Nutrición Hospitalaria 04558 /
Resumen| PDF (ENGLISH)


Effect of dietary antioxidants on the risk of prostate cancer. Systematic review and network meta-analysis

Siyu Liu, Junhui Chen, Yiwen Wang, Yangyang Xu

Prepublicado: 2023-05-03
Publicado: 2023-06-12

Logo Descargas   Número de descargas: 323      Logo Visitas   Número de visitas: 2284      Citas   Citas: 2


Objective: the purpose of this study was to assess the impact of 14 treatments including a total of 10 dietary antioxidants on the risk of prostate cancer. Material and methods: we searched PubMed, Embase, the Cochrane Library, and the Web of Science for only randomized controlled trials (RCTs) to investigate the effect of these 10 antioxidants on the risk of getting prostate cancer. Using the Cochrane Risk of Bias Assessment Tool, the methodological quality of the included studies was evaluated. Data extraction: studies were appraised by two investigators and data were extracted. Using a surface under cumulative ranking (SUCRA) probability, a Bayesian network meta-analysis was undertaken to evaluate the relative ranking of agents. Results: from the earliest accessible date through August 2022, RCTs were gathered. A total of 14 randomized controlled trials were included with a total sample size of 73,365 males. The results of the network meta-analysis showed that green tea catechins (GTCs) significantly reduced the risk of prostate cancer (SUCRA, 88.6 %) followed by vitamin D (SUCRA, 55.1 %), vitamin B6 (54.1 %), and folic acid was the lowest (22.0 %). Conclusion: based on the Ranking Plot of the Network, we can state that GTCs might have an impact on the prevention of prostate cancer compared to other dietary antioxidants, but we still need quality literature to further prove it.

Palabras Clave: Dietary antioxidants. Prostate cancer. Network meta-analysis. Green tea catechins. Folic acid.

