Nutrición Hospitalaria 05079
/
http://dx.doi.org/10.20960/nh.05079
Resumen|
PDF (ENGLISH)
Trabajo Original
A nomogram combining prognostic nutritional index and platelet lymphocyte ratio predicts postoperative pulmonary infection following D2 radical gastrectomy for gastric cancer
Xinghao Ma, Xiumin Lu, Xiaoyang Jiang, Jiajia Wang, Tingting Wang, Li Zhang
Prepublicado: 2024-04-26
Número de descargas:
4
Número de visitas:
43
Citas:
0
Compártelo:
Introduction: the prognostic nutritional index (PNI) and platelet-lymphocyte ratio (PLR) have been found to correlate with outcomes following radical gastrectomy for gastric cancer (GC). Objectives: to construct a nomogram combining PNI and PLR for individually forecasting the risk of postoperative pulmonary infection (POI) following D2 radical gastrectomy for GC. Methods: retrospectively, clinical data was gathered from 404 patients treated with D2 radical gastrectomy for GC. The study used multivariate logistic regression analysis to screen independent risk factors for POI after surgery. Subsequently, a nomogram was developed based on the above factors to forecast the POI probability accurately. Results: the multivariate logistic regression analysis identified age, PNI, PLR, CA199 level, ASA score, and ICU treatment as independent risk variables for POI following D2 radical gastrectomy (p < 0.001 or 0.05). The nomogram's area under the receiver operating characteristic curve (AUC) for predicting the risk of POI was 0.736 (95 % confidence interval (CI) = 0.678-0.794). The nomogram was internally validated using the bootstrap approach, involving repeated sampling 1000 times. The result yielded a concordance index (c-index) of 0.707 (95 % CI = 0.705-0.709). The calibration curves demonstrated an excellent concordance between the predicted values of the nomogram and the observed values. The nomogram's clinical value was shown to be high using decision analysis curves. Conclusions: a nomogram combining PNI and PLR is a dependable tool for forecasting the probability of POI following D2 radical gastrectomy for GC.
Palabras Clave: Gastric cancer. Prognostic nutritional index. Platelet lymphocyte ratio. Pulmonary infection. Nomogram.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71:209-49.
DOI: 10.3322/caac.21660
DOI: 10.3322/caac.21660
Cao W, Chen HD, Yu YW, Li N and Chen WQ. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. Chin Med J (Engl) 2021;134:783-91.
DOI: 10.1097/CM9.0000000000001474
DOI: 10.1097/CM9.0000000000001474
Japanese Gastric Cancer Association. Japanese Gastric Cancer Treatment Guidelines 2021 (6th edition). Gastric Cancer 2023;26:1-25.
DOI: 10.1007/s10120-022-01331-8
DOI: 10.1007/s10120-022-01331-8
Shibata C, Ogawa H, Nakano T, Koyama K, Yamamoto K, Nagao M, et al. Influence of age on postoperative complications especially pneumonia after gastrectomy for gastric cancer. BMC Surg 2019;19:106.
DOI: 10.1186/s12893-019-0573-x
DOI: 10.1186/s12893-019-0573-x
Kiuchi J, Komatsu S, Ichikawa D, Kosuga T, Okamoto K, Konishi H, et al. Putative risk factors for postoperative pneumonia which affects poor prognosis in patients with gastric cancer. Int J Clin Oncol 2016;21:920-6.
DOI: 10.1007/s10147-016-0987-8
DOI: 10.1007/s10147-016-0987-8
Lawrence VA, Hilsenbeck SG, Mulrow CD, Dhanda R, Sapp J and Page CP. Incidence and hospital stay for cardiac and pulmonary complications after abdominal surgery. J Gen Intern Med 1995;10:671-8.
DOI: 10.1007/BF02602761
DOI: 10.1007/BF02602761
Thompson DA, Makary MA, Dorman T and Pronovost PJ. Clinical and economic outcomes of hospital acquired pneumonia in intra-abdominal surgery patients. Ann Surg 2006;243:547-52.
DOI: 10.1097/01.sla.0000207097.38963.3b
DOI: 10.1097/01.sla.0000207097.38963.3b
Tu RH, Lin JX, Li P, Xie JW, Wang JB, Lu J, et al. Prognostic significance of postoperative pneumonia after curative resection for patients with gastric cancer. Cancer Med 2017;6:2757-65.
