Nutrición Hospitalaria 02776 / http://dx.doi.org/10.20960/nh.02776

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Selenium concentration, dietary intake and risk of hepatocellular carcinoma – A systematic review with meta-analysis

Yuanfeng Gong, Fengying Dong, Yan Geng, Hongkai Zhuang, Zuyi Ma, Zixuan Zhou, Bowen Huang, Zhonghai Sun, Baohua Hou

Prepublicado: 2019-11-13

Publicado: 2019-12-18

VOLUMEN 36, NÚM. 6, noviembre-diciembre (2019), PAG. 1430-1437

Logo Descargas Número de descargas: 25329 Logo Visitas Número de visitas: 6652 Citas Citas: 2

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Aim: this study was performed to investigate the association between selenium concentrations, dietary intake, and the risk of hepatocellular carcinoma (HCC). Methods: we identified eligible studies in PubMed and EMBASE databases, in addition to the reference lists of original studies and review articles on this topic, up to 1 Feb 2019. A summary of standardized mean differences (SMD) with 95% confidence intervals (CI) was calculated using a random-effects model. Heterogeneity between studies was assessed using Cochran Q and I2 statistics. Results: finally, a meta-analysis showed that dietary intake of selenium and tissue selenium concentration were not associated with HCC risk (dietary SMD = -0.11, 95% CI: -0.26 to 0.03; tissue SMD = -0.12, 95% CI: -0.56 to 0.33). However, samples from toenail, whole blood, and serum all showed an inverse association with HCC risk (toenail SMD = -0.53, 95% CI: -0.72 to -0.35; whole blood SMD = -2.21, 95% CI: -2.67 to -1.76; tissue SMD = -1.26, 95% CI: -1.71 to -0.81). Dose-response data from few studies showed that an extra increase in serum selenium was dramatically related with a lower risk of HCC (adjusted p-trend < 0.05). This study showed that selenium concentration in toenail, whole blood and serum was inversely associated with HCC risk. Conclusion: increased concentration in serum selenium was related to a lower risk of HCC. However, these results based on dietary intake and tissue samples, which included few studies, did not reach statistical significance.

Palabras Clave: Selenium. Selenoprotein. Hepatocellular carcinoma. Morbidity. Meta-analysis.

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