Número de descargas: 2309 Número de visitas: 3490 Citas: 0
Compártelo:
Introduction: The α-lipoic acid (ALA) has been used as a treatment to reduce oxidative damage in Systemic Arterial Hypertension (SAH), but there are no in vivo studies reporting the effect of its mechanism of action on iron metabolism. Objective: To evaluate the antioxidant effect of α-lipoic acid on Blood cell count (CBC) and iron metabolism in hypertensive subjects with or without anemia. Method: Double-blind, randomized, placebo-controlled clinical trial. The sample consisted of 60 hypertensive patients that were randomly divided into treatment group (n = 32), receiving 600 mg / day of ALA for twelve weeks and control group (n = 28), receiving placebo for the same period. Blood cell count, serum iron, ferritin, Latent Iron-Binding Capacity (LIBC), Total Iron-Binding Capacity (TIBC), Transferrin Saturation Index (TSI) and transferrin were assessed before and after intervention. To assess changes between groups, the Student t-test and ANOVA were used, adopting a significance level of 5%. Results: After intervention, ALA supplementation showed a statistically significant (p < 0.05) association with the reduction of total leukocytes, increase in the number of neutrophils and reductions in the serum levels of iron and TSI. Conclusion: Oral administration of ALA as a therapeutic adjuvant changes the hematologic response of white blood cells and reduces the absorption of iron. It is observed that the mechanism of metals chelation by lipoic acid may be responsible for these changes and, consequently, could trigger a condition of iron deficiency anemia in hypertensive individuals.
Palabras Clave: Lipoic Acid. Iron. Hypertension. Anemia.
Cristian Álvarez , Rodrigo Ramírez-campillo , Andrea Vallejos-rojas , Javiera Jaramillo-gallardo , Carlos Salas Bravo , Johnattan Cano-montoya , Carlos Celis-Morales
Candelaria Martín-González , Ana María Torres-Vega , Emilio González-Reimers , Geraldine Quintero-platt , Camino Fernández-rodríguez , Julio Alvisa-negrín , Adnan Hawari-meilud , Francisco Santolaria-fernández
Rosa M. Ortega Anta , Ana Isabel Jiménez-Ortega , José Miguel Perea Sánchez , Esther Cuadrado Soto , Ana M. López Sobaler
Norma Isela Vizuet Vega , Teresa Shamah-Levy , Elsa Berenice Gaona Pineda , Lucía Cuevas Nasu , Ignacio Méndez Gómez-humarán
Sergio Cuellar-rufino , Mónica Navarro-meza , Pablo García-solís , Irene Xochihua-rosas , Omar Arroyo-helguera
Jesús Román Martínez Álvarez , Antonio Villarino Marín , Rosa Mª García Alcón , Noemí López Ejeda , Mª Dolores Marrodán Serrano
Liejy Agnes Landim , Marcia Luiza Dos Santos Beserra Pessoa , Amanda De Castro Amorim Serpa Brandão , Marcelo Antonio Morgano , Marcos Antônio De Mota Araújo Marcos Antônio De Mota Araújo , Maurisrael De Moura Rocha , José Alfredo Gomes Arêas , Regilda Saraiva Dos Reis Moreira-araújo
María Fabiana Pirán Arce , Laura Rosana Aballay , Jorge Leandro Leporati , Alicia Navarro , Myriam Forneris
Julio Alfonso Piña López , José Moral De La Rubia , José Luis Ybarra Sagarduy , Dacia Yurima Camacho Mata , José Luis Masud-yunes Zárraga
Lorena Fernández-palacios , Gaspar Ros-Berruezo , Elsa Barrientos-augustinus , Elizabeth Jirón De Caballero , Carmen Frontela-saseta
Sibila Reck De Jesus , Bruna Pessoa Alves , Anieli Golin , Schott Mairin , Leonardo dos Santos Dachi , Andrea Rodrigues Marques , Elisângela Colpo
Zia Ud Din , Lubna Pervez , Muhammad Abbas , Imran Khan , Zafar Iqbal , Mudassar Iqbal
Fabiano Ferreira de Lima , Taís Feitosa Da Silva , Manoel Miranda Neto , Luciana Tavares Toscano , Cássia Surama Oliveira da Silva , Alexandre Sérgio Silva