DOI: 10.1002/cam4.1163
DOI: 10.1002/cam4.1163
Suzuki S, Kanaji S, Matsuda Y, Yamamoto M, Hasegawa H, Yamashita K, et al. Long-term impact of postoperative pneumonia after curative gastrectomy for elderly gastric cancer patients. Ann Gastroenterol Surg 2018;2:72-8.
DOI: 10.1002/ags3.12037
DOI: 10.1002/ags3.12037
Kanda M, Ito S, Mochizuki Y, Teramoto H, Ishigure K, Murai T, et al. Multi-institutional analysis of the prognostic significance of postoperative complications after curative resection for gastric cancer. Cancer Med 2019;8:5194-201.
DOI: 10.1002/cam4.2439
DOI: 10.1002/cam4.2439
Li QG, Li P, Tang D, Chen J and Wang DR. Impact of postoperative complications on long-term survival after radical resection for gastric cancer. World J Gastroenterol 2013;19:4060-5.
DOI: 10.3748/wjg.v19.i25.4060
DOI: 10.3748/wjg.v19.i25.4060
Sun F, Zhang C, Liu Z, Ai S, Guan W and Liu S. Controlling Nutritional Status (CONUT) score as a predictive marker for short-term complications following gastrectomy of gastric cancer: a retrospective study. BMC Gastroenterol 2021;21:107.
DOI: 10.1186/s12876-021-01682-z
DOI: 10.1186/s12876-021-01682-z
Lee JY, Kim HI, Kim YN, Hong JH, Alshomimi S, An JY, et al. Clinical Significance of the Prognostic Nutritional Index for Predicting Short- and Long-Term Surgical Outcomes After Gastrectomy: A Retrospective Analysis of 7781 Gastric Cancer Patients. Medicine (Baltimore) 2016;95:e3539.
DOI: 10.1097/MD.0000000000003539
DOI: 10.1097/MD.0000000000003539
Inaoka K, Kanda M, Uda H, Tanaka Y, Tanaka C, Kobayashi D, et al. Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer. World J Gastroenterol 2017;23:2519-26.
DOI: 10.3748/wjg.v23.i14.2519
DOI: 10.3748/wjg.v23.i14.2519
Kwak JS, Kim SG, Lee SE, Choi WJ, Yoon DS, Choi IS, et al. The role of postoperative neutrophil-to-lymphocyte ratio as a predictor of postoperative major complications following total gastrectomy for gastric cancer. Ann Surg Treat Res 2022;103:153-9.
DOI: 10.4174/astr.2022.103.3.153
DOI: 10.4174/astr.2022.103.3.153
Gulmez S, Senger A, Uzun O, Ozduman O, Ofluoglu C, Subasi I, et al. Comparative Analysis of Preoperative Ratio Based Markers in Predicting Postoperative Infectious Complications After Gastrectomy. Pol Przegl Chir 2022;95:1-5.
DOI: 10.5604/01.3001.0015.9662
DOI: 10.5604/01.3001.0015.9662
Sun X, Liu X, Liu J, Chen S, Xu D, Li W, et al. Preoperative neutrophil-to-lymphocyte ratio plus platelet-to-lymphocyte ratio in predicting survival for patients with stage I-II gastric cancer. Chin J Cancer 2016;35:57.
DOI: 10.1186/s40880-016-0122-2
DOI: 10.1186/s40880-016-0122-2
Nozoe T, Ninomiya M, Maeda T, Matsukuma A, Nakashima H and Ezaki T. Prognostic nutritional index: a tool to predict the biological aggressiveness of gastric carcinoma. Surg Today 2010;40:440-3.
DOI: 10.1007/s00595-009-4065-y
DOI: 10.1007/s00595-009-4065-y
Ignacio de Ulibarri J, Gonzalez-Madrono A, de Villar NG, Gonzalez P, Gonzalez B, Mancha A, et al. CONUT: a tool for controlling nutritional status. First validation in a hospital population. Nutr Hosp 2005;20:38-45.
Horan TC, Andrus M and Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309-32.
DOI: 10.1016/j.ajic.2008.03.002
DOI: 10.1016/j.ajic.2008.03.002
Xi X, Yang MX, Wang XY and Shen DJ. Predictive value of prognostic nutritional index on infection after radical gastrectomy: a retrospective study. J Gastrointest Oncol 2022;13:569-80.
DOI: 10.21037/jgo-22-192
DOI: 10.21037/jgo-22-192
Bora Makal G and Yildirim O. Are the C-reactive protein/albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (NLR) novel inflammatory biomarkers in the early diagnosis of postoperative complications after laparoscopic sleeve gastrectomy? Obes Res Clin Pract 2020;14:467-72.
