Número de descargas:
4575
Número de visitas:
1800
Compártelo:
Background & aims: Several authors have reported low folate intake in patients with eating disorders (ED). This vitamin plays an essential role in synthesis reactions for neurotransmitters and structural elements of neurons, and therefore its deficiency has been associated with the presence of different disorders linked to mental function. The aim of this study was to determine the effect of folic acid supplementation on homocysteine levels and the cognitive and depressive status of a group of patients with eating disorders with low folate intake. Subjects/methods: The study was designed as a randomised, prospective clinical trial, which included 24 participants assigned to two treatment groups for six months: supplemented group (SG) (10 mg/day of folic acid [ACFOL®]) and a placebo group (PG). Both groups maintained their medical, dietary and psychological treatment. At baseline and end of the intervention, anthropometric, dietary and biochemical parameters (plasma homocysteine [Hcy], serum and red blood cell folate) were recorded. Cognitive and depressive status questionnaires were administered (Stroop Test, Trail Making Test and Beck Depression Inventory). Results: Twenty-two patients completed the study (SG: 12, PG: 10, mean age: 24.2 ± 8.8 years, BMI 18.9 ± 3.5 kg/m2). The SG significantly increased their serum and red blood cell folate levels and lowered Hcy levels (9.4 ± 2.4 μmol/l vs. 7.5 ± 1.7 μmol/l, P < 0.01). The SG also significantly improved most of their test scores for cognitive and depressive status. The PG showed no significant changes in any of the evaluated variables. Conclusions: The results show that folic acid supplementation may be used as another tool within the comprehensive and multidisciplinary treatment applied to patients with ED.
Palabras Clave: Folate. Cognitive function. Eating disorders. Depression. Homocysteine.
Adriana Viñas , Araceli Benavides , Thais Ramírez
María Soledad Cruz-sáez , Aitziber Pascual Jimeno , Anna Wlodarczyk , Rocío Polo-lópez , Enrique Echeburúa Odriozola
Borja Romero-gonzález , Rafael Arcangel Caparros-gonzalez , Helen Strivens Vilchez , María Isabel Peralta-ramírez
Rosa María Martínez García , Ana Isabel Jiménez Ortega , Ana M. López Sobaler , Rosa M. Ortega
Virgilio Hernando-Requejo
Enrique Ramón-Arbués , Blanca Martínez Abadía , José Manuel Granada López , Emmanuel Echániz Serrano , Begoña Pellicer García , Raúl Juárez Vela , Sandra Guerrero Portillo , Minerva Saéz Guinoa
Lucía Arias-Fernández , Esther López García , Ellen A. Struijk , Fernando Rodríguez Artalejo , Alberto Lana Pérez
Amanda Ribamar , Beatriz Almeida , Andressa Soares , Beatriz Peniche , Patrícia Jesus , Sabrina Pereira da Cruz , Andréa Ramalho
Ana M. López-Sobaler , Ana María Lorenzo-Mora , María Dolores Salas-González , África Peral Suárez , Aránzazu Aparicio , Rosa M. Ortega
Luis A. Moreno-Aznar , María del Carmen Vidal Carou , Ana M. López-Sobaler , Gregorio Varela Moreiras , José Manuel Moreno Villares
Tania Arauco Lozada , Patricia Garrido Carrasco , Andreu Farran Codina
Luis Adolfo Santos-Calderón , Juan Manuel Vargas Morales , Omar Sánchez-Armáss Capello , Margarita Terán-García , Patricia Elizabeth Cossío-Torres , Marisol Vidal Batres , Joan D. Fernandez-Ballart , Celia Aradillas García
Adriana Fabiola García-Martínez , Martha Patricia Hernández-Valdez , Arnulfo L´Gamiz-Matuk , Diego Incontri-Abraham , Antonio Ibarra
Marina Redruello Requejo , Alejandra Carretero Krug , María de Lourdes Samaniego Vaesken , Teresa Partearroyo Cediel , Gregorio Varela Moreiras
Ying-Rui Tian , Chun-Yan Deng , He-Chuan Xie , Qian-Jing Long , Yuan Yao , Yan Deng , Hao Zhao , Yong Li , Hui Liu , Lun Xiao
Tuğçe Akıllıoğlu , Murat Baş , Gizem Köse
Rosa M. Martínez-García , Ana Isabel Jiménez Ortega , Ana María Lorenzo-Mora , Laura María Bermejo
Miguel Alejandro Atencio-Osorio , Hugo Alejandro Carrillo-Arango , Robinson Ramírez-Vélez
Mihrican Kacar , Nural Erzurum Alim
Background: overweight and obesity have been incre...
Objetivo: el presente estudio tiene como objetivo...