future of sperm: a biovariability framework for understanding global sperm count trends. Human Fertility
Köhn, F.-M., Behre, H. M., Schuppe, H.-C. (2019) Andrologische Anamnese – welche Fragen sollten auch Gynäkologen stellen?. Gynäkologische Endokrinologie
Bernardi, Marco, Fedullo, Anna Lucia, Bernardi, Elisabetta, Munzi, Diego, Peluso, Ilaria, Myers, Jonathan, Lista, Florigio Romano, Sciarra, Tommaso (2020) Diet in neurogenic bowel management: A viewpoint on spinal cord injury. World Journal of Gastroenterology
Hwang, Kathleen, Guo, David (2019) Sports-related Male Infertility. European Urology Focus
Giulioni, Carlo, Maurizi, Valentina, Galosi, Andrea Benedetto (2023) The role of physical agents’ exposure in male infertility: A critical review. Archivio Italiano di Urologia e Andrologia
Rimmer, Michael P, Howie, Ruth A, Subramanian, Venkatesh, Anderson, Richard A, Bertolla, Ricardo Pimenta, Beebeejaun, Yusuf, Bortoletto, Pietro, Sunkara, Sesh K, Mitchell, Rod T, Pacey, Allan, van Wely, Madelon, Farquhar, Cindy M, Duffy, James M N, Niederberger, Craig (2022) Outcome reporting across randomized controlled trials evaluating potential treatments for male infertility: a systematic review. Human Reproduction Open
Chang, Bo, Song, Chenglin, Gao, Haining, Ma, Tie, Li, Tao, Ma, Qianhe, Yao, Tingting, Wang, Meng, Li, Jing, Yi, Xuejie, Tang, Donghui, Cao, Shicheng (2021) Leptin and inflammatory factors play a synergistic role in the regulation of reproduction in male mice through hypothalamic kisspeptin-mediated energy balance. Reproductive Biology and Endocrinology
Zan, Gaohui, Li, Longman, Cheng, Hong, Huang, Lulu, Huang, Sifang, Luo, Xiaoyu, Xiao, Lili, Liu, Chaoqun, Zhang, Haiying, Mo, Zengnan, Yang, Xiaobo (2021) Mediated relationships between multiple metals exposure and fasting blood glucose by reproductive hormones in Chinese men. Environmental Pollution
Hosick, Peter A., Matthews, Evan L., Leigh, Steven (2020) Cardiorespiratory fitness and the relationship between body fat and resting testosterone in men. Archives of Physiology and Biochemistry
Lavín-Pérez, Ana Myriam, Collado-Mateo, Daniel, Villafaina, Santos, Calle-Guisado, Violeta (2021) The Role of Exercise to Reduce the Impact of Diabetes in the Seminal Quality: A Systematic Review. Medicina
Nikbin, Sina, Derakhshideh, Armin, Hozouri Tarighe, Mahsa, Khojasteh, Zohreh, Kanozi, Foad, Mousavi, Niloufar, Afshar, Tayebeh, Karami, Maryam, Zolfaghari, Fatemeh Sadat, Azarbayjani, Mohammad Ali (2020) Synergic effects of aerobic exercise and eugenol supplement on germ cell development and testicular tissue structure in chlorpyrifos-treated animal model. Environmental Science and Pollution Research
Zouhal, Hassane, Jayavel, Ayyappan, Parasuraman, Kamalanathan, Hayes, Lawrence D., Tourny, Claire, Rhibi, Fatma, Laher, Ismail, Abderrahman, Abderraouf Ben, Hackney, Anthony C. (2022) Effects of Exercise Training on Anabolic and Catabolic Hormones with Advanced Age: A Systematic Review. Sports Medicine
Park, Se Hwan, Kwak, Hyo Bum, Yoon, Jin Hwan (2019) Effects of obesity and exercise on sperm quality and function. Korean Journal of Sport Science
Sansone, Andrea, Sansone, Massimiliano, Vaamonde, Diana, Sgrò, Paolo, Salzano, Ciro, Romanelli, Francesco, Lenzi, Andrea, Di Luigi, Luigi (2018) Sport, doping and male fertility. Reproductive Biology and Endocrinology
Saez, Fabrice, Drevet, Joël R. (2019) Dietary Cholesterol and Lipid Overload: Impact on Male Fertility. Oxidative Medicine and Cellular Longevity