Li, Shanyi, Cai, Tong, Cui, Shichen, Liu, Fangmin, Hu, Rong, Li, Wenji (2023) Prostate Cancer, Oxidative Stress, and Antioxidant Phytochemicals: A Brief Review. Current Pharmacology Reports
Powers-James, Catherine, Morse, Meroë, Narayanan, Santhosshi, Ramondetta, Lois, Lopez, Gabriel, Wagner, Richard, Cohen, Lorenzo (2024) Integrative Oncology Approaches to Reduce Recurrence of Disease and Improve Survival. Current Oncology Reports
[1] Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021. 71(3): 209-249.
DOI: 10.3322/caac.21660
[2] Gann PH, Ma J, Giovannucci E, et al. Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res. 1999. 59(6): 1225-30.
[3] Chen L, Stacewicz-Sapuntzakis M, Duncan C, et al. Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. J Natl Cancer Inst. 2001. 93(24): 1872-9.
DOI: 10.1093/jnci/93.24.1872
[4] Clark LC, Dalkin B, Krongrad A, et al. Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Br J Urol. 1998. 81(5): 730-4.
DOI: 10.1046/j.1464-410x.1998.00630.x
[5] Clark LC, Combs GF Jr, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA. 1996. 276(24): 1957-63.
DOI: 10.1001/jama.276.24.1957
[6] Heinonen OP, Albanes D, Virtamo J, et al. Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. J Natl Cancer Inst. 1998. 90(6): 440-6.
DOI: 10.1093/jnci/90.6.440
[7] The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994. 330(15): 1029-35.
DOI: 10.1056/NEJM199404143301501
[8] Clark LC, Combs GF, Turnbull BW, et al. Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin: A Randomized Controlled Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 276.
DOI: 10.1001/jama.1996.03540240035027
[9] A. J, Duffield-Lillico, B. L, et al. Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. BJU INTERNATIONAL. 2003. 91(7): 608-612.
DOI: 10.1046/j.1464-410X.2003.04167.x
[10] Heinonen, Olli, P., et al. Prostate cancer and supplementation with ...-tocopherol and ...-Carotene: Incidence and mortality. Ji Journal of the National Cancer Institute. 1998.
DOI: 10.1093/jnci/90.6.440
[11] Fleshner N, Fair WR, Huryk R, Heston WD. Vitamin E inhibits the high-fat diet-promoted growth of established human prostate LNCaP tumors in nude mice. J Urol. 1999. 161(5): 1651-4.
DOI: 10.1016/S0022-5347(05)68998-7
[12] Ip C, Thompson HJ, Zhu Z, Ganther HE. In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention. Cancer Res. 2000. 60(11): 2882-6.
[13] Jiang C, Wang Z, Ganther H, Lu J. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells. Cancer Res. 2001. 61(7): 3062-70.
[14] Menter DG, Sabichi AL, Lippman SM. Selenium effects on prostate cell growth. Cancer Epidemiol Biomarkers Prev. 2000. 9(11): 1171-82.
[15] Redman C, Scott JA, Baines AT, et al. Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines. Cancer Lett. 1998. 125(1-2): 103-10.
DOI: 10.1016/S0304-3835(97)00497-7
[16] Taylor PR, Albanes D. Selenium, vitamin E, and prostate cancer--ready for prime time. J Natl Cancer Inst. 1998. 90(16): 1184-5.
DOI: 10.1093/jnci/90.16.1184
[17] Yoshizawa K, Willett WC, Morris SJ, et al. Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. J Natl Cancer Inst. 1998. 90(16): 1219-24.
DOI: 10.1093/jnci/90.16.1219
[18] Zhong W, Oberley TD. Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line. Cancer Res. 2001. 61(19): 7071-8.
[19] Rouse B, Chaimani A, Li T. Network meta-analysis: an introduction for clinicians. Intern Emerg Med. 2017. 12(1): 103-111.
DOI: 10.1007/s11739-016-1583-7
[20] Hutton B, Salanti G, Caldwell DM, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. 2015. 162(11): 777-84.
DOI: 10.7326/M14-2385
[21] Hoaglin DC, Hawkins N, Jansen JP, et al. Conducting indirect-treatment-comparison and network-meta-analysis studies: report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: part 2. Value Health. 2011. 14(4): 429-37.
DOI: 10.1016/j.jval.2011.01.011
[22] Higgins JP, Altman DG, Gøtzsche PC, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011. 343: d5928.
DOI: 10.1136/bmj.d5928
[23] Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015. 4(1): 1.
DOI: 10.1186/2046-4053-4-1
[24] Vats D, Flegal JM, Jones GL. Multivariate Output Analysis for Markov Chain Monte Carlo.
[25] Salanti G, Ades AE, Ioannidis JP. Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol. 2011. 64(2): 163-71.
DOI: 10.1016/j.jclinepi.2010.03.016
[26] Chaimani A, Higgins JP, Mavridis D, Spyridonos P, Salanti G. Graphical tools for network meta-analysis in STATA. PLoS One. 2013. 8(10): e76654.
DOI: 10.1371/journal.pone.0076654
[27] Marotta N, Demeco A, Moggio L, et al. Comparative effectiveness of breathing exercises in patients with chronic obstructive pulmonary disease. Complement Ther Clin Pract. 2020. 41: 101260.
DOI: 10.1016/j.ctcp.2020.101260
[28] Khera R, Murad MH, Chandar AK, et al. Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events: A Systematic Review and Meta-analysis. JAMA. 2016. 315(22): 2424-34.
DOI: 10.1001/jama.2016.7602
[29] Marshall JR, Tangen CM, Sakr WA, et al. Phase III trial of selenium to prevent prostate cancer in men with high-grade prostatic intraepithelial neoplasia: SWOG S9917. Cancer Prev Res (Phila). 2011. 4(11): 1761-9.
DOI: 10.1158/1940-6207.CAPR-10-0343
[30] Hennekens CH, Buring JE, Manson JE, et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med. 1996. 334(18): 1145-9.
DOI: 10.1056/NEJM199605023341801
[31] Manson JE, Cook NR, Lee IM, et al. Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. N Engl J Med. 2019. 380(1): 33-44.
DOI: 10.1056/NEJMoa1809944
[32] Figueiredo JC, Grau MV, Haile RW, et al. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst. 2009. 101(6): 432-5.
DOI: 10.1093/jnci/djp019
[33] Duffield-Lillico AJ, Dalkin BL, Reid ME, et al. Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. BJU Int. 2003. 91(7): 608-12.
DOI: 10.1046/j.1464-410X.2003.04167.x
[34] Kumar NB, Pow-Sang J, Egan KM, et al. Randomized, Placebo-Controlled Trial of Green Tea Catechins for Prostate Cancer Prevention. Cancer Prev Res (Phila). 2015. 8(10): 879-87.
DOI: 10.1158/1940-6207.CAPR-14-0324
[35] Gontero P, Marra G, Soria F, et al. A randomized double-blind placebo controlled phase I-II study on clinical and molecular effects of dietary supplements in men with precancerous prostatic lesions. Chemoprevention or "chemopromotion". Prostate. 2015. 75(11): 1177-86.
DOI: 10.1002/pros.22999
[36] Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res. 2006. 66(2): 1234-40.
DOI: 10.1158/0008-5472.CAN-05-1145
[37] Ebbing M, Bønaa KH, Nygård O, et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA. 2009. 302(19): 2119-26.
DOI: 10.1001/jama.2009.1622
[38] Fleshner NE, Kapusta L, Donnelly B, et al. Progression from high-grade prostatic intraepithelial neoplasia to cancer: a randomized trial of combination vitamin-E, soy, and selenium. J Clin Oncol. 2011. 29(17): 2386-90.
DOI: 10.1200/JCO.2010.32.0994
[39] Lippman SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2009. 301(1): 39-51.
DOI: 10.1001/jama.2009.627
[40] Lonn E, Bosch J, Yusuf S, et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA. 2005. 293(11): 1338-47.
DOI: 10.1001/jama.293.11.1338
[41] Algotar AM, Stratton MS, Ahmann FR, et al. Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer. Prostate. 2013. 73(3): 328-35.
DOI: 10.1002/pros.22573
