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Introduction: Patients with chronic kidney disease (CKD) show an increase in bowel aerobic bacteria that produce uremic toxins and decreased anaerobic bacteria as bifidobacteria and lactobacillus. The latter can be used as probiotics. The probiotic with greater availability in Mexico, is the lactobacillus casei shirota (LcS), currently there is no known LcS specified dose that produces a benefit to the patient with CKD. Objective: To determine the effectiveness of two different LcS doses in achieving a decrease in urea concentrations of at least 10% in patients with KDOQI stage 3 and stage 4 CKD. Metodology: A simple randomized, controlled clinical trial. Outpatients treated at the National Institute of Medical Sciences and Nutrition Salvador Zubirán in México D.F. Patients were provided the LcS, as follows: Group A: 8 x 109 colony-forming units (CFU) and Group B: 16 x 109 CFU. Patients were followed-up for eight weeks, and baseline and final samples were obtained to calculate the basal and final concentrations, respectively, of blood urea and serum creatinine (CrS). During the follow-up, both groups consumed a diet of 30 kcal/kg/weight and 0.8 g/kg/weight of protein, and a food diary was made to assess both the adherence to the diet and LcS. Results: Thirty patients with CKD were evaluated. When analyzing the percentage change between the different doses, a decrease > 10% was found in the blood urea concentrations for patients treated with the 16 x 109 dose, which was significant with respect to the baseline measurement. Conclusion: There was a > 10% decrease in the serum urea concentrations with LcS in patients with stage 3 and 4 CRF.
Palabras Clave: Ureas. Uremic toxins. Dose. Probiotics. Lactobacillus casei Shirota.
Mª José Sendrós Madroño
Lourdes Travieso Suárez , Pilar Quijada Fraile , Consuelo Pedrón Giner
María D. Ballesteros Pomar , Elena González Arnaiz
Ana Isabel Jiménez Ortega , Rosa María Martínez García , Marta Velasco Rodríguez-Belvis , Ana Belén Martínez Zazo , María Dolores Salas-González , Esther Cuadrado-Soto
Francisco Guarner
Jerome Sarris , Bincy Mehta , Veronika Óvári , Inmaculada Ferreres Giménez
Kaiwen Sun , Zhenzhu Liu , Hongyan Wang
Sonia López-Cisneros , Ailema González-Ortiz , Samuel Ramos-Acevedo , Ángeles Espinosa-Cuevas
Julián Herrera Mejía , Arnulfo Ramos-Jiménez , Florinda Jiménez Vega , Rocío Campos Vega , Aaron F. González Córdova , Abraham Wall-Medrano
YanPing Liu , Dejian Ma , XiYan Wang , YunZhi Fang
Qiwei Xie , Jiatian Yuan , Yaoweng Wang
Juan José Silva Rodríguez
Secundino Cigarrán Guldrís
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Objective: To evaluate the role of probiotics in t...