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Introduction: Atopic dermatitis (AD) is a disease that mainly affects the pediatric population involving chronic and repetitive inflammatory skin manifestations. Its evolution is known as atopic march, which is characterized by the occurrence of respiratory and food allergies. Aim: To carry out a classical review of the state-of-theart scientific literature regarding the effect of probiotics on the treatment of children with AD. Methods: Searches were conducted in Medline and Lilacs through the portals PubMed (http://www.ncbi.nlm. nih.gov/pubmed/) and SciELO (http://www.scielo.br). There was a selection of the available publications in the period from 2001 to 2011, using the keywords atopic dermatitis and probiotics (in English and in Portuguese). Results: After applying the inclusion and exclusion criterias, we selected 12 case-control studies which were conducted in four European countries and Australia. The methodological quality of the studies was assessed according to the STROBE recommendations. Assessment of agreement among researches in classifying the quality of the articles showed excellent agreement (k = 1.00, 95%) with a total of 9 papers at B level. The majority of the studies (75%) indicated a beneficial biological effect of probiotics on AD, including protection against infections, enhancement of the immune response, inflammation reduction and changes in gut the flora. The remaining studies showed no beneficial effects according to the outcomes of interest. Conclusion: The majority of the studies in the scientific literature in this review showed improvements in some inflammatory parameters and in intestinal microbiota and not exactly, changes in clinical parameters. However, the biological effects observed in most of them suggest the possibility of benefits of the use of probiotics as an adjunvant in the treatment of AD.
Palabras Clave: Atopic dermatitis. Alergy. Probiotics.
Mª José Sendrós Madroño
Ana Isabel Jiménez-Ortega , Rosa María Martínez García , María José Quiles Blanco , Jamil Abdel Majid Abu Naji , María José González Iglesias
María Dolores Ballesteros Pomar , Elena González Arnaiz
Jorge Gabriel Ruiz Sánchez , Samara Palma Milla , Beatriz Pelegrina Cortés , Bricia López-Plaza , Laura María Bermejo López , Carmen Gómez Candela
Ana Isabel Jiménez-Ortega , Rosa María Martínez García , Marta Velasco Rodríguez-Belvis , Ana Belén Martínez Zazo , María Dolores Salas-González , Esther Cuadrado-Soto
Francisco Guarner
Ana Maria Campos Martinez , Carmen Elizabeth Fernández Marín , Aida Ruiz López , Isabel Cubero Millán , José Uberos Fernández
Kaiwen Sun , Zhenzhu Liu , Hongyan Wang
Sonia López-Cisneros , Ailema González-Ortiz , Samuel Ramos-Acevedo , Ángeles Espinosa-Cuevas
Julián Herrera Mejía , Arnulfo Ramos-Jiménez , Florinda Jiménez Vega , Rocío Campos Vega , Aaron F. González Córdova , Abraham Wall-Medrano
YanPing Liu , Dejian Ma , XiYan Wang , YunZhi Fang
Cristina Benítez Provedo , María Angeles Martínez Ibeas , Rebeca Losada del Pozo , Ana María Montes Arjona , Miriam Blanco Rodríguez , Genoveva del Río Camacho
Qiwei Xie , Jiatian Yuan , Yaoweng Wang
Merve Tokpunar , K. Esen Karaca Çelik , Murat Baş , Hakan Kuleaşan , Aylin Korkut Altıntaş
Gözde Okburan , Murat Baş , Sultan Ogmen
Fatma Özgüç Çömlek , Muslu Kazım Körez
Sibel Bulut , Seray Kabaran
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