DOI: 10.1016/j.orcp.2020.07.003
DOI: 10.1016/j.orcp.2020.07.003
Muscaritoli M, Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, et al. ESPEN practical guideline: Clinical Nutrition in cancer. Clin Nutr 2021;40:2898-913.
DOI: 10.1016/j.clnu.2021.02.005
DOI: 10.1016/j.clnu.2021.02.005
Xiao H, Zhou H, Liu K, Liao X, Yan S, Yin B, et al. Development and validation of a prognostic nomogram for predicting post-operative pulmonary infection in gastric cancer patients following radical gastrectomy. Sci Rep 2019;9:14587.
DOI: 10.1038/s41598-019-51227-4
DOI: 10.1038/s41598-019-51227-4
Cho H, Tsuchida K, Iwasaki K and Maezawa Y. Risk factors of post-operative pneumonia in elderly patients with gastric cancer: a retrospective cohort study. Jpn J Clin Oncol 2021;51:1044-50.
DOI: 10.1093/jjco/hyab032
DOI: 10.1093/jjco/hyab032
Xiao Q, Li X, Duan B, Li X, Liu S, Xu B, et al. Clinical significance of controlling nutritional status score (CONUT) in evaluating outcome of postoperative patients with gastric cancer. Sci Rep 2022;12:93.
DOI: 10.1038/s41598-021-04128-4
DOI: 10.1038/s41598-021-04128-4
Arroyo V, Garcia-Martinez R and Salvatella X. Human serum albumin, systemic inflammation, and cirrhosis. J Hepatol 2014;61:396-407.
DOI: 10.1016/j.jhep.2014.04.012
DOI: 10.1016/j.jhep.2014.04.012
Zhang H, Tao Y, Wang Z and Lu J. Evaluation of nutritional status and prognostic impact assessed by the prognostic nutritional index in children with chronic kidney disease. Medicine (Baltimore) 2019;98:e16713.
DOI: 10.1097/MD.0000000000016713
DOI: 10.1097/MD.0000000000016713
Xiao Y, Wei G, Ma M, Liu D, Chen P, Quan H, et al. Association among prognostic nutritional index, post-operative infection and prognosis of stage II/III gastric cancer patients following radical gastrectomy. Eur J Clin Nutr 2022;76:1449-56.
DOI: 10.1038/s41430-022-01120-7
DOI: 10.1038/s41430-022-01120-7
Mungan I, Dicle CB, Bektas S, Sari S, Yamanyar S, Cavus M, et al. Correction to: Does the preoperative platelet-tolymphocyte ratio and neutrophil-tolymphocyte ratio predict morbidity after gastrectomy for gastric cancer? Mil Med Res 2020;7:12.
DOI: 10.1186/s40779-020-00242-y
DOI: 10.1186/s40779-020-00242-y
Kim EY, Lee JW, Yoo HM, Park CH and Song KY. The Platelet-to-Lymphocyte Ratio Versus Neutrophil-to-Lymphocyte Ratio: Which is Better as a Prognostic Factor in Gastric Cancer? Ann Surg Oncol 2015;22:4363-70.
DOI: 10.1245/s10434-015-4518-z
DOI: 10.1245/s10434-015-4518-z
Mungan I, Dicle CB, Bektas S, Sari S, Yamanyar S, Cavus M, et al. Does the preoperative platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio predict morbidity after gastrectomy for gastric cancer? Mil Med Res 2020;7:9.
DOI: 10.1186/s40779-020-00234-y
DOI: 10.1186/s40779-020-00234-y
Zheng CF, Liu WY, Zeng FF, Zheng MH, Shi HY, Zhou Y, et al. Prognostic value of platelet-to-lymphocyte ratios among critically ill patients with acute kidney injury. Crit Care 2017;21:238.
DOI: 10.1186/s13054-017-1821-z
DOI: 10.1186/s13054-017-1821-z
Chen C, Gu L, Chen L, Hu W, Feng X, Qiu F, et al. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Potential Predictors of Prognosis in Acute Ischemic Stroke. Front Neurol 2020;11:525621.
DOI: 10.3389/fneur.2020.525621
DOI: 10.3389/fneur.2020.525621
Zhou X, Du Y, Huang Z, Xu J, Qiu T, Wang J, et al. Prognostic value of PLR in various cancers: a meta-analysis. PLoS One 2014;9:e101119.
