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This paper summarizes the recent findings from studies investigating the potential environmental modulation of the genetic variation of apolipoprotein genes on metabolic traits. We reviewed nutrigenetic studies evaluating variations on apolipoproteins-related genes and its associated response to nutrients (mostly dietary fatty acids) or any other dietary or environmental component. Most revised research studied single nucleotide polymorphism (SNP) and specific nutrients through small intervention studies, and only few interactions have been replicated in large and independent populations (as in the case of -265T > C SNP in APOA2 gene). Although current knowledge shows that variations on apolipoprotein genes may contribute to the different response on metabolic traits due to dietary interventions, evidence is still scarce and results are inconsistent. Success in this area will require going beyond the limitations of current experimental designs and explore the hypotheses within large populations. Some of these limitations are being covered by the rapidly advance in high-throughput technologies and large scale-genome wide association studies.
Palabras Clave: Apolipoprotein. Gene-diet interaction. Environment. Nutrigenetics. Dietary interventions.
José Manuel Moreno Villares , Miguel Sáenz de Pipaón , Ángel Carrasco Sanz , Juan José Díaz Martín , Susana Redecillas Ferreiro , Ana Moráis López , Félix Sánchez Valverde , Víctor Manuel Navas-López , Miguel Ángel San José González , Rosaura Leis Trabazo , Mercedes Gil-campos , Luis Carlos Blesa Baviera , Cristina Campoy Folgoso
Juan Carlos Sánchez-García , María José Aguilar-Cordero , María José Menor-Rodríguez , Angelica María Paucar Sánchez , Raquel Rodríguez-Blanque
Valeria Navarro Fernández , Fernando Vio del Río
Martín Gildardo García Alvarado , Luis Humberto Ruiz García , Julio Alfonso Piña López
Carolina Franch Maggiolo , Lorena Rodríguez Osiac , Paula Hernandez Hirsch , Isabel Pemjean Contreras
Claudia Andrea Troncoso Pantoja , Mari Alarcón Riveros , Vanessa Rodríguez-Pindave
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