Li, Yinlam, Zhang, Li, Zheng, Xiaoguo, Qian, Jianing, Li, Yanquan, Xie, Chong, Zhang, Xuelian, Zhou, Yuchuan, Huang, Hefeng (2021) Dietary restriction and/or exercise training impairs spermatogenesis in normal rats. Applied Physiology, Nutrition, and Metabolism
Nematollahi, Arezou, Kazeminasab, Fatemeh, Tavalaee, Marziyeh, Marandi, Sayed M., Ghaedi, Kamran, Nazem, Mohammad N., Nasr‐Esfahani, Mohammad Hossein (2019) Effect of aerobic exercise, low‐fat and high‐fat diet on the testis tissue and sperm parameters in obese and nonobese mice model. Andrologia
Riachy, Ruba, McKinney, Kevin, Tuvdendorj, Demidmaa R. (2020) Various Factors May Modulate the Effect of Exercise on Testosterone Levels in Men. Journal of Functional Morphology and Kinesiology
Lin, Tingting, Zhang, Shuyu, Zhou, Yuchuan, Wu, Ligang, Liu, Xinmei, Huang, Hefeng (2022) Small RNA perspective of physical exercise-related improvement of male reproductive dysfunction due to obesity. Frontiers in Endocrinology
Andersen, Emil, Juhl, Christian R, Kjøller, Emma T, Lundgren, Julie R, Janus, Charlotte, Dehestani, Yasmin, Saupstad, Marte, Ingerslev, Lars R, Duun, Olivia M, Jensen, Simon B K, Holst, Jens J, Stallknecht, Bente M, Madsbad, Sten, Torekov, Signe S, Barrès, Romain (2022) Sperm count is increased by diet-induced weight loss and maintained by exercise or GLP-1 analogue treatment: a randomized controlled trial. Human Reproduction
Osadchuk, L. V., Osadchuk, A. V. (2023) Individual Lifestyle and Male Fertility. Human Physiology
Chen, Dequan, Cao, Shicheng, Chang, Bo, Ma, Tie, Gao, Haining, Tong, Yao, Li, Tao, Han, Junchao, Yi, Xuejie (2019) Increasing hypothalamic nucleobindin 2 levels and decreasing hypothalamic inflammation in obese male mice via diet and exercise alleviate obesity-associated hypogonadism. Neuropeptides
(2019) Exercise, training, and the hypothalamic–pituitary–gonadal axis in men. Current Opinion in Endocrine and Metabolic Research
Lunetti, Paola, Capobianco, Loredana, Zara, Vincenzo, Ferramosca, Alessandra (2021) Physical Activity and Male Reproductive Function: A New Role for Gamete Mitochondria. Exercise and Sport Sciences Reviews
Schuppe, Hans-Christian, Köhn, Frank-Michael (2022) Umweltfaktoren, Lebensstil und männliche Fertilität. Die Urologie
Bernardi, Marco, Peluso, Ilaria (2020) Interactions between oxidative stress and cardiorespiratory fitness: Old and new biomarkers. Current Opinion in Toxicology
Aghamiri, Seyed Mahdi, Eslami Farsani, Mohsen, Seyedebrahimi, Reihaneh, Sarikhani, Mohammad Javad, Ababzadeh, Shima (2023) Synergic Effects of Rosemary Extract and Aerobic Exercise on Sperm Parameters and Testicular Tissue in an Aged Rat Model. Gene, Cell and Tissue
Köhn, Frank-Michael, Schuppe, Hans-Christian (2017) Kein Nachwuchs in Sicht: Sind Alkohol und Zigaretten schuld?. MMW - Fortschritte der Medizin
Köhn, Frank-Michael, Schuppe, Hans-Christian (2021) Der Einfluss von Umweltfaktoren und Lebensstil auf die männliche Fertilität. Der Gynäkologe
Hajshafiha M, Ghareaghaji R, Salemi S, Sadegh-Asadi N, Sadeghi-Bazargani H. Association of body mass index with some fertility markers among male partners of infertile couples. Int J Gen Med 2013;6:447-51.
Hammiche F, Laven JS, Twigt JM, Boellaard WP, Steegers EA, Steegers-Theunissen RP. Body mass index and central adiposity are associated with sperm quality in men of subfertile couples. Hum Reprod 2012;27:2365-72.
DOI: 10.1093/humrep/des177
Bener A, Al-Ansari AA, Zirie M, Al-Hamaq AO. Is male fertility associated with type 2 diabetes mellitus? Int Urol Nephrol 2009;41:777-84.
Sermondade N, Faure C, Fezeu L, et al: BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update 2013;19:221-31.
