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Background/Aims: to examine the relationship between the antioxidant potential and severity parameters of cirrhosis in humans. Methods: fifteen patients with hepatic cirrhosis (nine subjects – Child group B, and six subjects – Child group C) and nine control subjects were enrolled in the study. The main criteria taken into account to characterize the diagnosis of cirrhosis and its complications were the AST: ALT ratio, AST to platelet ratio index, Bonacini score, Meld score and Child classification. Those parameters were determined based on laboratory results and patient’s clinical records. Se, Zn, ascorbic acid (AA) levels and oxidative stress parameters were measured in blood samples of cirrhotic patients. Results: the analysis of plasma levels of Se and AA showed low concentrations in cirrhotic patients compared with control subjects (P < 0.05). Though, there was a positive correlation between plasma of Se and severity parameters of cirrhosis in patients of Child group B and C. In the activity of the antioxidant enzymes only catalase was lower in patients of Child group C compared with control group. Conclusion: we found low plasma levels of Se and AA among cirrhotic patients. However, is not clear why selenium levels tend to increase with the severity of liver cirrhosis.
Palabras Clave: Selenium. Ascorbic acid. Flow cytometry. Hepatic cirrhosis.
Caroline Pinho R. Andrade , Mileda L. T. Portugal , Ellén De Sousa Paz , Paula A. Freitas , Ana Filomena C. S. Daltro , Kaluce G. S. Almondes , Carla Soraya C. Maia , Ariclecio Cunha de Oliveira
Yuanfeng Gong , Fengying Dong , Yan Geng , Hongkai Zhuang , Zuyi Ma , Zixuan Zhou , Bowen Huang , Zhonghai Sun , Baohua Hou
María Reyes Pérez Fernández , Ismael Martínez Lede , José María Failde Garrido , Sabela Varela Rodríguez , Natalia Calvo Ayuso , Alberto José del Álamo Alonso
Juan Manuel Aldana Ledesma , Daniela Vázquez Rodríguez , Monserrat Lazcano Becerra , Edgar Santino García Jiménez , Diana Karen Tapia Calderón , Miguel Ángel Ibarra Estrada , Francisco Alejandro Félix Téllez , José Antonio Velarde Ruiz Velasco
Pilar Matía Martín , Víctor González-Sánchez , Rosa Burgos Peláez , José Manuel García Almeida , Samara Palma Milla , Alejandro Sanz Paris , Ana Zugasti Murillo , José Joaquín Alfaro-Martínez , Ana Artero-Fullana , Alfonso Calañas Continente , M.ª Jesús Chinchetru , Katherine García Malpartida , Ángela González-Díaz Faes , María Laínez López , Clara Serrano-Moreno , Antonio Jesús Martínez-Ortega , José Pablo Suárez Llanos , Juana Oliva Roldán
Mónica Zúñiga González , Ángel Roco-Videla