David Rincón-Pabón , Yeraldin Urazán-Hernández , Jhonatan Gonzalez-Santamaria
Pedro Delgado-Floody , Felipe Caamaño Navarrete , Constanza Palomino-Devia , Daniel Jerez-Mayorga , Cristian Martínez-Salazar
Enrique Ramón-Arbués , Blanca Martínez-Abadía , Teresa Gracia-Tabuenca , Cristina Yuste-Gran , Begoña Pellicer-García , Raúl Juárez-Vela , Sandra Guerrero-Portillo , Minerva Sáez-Guinoa
María Morales Suárez-Varela , M.ª Carmen Mohino Chocano , Carla Soler Quiles , Agustín Llopis-Morales , Isabel Peraita-Costa , Agustín Llopis-González
María Suárez Arana , Ernesto González-mesa
Cinthya Vásquez-Velásquez , Gustavo F. Gonzales
María Robles Rebollo , María Inmaculada López Aliaga , Javier Díaz Castro , Jorge Moreno-Fernández , María José Muñoz Alférez
Kliver Antonio Marin , Helen Hermana Miranda Hermsdorf , Fabiane Aparecida Canaan Rezende , Maria do Carmo Gouveia Peluzio , Antônio José Natali
María Eugenia López Valverde , Carlos Jericó Alba , José Antonio García Erce
Priscila Stefani Vallejos Vildoso , Jorge da Silva Pinho Jr , Ana Paula Azevedo de Mattos , Gabrielle de Souza Rocha , Sergio Girão Barroso , Grazielle Vilas Boas Huguenin , Andréa Cardoso de Matos
Javier Blasco-Alonso , Raquel Gil-Gómez , Ana García Ruiz , Marta Cortés Hernández , Guiomar Gutiérrez Schiaffino
Zhengfu Zhang , Zhen Fan , Jun Zhang
Wellington Segheto , João Carlos Bouzas Marins , Paulo Roberto dos Santos Amorim , Amanda Botelho Franco , Marisa Assis Almeida , Nádia Vieira Alves Alvarenga , Luciana Moreira Lima
Iris Paola Guzmán-Guzmán , Pedro Delgado-Floody , Ilse Adriana Gutiérrez-Pérez , Felipe Caamaño-Navarrete , Daniel Jerez-Mayorga , Óscar Zaragoza-García , Isela Parra-Rojas
Salma Izamar Cortés Álvarez , Yunue Flores-Ruelas , Mario del Toro-Equihua , Libertad Pérez-Manzo , Iván Delgado-Enciso , Carmen Alicia Sánchez-Ramírez
Alejandra Cantoral , Ivonne Ramírez-Silva , Héctor Lamadrid-Figueroa , Dirk L Christensen , Ib C. Bygbjerg , Louise Groth-Grunnet , Karoline Kragelund Nielsen , Adriana Granich-Armenta , Laura Ávila-Jiménez , Juan Ángel Rivera Dommarco
Lisha Mu , Pingping Yu , Huini Xu , Tao Gong , Dan Chen , Jie Tang , Yujia Zou , Huakun Rao , Ying Mei , Lihong Mu
Luz M. Caballero-Apaza , Rubén Vidal-Espinoza , Tania Padilla-Cáceres , Rossana Gómez-Campos , Marco Cossio-Bolaños
Jie Tang , Dan Chen , Lisha Mu , Pingping Yu , Tao Gong , Huini Xu , Ziyan Zhang , Shuwen Cai , Lihong Mu , Ying Mei
Natalia Rodríguez-Núñez , Ángel Roco-Videla
Michel Alberto Garat Escudero , Ángel Roco-Videla
Xing Tan , Yu Tian , Zonghong Li , Siyuan Cui , Zhenzhen Wang , Yanfeng Zhou , Zhaoxia Liu , Fansheng Kong , Yan Wang , Ruirong Xu
Edith Tello-Palma , Martiza Choque-Quispe , Myrian Pacheco-Tanaka , Walter Zamalloa-Cuba , Marleni Valencia-Pacho , Teófilo Donaires-Flores , Elva Macedo-Enriquez , Adelaida Viza-Salas , Amalia Quispe-Romero , Wilbert Paredes-Ugarte , Marco Cossio-Bolaños , Rossana Gómez-Campos
Ana Paula Caio Zidório , Kenia Mara Baiocchi de Carvalho , Eliane Said Dutra
Alvin R. Acosta Magaña , Armando García Guerra , Veronica Mundo Rosas , Amado D. Quezada Sánchez , Carlos Galindo Gómez , Fabiola Mejía Rodríguez , Ana Cecilia Fernández Gaxiola
Yi Wu , Jie Tang , Dan Chen , Yujia Zou , Pingping Yu , Huini Xu , Shuwen Cai , Yanni Ren , Ying Mei , Lihong Mu
Yujia Zou , Jie Tang , Fan Zhang , Dan Chen , Lisha Mu , Huini Xu , Pingping Yu , Yanni Ren , Ying Mei , Lihong Mu
Jialong Pan , Yonghua Liao , Qing Huang , Guoye Ji , Rujun Dai , Dongyun Lin
Ricardo Sevilla Paz Soldán , Nazaret Pantoja Bustamante , Miguel Guzmán-Rivero , Aleida Verduguez-Orellana , Gerard Sevilla Encinas
Antecedentes y objetivo: la endometriosis es un tr...