[42] Wallace BC, Schmid CH, Lau J, Trikalinos TA. Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data. BMC Med Res Methodol. 2009. 9: 80.
DOI: 10.1186/1471-2288-9-80
[43] Caporali A, Davalli P, Astancolle S, et al. The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression. Carcinogenesis. 2004. 25(11): 2217-24.
DOI: 10.1093/carcin/bgh235
[44] Ahmad N, Feyes DK, Nieminen AL, Agarwal R, Mukhtar H. Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J Natl Cancer Inst. 1997. 89(24): 1881-6.
DOI: 10.1093/jnci/89.24.1881
[45] Albrecht DS, Clubbs EA, Ferruzzi M, Bomser JA. Epigallocatechin-3-gallate (EGCG) inhibits PC-3 prostate cancer cell proliferation via MEK-independent ERK1/2 activation. Chem Biol Interact. 2008. 171(1): 89-95.
DOI: 10.1016/j.cbi.2007.09.001
[46] Hultdin J, Van Guelpen B, Bergh A, Hallmans G, Stattin P. Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study. Int J Cancer. 2005. 113(5): 819-24.
DOI: 10.1002/ijc.20646
[47] Vlajinac HD, Marinković JM, Ilić MD, Kocev NI. Diet and prostate cancer: a case-control study. Eur J Cancer. 1997. 33(1): 101-7.
DOI: 10.1016/S0959-8049(96)00373-5
[48] Lawson KA, Wright ME, Subar A, et al. Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. J Natl Cancer Inst. 2007. 99(10): 754-64.
DOI: 10.1093/jnci/djk177
[49] Pelucchi C, Galeone C, Talamini R, et al. Dietary folate and risk of prostate cancer in Italy. Cancer Epidemiol Biomarkers Prev. 2005. 14(4): 944-8.
DOI: 10.1158/1055-9965.EPI-04-0787
[50] Rossi E, Hung J, Beilby JP, Knuiman MW, Divitini ML, Bartholomew H. Folate levels and cancer morbidity and mortality: prospective cohort study from Busselton, Western Australia. Ann Epidemiol. 2006. 16(3): 206-12.
DOI: 10.1016/j.annepidem.2005.03.010
[51] Shannon J, Phoutrides E, Palma A, et al. Folate intake and prostate cancer risk: a case-control study. Nutr Cancer. 2009. 61(5): 617-28.
DOI: 10.1080/01635580902846593
[52] Beilby J, Ambrosini GL, Rossi E, de Klerk NH, Musk AW. Serum levels of folate, lycopene, β-carotene, retinol and vitamin E and prostate cancer risk. Eur J Clin Nutr. 2010. 64(10): 1235-8.
DOI: 10.1038/ejcn.2010.124
[53] Johansson M, Appleby PN, Allen NE, et al. Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition study. Cancer Epidemiol Biomarkers Prev. 2008. 17(2): 279-85.
DOI: 10.1158/1055-9965.EPI-07-0657
[54] Kristal AR, Arnold KB, Neuhouser ML, et al. Diet, supplement use, and prostate cancer risk: results from the prostate cancer prevention trial. Am J Epidemiol. 2010. 172(5): 566-77.
DOI: 10.1093/aje/kwq148
[55] Stevens VL, Rodriguez C, Pavluck AL, McCullough ML, Thun MJ, Calle EE. Folate nutrition and prostate cancer incidence in a large cohort of US men. Am J Epidemiol. 2006. 163(11): 989-96.
DOI: 10.1093/aje/kwj126
[56] Weinstein SJ, Hartman TJ, Stolzenberg-Solomon R, et al. Null association between prostate cancer and serum folate, vitamin B(6), vitamin B(12), and homocysteine. Cancer Epidemiol Biomarkers Prev. 2003. 12(11 Pt 1): 1271-2.
[57] Collin SM, Metcalfe C, Refsum H, et al. Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2010. 19(6): 1632-42.
DOI: 10.1158/1055-9965.EPI-10-0180
[58] Ledesma MC, Jung-Hynes B, Schmit TL, Kumar R, Mukhtar H, Ahmad N. Selenium and vitamin E for prostate cancer: post-SELECT (Selenium and Vitamin E Cancer Prevention Trial) status. Mol Med. 2011. 17(1-2): 134-43.
DOI: 10.2119/molmed.2010.00136
[59] Schrauzer GN. Selenium and cancer: a review. Bioinorg Chem. 1976. 5(3): 275-81.
DOI: 10.1016/S0006-3061(00)82026-8
[60] Blot WJ, Li JY, Taylor PR, et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst. 1993. 85(18): 1483-92.

Artículos Relacionados:

Trabajo Original: Folic acid-deficient diet during gestation and post-weaning alters Pomc gene and protein expression in rat offspring

Bruna Morais Faleiros de Paula , Paula Lumy Takeuchi , Helio Vannucchi

Publicado: 2019-03-19 /

Revisión: Suplementación con ácido fólico y prevención de recurrencia de adenomas colorrectales; revisión sistemática

Publicado: 2021-09-28 /

Revisión: Revisión sistemática del efecto de los folatos y otros nutrientes relacionados en la función cognitiva del adulto mayor

Publicado: 2021-09-28 /

Trabajo Original: Micronutrient recommendations and policies in Spain; the cases of iodine, folic acid and vitamin D

Publicado: 2021-10-05 /

Trabajo Original: A pilot study of folic acid supplementation for improving homocysteine levels, cognitive and depressive status in eating disorders

Publicado: 2021-10-25 /

Revisión: Mediterranean diet adherence and prostate cancer risk

Publicado: 2021-11-25 /

Trabajo Original: Undernutrition, serum vitamin B12, folic acid and depressive symptoms in older adults

Publicado: 2021-12-01 /

Trabajo Original: Folic acid and vitamin B12 as biomarkers of morbidity and mortality in patients with septic shock

Yénifer Gamarra-Morales , Jorge Molina-López , Lourdes Herrera-Quintana , Héctor Vázquez-Lorente , Elena Planells

Publicado: 2021-01-10 /

Carta Editor: Metaanálisis en red o network meta-analysis y su aplicación clínica

Raúl Alberto Aguilera-Eguía , Héctor Fuentes-Barría , Cristian Yáñez-Baeza , Víctor Pérez-Galdavini , Gloria Inostroza-Reyes , Ángel Roco-Videla

Publicado: 2022-04-15 /

Carta Editor: Diferencias metodológicas entre una revisión sistemática con metaanálisis y una revisión sistemática con metaanálisis en red

Raúl Alberto Aguilera-Eguía , Héctor Fuentes-Barría , Cristian Yáñez-Baeza , Víctor Pérez-Galdavini , Gloria Inostroza-Reyes , Ángel Roco-Videla

Publicado: 2022-04-20 /

Carta Editor: Supuestos metodológicos que otorgan validez a una revisión sistemática con metaanálisis en red o “network meta-analysis”

Raúl Alberto Aguilera-Eguía , Gloria Inostroza-Reyes , Héctor Fuentes-Barría , Ángel Roco-Videla

Publicado: 2023-01-27 /

Carta Editor: Efectos modificadores que se oponen al supuesto de homogeneidad en una revisión sistemática con metaanálisis en red

Raúl Alberto Aguilera-Eguía , Gloria Inostroza-Reyes , Héctor Fuentes-Barría , Ángel Roco-Videla

Publicado: 2023-01-27 /

Carta Editor: Aplicaciones clínicas del metaanálisis en red: una herramienta para la toma de decisiones clínicas

Raúl Alberto Aguilera-Eguía , Ángel Roco Videla , Héctor Fuentes-Barría , Víctor Pérez-Galdavini

Publicado: 2024-01-29 /

Artículos más populares

Revisión: Relación entre la dieta, aspectos nutricionales y la calidad del sueño en población pediátrica

.La relación entre la dieta y el sueño ha sido esc...

Publicado: 2023-06-08

Artículo Especial: Consenso del grupo de trabajo de los trastornos de la conducta alimentaria de SENPE (GTTCA-SENPE). Evaluación y tratamiento médico-nutricional en la anorexia nerviosa. Actualización 2023

La anorexia nerviosa (AN) es una enfermedad de ori...

Publicado: 2024-02-06

Editorial: ¿Por qué debemos incorporar la determinación del ángulo de fase por impedancia bioeléctrica a nuestra práctica habitual en nutrición clínica?

Publicado: 2024-03-18

Una cookie o galleta informática es un pequeño archivo de información que se guarda en su navegador cada vez que visita nuestra página web. La utilidad de las cookies es guardar el historial de su actividad en nuestra página web, de manera que, cuando la visite nuevamente, ésta pueda identificarle y configurar el contenido de la misma en base a sus hábitos de navegación, identidad y preferencias. Las cookies pueden ser aceptadas, rechazadas, bloqueadas y borradas, según desee. Ello podrá hacerlo mediante las opciones disponibles en la presente ventana o a través de la configuración de su navegador, según el caso. En caso de que rechace las cookies no podremos asegurarle el correcto funcionamiento de las distintas funcionalidades de nuestra página web. Más información en el apartado “POLÍTICA DE COOKIES” de nuestra página web.