Nutrición Hospitalaria 04908 / http://dx.doi.org/10.20960/nh.04908

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Combined intervention strategy for reversing iron-deficiency anaemia and deficiency in psychomotor development in chronic malnutrition

Ricardo Sevilla Paz Soldán, Nazaret Pantoja Bustamante, Miguel Guzmán-Rivero, Aleida Verduguez-Orellana, Gerard Sevilla Encinas

Prepublicado: 2024-06-24

Publicado: 2024-07-26

VOLUMEN 41, NÚM. 4, julio-agosto (2024), PAG. 866-872

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Background: chronic iron-deficiency anaemia in children has a negative impact on neuronal and cognitive development. Despite current knowledge on this subject, in Bolivia iron intake along the psychomotor development stimulation as part of a comprehensive rehabilitation process for children with severe chronic malnutrition is not yet used. Objective: to evaluate the effect of a neurorestorative diet, consisting of iron supplements and other micronutrients, along with psychomotor stimulation in preschool children with chronic malnutrition, iron-deficiency anaemia and severe psychomotor delay. Patients and methods: twenty-four children between 1 and 56 months of age admitted to the integral nutritional recovery centre (INRC), Paediatric Hospital of Cochabamba, Bolivia were included. A strategy of intervention was applied consisting of nutritional replenishment through the administration of elaborated meals prepared from local foods with high heme and non-heme iron concentration, added with vegetables plus the administration of micronutrient´s supplementation and the psychomotor stimulation. Anthropometric indices, psychomotor and biochemical parameters were measured at four times points, during the hospitalisation period. Results: at the beginning, the anthropometric and psychomotor parameters were decreased (between -2 and -3 z score and below 50 % respectively). Combined strategy intervention with iron and other micronutrients together photons produced significant changes between the evaluated time points, both in anthropometric and psychomotor parameters, although these changes were less than expected. Conclusions: the combined strategy used in this study allowed recovery from the anaemia and minimal growth due to the low birth weight or chronic malnutrition. However, the intervention was insufficient to achieve a complete recovery.

Palabras Clave: Anaemia. Iron replacement. Psychomotor development.

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Bibliografía
Artículos Relacionados

WHO. The global prevalence of anaemia in 2019. [Online].; 2020 [cited 2023 march15]. Available from: https://www.who.int/data/gho/data/themes/topics/anaemia_in_women

_and_children#:~:text=In%202019%2C%20global%20anaemia%20prevalence,39.1%25)%20in%20pregnant%20women.

Instituto Nacional de Estadística INE. La anemia en niños disminuyó en 7,6 puntos porcentuales. [Online].; 2018 [cited 2023 February 12]. Available from: https://www.ine.gob.bo/index.php/la-anemia-en-ninos-disminuyo-en-76-puntos-porcentuales/.

Lozoff B. Iron deficiency and child development. Food Nutr Bull. 2007, 28(4 Suppl):S560-71.
DOI: 10.1177/15648265070284S409

Suarez Sanabria N, García Paz CB. Implications of malnutrition in the psychomotor development of children under five years Rev. chil. nutr.2017,44(2): 125-130. doi.:10.4067/S0717-75182017000200002.
DOI: 10.4067/S0717-75182017000200002

Toxqui L, De Piero A, Courtois V, Bastida S, Sánchez-Muniz FJ, Vaquero MP. Iron deficiency and overload. Implications in oxidative stress and cardiovascular health. Nutr Hosp. 2010;25(3):350-365. doi.:10.3305/nh.2010.25.3.4583.

Stanco GG. Intellectual operation and scholastic yield in children with anemia and iron deficiency. Colombia Médica. 2007, 38(Supl.1):24-33. Available from: http://www. scielo.org.co/scielo.php?script=sci_arttext&pid=S1657-95342007000500005&lng=en.

Archivos Latinoamericanos de Nutrición. Metabolismo del hierro: conceptos actuales sobre un micronutriente esencial. [Online].; 2003 [cited 2023 febrero 5. Available from: http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0004-06222003000200002.

Boccio J, Salgueiro J, Lysionek A, Zubillaga M, Goldman C, Weill R, Caro R. Iron metabolism: current concepts of an essential micronutrient. ALAN. 2003, 53(2):119-132. Available from: http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0004-06222003000200002&lng=es&tlng=es.

Zabaleta N, Astete -Robilliard L. Effect of anemia on child development: long-term consequences. Rev. perú. med. exp. salud publica. 2017,34(4):716-722. doi.:10.17843/rpmesp.2017.344.3251.
DOI: 10.17843/rpmesp.2017.344.3346

García Hernández Y, González Hernández R, González Pérez M, Aznar García E. Desarrollo neural y deficiencia de hierro. Rev CENIC. Ciencias Biológicas. 2005,36 Available from: https://www.redalyc.org/pdf/1812/181220525103.pdf.