DOI: 10.1371/journal.pone.0101119
DOI: 10.1371/journal.pone.0101119
Mohri Y, Tanaka K, Toiyama Y, Ohi M, Yasuda H, Inoue Y, et al. Impact of Preoperative Neutrophil to Lymphocyte Ratio and Postoperative Infectious Complications on Survival After Curative Gastrectomy for Gastric Cancer: A Single Institutional Cohort Study. Medicine (Baltimore) 2016;95:e3125.
DOI: 10.1097/MD.0000000000003125
DOI: 10.1097/MD.0000000000003125
Miyamoto R, Inagawa S, Sano N, Tadano S, Adachi S and Yamamoto M. The neutrophil-to-lymphocyte ratio (NLR) predicts short-term and long-term outcomes in gastric cancer patients. Eur J Surg Oncol 2018;44:607-12.
DOI: 10.1016/j.ejso.2018.02.003
DOI: 10.1016/j.ejso.2018.02.003
Kubota T, Hiki N, Nunobe S, Kumagai K, Aikou S, Watanabe R, et al. Significance of the inflammation-based Glasgow prognostic score for short- and long-term outcomes after curative resection of gastric cancer. J Gastrointest Surg 2012;16:2037-44.
DOI: 10.1007/s11605-012-2036-x
DOI: 10.1007/s11605-012-2036-x
Horn F, Henze C and Heidrich K. Interleukin-6 signal transduction and lymphocyte function. Immunobiology 2000;202:151-67.
DOI: 10.1016/S0171-2985(00)80061-3
DOI: 10.1016/S0171-2985(00)80061-3
Artículos Relacionados:
Trabajo Original: What are the most effective methods for assessment of nutritional status in outpatients with gastric and colorectal cancer?
Publicado: 2021-10-20 / http://dx.doi.org/
Trabajo Original: Gastric cancer and associated factors in hospitalized patients
Publicado: 2021-12-01 / http://dx.doi.org/
Trabajo Original: Risk and protective factors for gastric metaplasia and cancer: a hospital-based case-control study in Ecuador
Publicado: 2022-01-13 / http://dx.doi.org/
Trabajo Original: A novel nomogram based on the nutritional risk screening 2002 score to predict survival in hepatocellular carcinoma treated with transarterial chemoembolization
Xinxin Chen
Publicado: 2021-12-02 / http://dx.doi.org/10.20960/nh.03983
Revisión: Vitamin D and gastric cancer — A systematic review and meta-analysis
Xi Zhao , Jie Wang , Long Zou
Publicado: 2022-08-24 / http://dx.doi.org/10.20960/nh.04410
Trabajo Original: Protective effect of dietary micronutrients on gastric cancer risk among Jordanians
Sabika Allehdan , Shatha S. Hammad , Razan M. Alatrash , Tareq Al-Jaberi , Ahmad Hushki , Shirin Yacoub , Mohammad Dahoud , Tahra Elobeid , Reema Tayyem Tayyem
Publicado: 2022-11-23 / http://dx.doi.org/10.20960/nh.04547
Trabajo Original: Efectividad de la inmunonutrición en el manejo nutricional perioperatorio del cáncer gástrico
Ángel Martínez González , José Llópiz Castedo , Pedro Rodeiro Escobar , Manuella González Nunes , Bárbara Fernández López , María de los Ángeles García Cardoner , Francisco Javier Fraile Amador , Samuel Rodriguez Zorrilla , María Inmaculada Martínez González , Santiago Enrique Rodeiro Marta
Publicado: 2023-09-14 / http://dx.doi.org/10.20960/nh.04934
Trabajo Original: Agreements between GLIM using left calf circumference as criterion for reduced muscle mass and PG-SGA, and GLIM using ASMI for the diagnosis of malnutrition in gastric cancer patients
Liang Fu , Xiaoqian Xu , Yaoqi Zhang , Jianxiang Jin , Sha Zhu , Haixia Shi , Qiaohui Guan , Lijun Zhang , Yanting Hu , Bo Zhuang , Lushan Zheng , Xianghong Ye
Publicado: 2023-11-06 / http://dx.doi.org/10.20960/nh.05024
Artículos más populares
Revisión: Ayuno intermitente: efectos en diversos escenarios clínicos
Introducción: los esquemas de ayuno intermitente (...
Trabajo Original: Body mass index and risk of inflammatory breast disease: a Mendelian randomization study
Introduction: in previous studies, obesity was ide...
-
Licencia creative commons: Open Access bajo la licencia Creative Commons 4.0 CC BY-NC-SA
https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
Editado en Madrid por:
