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Nutrición Hospitalaria 04521 / http://dx.doi.org/10.20960/nh.04521
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Trabajo Original

Protective effect of manganese treatment on insulin resistance in HepG2 hepatocytes

Qingwen Zhang, Shili Song, Ruyue Jiang, Jingyi Zhang, Lixin Na

Prepublicado: 2023-06-26
Publicado: 2023-07-28
VOLUMEN 40, NÚM. 4, julio-agosto (2023), PAG. 746-754

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Objectives: manganese (Mn) is closely related to type 2 diabetes mellitus and insulin resistance (IR), but the exact mechanism is unclear. This study aimed to explore the regulatory effects and mechanism of Mn on IR using hepatocyte IR model induced by high palmitate (PA), high glucose (HG) or insulin. Methods: HepG2 cells were exposed to PA (200 μM), HG (25 mM) or insulin (100 nM) respectively, alone or with 5 μM Mn for 24 hours. The expression of key proteins in insulin signaling pathway, intracellular glycogen content and glucose accumulation, reactive oxygen species (ROS) level and Mn superoxide dismutase (MnSOD) activity were detected. Results: compared with control group, the expression of phosphorylated protein kinase B (Akt), glycogen synthase kinase-3β (GSK-3β) and forkhead box O1 (FOXO1) in the three IR groups was declined, and this decrease was reversed by Mn. The reduction of intracellular glycogen content and increase in glucose accumulation in IR groups were also inhibited by Mn. Additionally, the production of ROS was increased in IR models, compared with normal control group, while Mn reduced the excessive production of ROS induced by PA, HG or insulin. However, Mn did not alter the activity of MnSOD in the three IR models. Conclusion: this study demonstrated that Mn treatment can improve IR in hepatocytes. The mechanism is probably by reducing the level of intracellular oxidative stress, enhancing the activity of Akt/GSK-3β/FOXO1 signal pathway, promoting glycogen synthesis, and inhibiting gluconeogenesis.

Palabras Clave: Insulin resistance. Type 2 diabetes. Manganese.



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Carmen Celada Roldán , Jaime López Díez , Faustino Rider , María Ángeles Cerezuela Abarca , Almudena Tárraga Marcos , Pedro Juan Tárraga López

Publicado: 2023-05-24 / http://dx.doi.org/10.20960/nh.04786
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Trabajo Original: Relationship between serum omentin-1 levels and nascent metabolic syndrome in Caucasian patients with obesity

Daniel de Luis Román , Olatz Izaola Jáuregui , David Primo

Publicado: 2024-04-21 / http://dx.doi.org/10.20960/nh.05275
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Trabajo Original: Prácticas alimentarias en la diabetes tipo 2: construcción, validez y confiabilidad de una escala

Marcela Bañuelos-Fonseca , Lilia Susana Gallardo-Vidal , Iris Pineda-Mújica , Adriana Jheny Rodríguez-Méndez , Prishila Danae Reyes-Chávez , Benito Quintero-Valdez

Publicado: 2024-01-18 / http://dx.doi.org/10.20960/nh.05147
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Revisión: Intermittent fasting for glycemic control in patients with type 2 diabetes: a meta-analysis of randomized controlled trials

Xiaoyi Huang , Guihao Huang , Guiju Wei

Publicado: 2024-09-10 / http://dx.doi.org/10.20960/nh.05521
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