Lozoff B, Jimenez E, Wolf AW. Long-term developmental outcome of infants with iron deficiency. N Engl J Med. 1991 Sep 5;325(10):687-94.
DOI: 10.1056/NEJM199109053251004

Sevilla Paz Soldán R, Zalles Cueto L, Chevalier P, Parent G, Erostegui Revilla C. Serrano Caballero E. Community integral multidimensional strategy in chronic malnutrition. Gac Med Bol. 2020,42(1):38-46. Available from: http://www.scielo.org.bo/scielo.php?pid=S1012-29662019000100007&script=sci_arttext
DOI: 10.47993/gmb.v42i1.53

de Andraca I, Pino P, de la Parra A, Rivera F, Castillo M. Factores de riesgo para el desarrollo psicomotor en lactantes nacidos en óptimas condiciones biológicas [Risk factors for psychomotor development among infants born under optimal biological conditions]. Rev Saude Publica. 1998 Apr;32(2):138-47. Spanish.
DOI: 10.1590/S0034-89101998000200006

Cioni G, Sgandurra G. Normal psychomotor development. Handb Clin Neurol. 2013,111:3-15.
DOI: 10.1016/B978-0-444-52891-9.00001-4

Trumbo P, Schlicker S, Yates AA, Poos M; Food and Nutrition Board of the Institute of Medicine, The National Academies. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J Am Diet Assoc. 2002,102(11):1621-30.
DOI: 10.1016/S0002-8223(02)90346-9

Nyaradi A, Li J, Hickling S, Foster J, Oddy WH. The role of nutrition in children's neurocognitive development, from pregnancy through childhood. Front Hum Neurosci. 2013,26(7):97.
DOI: 10.3389/fnhum.2013.00097

Tooley UA, Bassett DS, Mackey AP. Environmental influences on the pace of brain development. Nat Rev Neurosci. 2021,22:372–384. doi.:10.1038/s41583-021-00457-5.
DOI: 10.1038/s41583-021-00457-5

Porras CA, Rouault TA. Iron Homeostasis in the CNS: An Overview of the Pathological Consequences of Iron Metabolism Disruption. Int J Mol Sci. 2022; 23(9):4490. doi.:10.3390/ijms23094490.
DOI: 10.3390/ijms23094490

Cusick SE, Georgieff MK, Rao R. Approaches for Reducing the Risk of Early-Life Iron Deficiency-Induced Brain Dysfunction in Children. Nutrients. 2018,10(2):227.
DOI: 10.3390/nu10020227

Rao R., Tkac I., Townsend E.L., Gruetter R., Georgieff M.K. Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus. J. Nutr. 2003,133:3215–3221.
DOI: 10.1093/jn/133.10.3215

Naeser MA, Saltmarche A, Krengel MH, Hamblin MR, Knight JA. Improved cognitive function after transcranial, light-emitting diode treatments in chronic, traumatic brain injury: two case reports. Photomed Laser Surg. 2011,29(5):351-8.
DOI: 10.1089/pho.2010.2814

Naeser MA, Zafonte R, Krengel MH, Martin PI, Frazier J, Hamblin MR, Knight JA, Meehan WP 3rd, Baker EH. Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study. J Neurotrauma. 2014,31(11):1008-17.
DOI: 10.1089/neu.2013.3244

Barrett DW, Gonzalez-Lima F. Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans. Neuroscience. 2013,230:13-23.
DOI: 10.1016/j.neuroscience.2012.11.016

Vlasova RM, Wang Q, Willette A, Styner MA, Lubach GR, Kling PJ, Georgieff MK, Rao RB, Coe CL. Infantile Iron Deficiency Affects Brain Development in Monkeys Even After Treatment of Anemia. Front Hum Neurosci. 2021,15:624107.
DOI: 10.3389/fnhum.2021.624107

Miller JL. Iron deficiency anemia: a common and curable disease. Cold Spring Harb Perspect Med. 2013,3(7):a011866.
DOI: 10.1101/cshperspect.a011866

Li, Nan, Hang An, Ming Jin, Zhiwen Li, Yali Zhang, Le Zhang, Jianmeng Liu, Rongwei Ye. 2022. "Association of Infants Small for Gestational Age with Anemia under Five Years Old in Two Large Longitudinal Chinese Birth Cohorts" Nutrients 2022,14,5:1006. doi.:10.3390/nu14051006.

Tiwari AK, Mahdi AA, Chandyan S, Zahra F, Godbole MM, Jaiswar SP, Srivastava VK, Negi MP. Oral iron supplementation leads to oxidative imbalance in anemic women: a prospective study. Clin Nutr. 2011,30(2):188-93.
DOI: 10.1016/j.clnu.2010.08.001

Puga AM, Samaniego-Vaesken ML, Montero-Bravo A, Ruperto M, Partearroyo T, Varela-Moreiras G. Iron Supplementation at the Crossroads of Nutrition and Gut Microbiota: The State of the Art. Nutrients. 2022,14(9):1926.
DOI: 10.3390/nu14091926

Fernald LC, Kariger P, Hidrobo M, Gertler PJ. Socioeconomic gradients in child development in very young children: evidence from India, Indonesia, Peru, and Senegal. Proc Natl Acad Sci U S A. 2012,109(suppl 2): 17273–17280.
DOI: 10.1073/pnas.1121241109

Hamadani J D, Tofail F, Huda S N, Alam D S, Ridout D A, Attanasio O, Grantham-McGregor S M. Cognitive Deficit and Poverty in the First 5 Years of Childhood in Bangladesh. PEDIATRICS, 2014,134(4), e1001–e1008.
DOI: 10.1542/peds.2014-0694

Celhay P, Martinez S, Vidal C. Measuring socioeconomic gaps in nutrition and early child development in Bolivia. Int J Equity Health. 2020,19(1):122.
DOI: 10.1186/s12939-020-01197-1

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