Al-Ali B, Gutschi T, Pummer K, et al: Body mass index has no impact on sperm quality but on reproductive hormones levels. Andrologia 2014;46:106-11.
Ivell R. Lifestyle impact and the biology of the human scrotum. Reprod Biol Endocrinol 2007;5:15.
DOI: 10.1186/1477-7827-5-15
Fariello RM, Pariz JR, Spaine DM, Cedenho AP, Bertolla RP, Fraietta R. Association between obesity and alteration of sperm DNA integrity and mitochondrial activity. BJU Int 2012;110:863-7.
DOI: 10.1111/j.1464-410X.2011.10813.x
Palmer NO, Bakos HW, Owens JA, Setchell BP, Lane M. Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function. Am J Physiol Endocrinol Metab 2012;302:768–80.
DOI: 10.1152/ajpendo.00401.2011
Vaamonde D, Da Silva-Grigoletto ME, García-Manso JM, García-Manso JM, Barrera N, Vaamonde-Lemos R. Physically active men show better semen parameters and hormone values than sedentary men. Eur J Appl Physiol 2012;112:3267-73.
DOI: 10.1007/s00421-011-2304-6
Pelliccione F, Verratti V, D'Angeli A, et al: Physical exercise at high altitude is associated with a testicular dysfunction leading to reduced sperm concentration but healthy sperm quality. Fertil Steril 2011;96:28-33.
Safarinejad MR, Azma K, Kolahi AA. The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus-pituitary-testis axis, and semen quality: a randomized controlled study. J Endocrinol 2009;200:259-71.
DOI: 10.1677/JOE-08-0477
Mínguez-Alarcón L, Chavarro JE, Mendiola J, Gaskins AJ, Torres-Cantero AM. Physical activity is not related to semen quality in young healthy men. Fertil Steril 2014;102:1103-9.
DOI: 10.1016/j.fertnstert.2014.06.032
Fritz M, Speroff L. Clinical Gynecologic Endocrinology and Infertility. 8th ed. Philadelphia: Lippincott Williams & Wilkins; 2010.
Makler A, Zaidise I, Brandes JM. Elimination of errors induced during a routine human sperm motility analysis. Arch Androl 1979;3:201–210.
DOI: 10.3109/01485017908988406
WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. 4th edition. Cambridge, UK: Cambridge University Press; 1999.
Gaskins AJ, Mendiola J, Afeiche M, Jørgensen N, Swan SH, Chavarro JE. Physical activity and television watching in relation to semen quality in young men. Br J Sports Med 2015; 49:265-70.
DOI: 10.1136/bjsports-2012-091644
Wise LA, Cramer DW, Hornstein MD, Ashby RK, Missmer SA. Physical activity and semen quality among men attending an infertility clinic. Fertil Steril 2011;95:1025-30.
DOI: 10.1016/j.fertnstert.2010.11.006
Iborra RT, Ribeiro IC, Neves MQ, et al: Aerobic exercise training improves the role of high-density lipoprotein antioxidant and reduces plasma lipid peroxidation in type 2 diabetes mellitus. Scand J Med Sci Sports 2008;18:742-50.
Tartibian B, Maleki BH. Correlation between seminal oxidative stress biomarkers and antioxidants with sperm DNA damage in elite athletes and recreationally active men. Clin J Sport Med 2012;22:132-9.
DOI: 10.1097/JSM.0b013e31823f310a
Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril 2010;93:2222-31.
DOI: 10.1016/j.fertnstert.2009.01.100
Håkonsen LB, Thulstrup AM, Aggerholm AS, et al: Does weight loss improve semen quality and reproductive hormones? Results from a cohort of severely obese men. Reprod Health 2011;8:24.
Khoo J, Tian HH, Tan B, et al: Comparing effects of low- and high-volume moderate-intensity exercise on sexual function and testosterone in obese men. J Sex Med 2013;10:1823-32.
Fejes I, Koloszár S, Szöllosi J, Závaczki Z, Pál A. Is semen quality affected by male body fat distribution? Andrologia 2005;37:155-9.
Eskandar M, Al-Asmari M, Babu Chaduvula S, et al: Impact of male obesity on semen quality and serum sex hormones. Adv Urol 2012;2012:407601.
MacDonald AA, Herbison GP, Showell M, Farquhar CM. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update 2009;16:293–311.
DOI: 10.1093/humupd/dmp047
Heller CG, Clermont Y. Spermatogenesis in man: an estimate of its duration. Science 1963;140:184–186.
DOI: 10.1126/science.140.3563.184

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