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Background: The aim was to evaluate the effects of glutamine on tumor regression and histological damage in patients with rectal patients following chemoradiotherapy previous to surgery. Material and methods: Ten patients with rectal cancer surgically removed after chemoradiotherapy were included, a subgroup of a randomized trial that compared glutamine and placebo in the prevention of acute radiation enteritis. Samples of neoplasm and healthy tissue were evaluated by an expert pathologist searching for signs of tumor regression, muciphages, and signs of radiation-induced damage. Results: There were no differences in the grade of tumor regression with either glutamine or placebo. All patients who received glutamine presented muciphages, compared with 28.6% of the placebo group (p = 0.038). Histological damage was similar in patients receiving glutamine or placebo, and between those with radiation enteritis or without toxicity. Conclusion: Glutamine did not exert a protective effect over chemoradiotherapy in rectal cancer or healthy rectal tissue.
Palabras Clave: Glutamine. Chemoradiotherapy. Enteritis. Muciphages.
Elizângela Gonçalves Schemitt , Josieli Raskopf Colares , Renata Minuzzo Hartmann , María Isabel Morgan-martins , Cláudio Augusto Marroni , M. Jesús Tuñón , Norma Possa Marroni
Yazmin Lizeth Beltrán Chaidez , Diana Yolanda Reyes Barretero , Miriam Verónica Flores Merino , Emigdio Jaimes Alpizar , Valerie Yselle de Anda Torres , M.ª Victoria Domínguez García
Blanca G. Beltrán Piña , Martha I. González Castro , Marta Irene Gonzalez Castro
Rodrigo Fernandes Weyll Pimentel , Sandra Lúcia Fernandes
Cristina Tejera Pérez , Cristina Guillín Amarelle , Nazareth Rodríguez Novo , Gloria Lugo Rodríguez , Beatriz Mantiñán Gil , Regina Palmeiro Carballeira , Francisco Pita Gutiérrez , Rosa Argüeso Armesto , Ana Cantón Blanco , Manuel Antonio Botana López , María Teresa Fernández López , Virginia Muñoz Leira , Santiago Rodeiro Marta , Miguel Ángel Martínez Olmos