Número de descargas: 5758 Número de visitas: 5017 Citas: 0
Compártelo:
Background: Insulin resistance (IR) is associated with a higher risk of multiple diseases and its early detection would allow to minimize the associated risk; the presence of acanthosis nigricans (AN) it’s associated to the presence of IR. Objective: To evaluate the sensibility and specificity of AN to diagnose IR in a group of Chilean patients. Methods: We designed a cross-sectional study and it was included subjects that were attended at the Center for the Attention of Metabolic Diseases at the Faculty of Medicine, University of Chile. Sixty subjects (18-60 years age) were included. It was determined BMI and diagnosed AN and skin phototype; blood samples were taken and calculated the HOMA-IR. The normality of the variables where analyzed by Kolmogorov-Smirnov test. There were used χ2 and the diagnostic concordance between AN and IR was determined using the Kappa index and Pearson’s correlation. Sensibility, specificity, positive and negative predictive value were calculated and accepted p < 0.05. Results: The IR diagnose was 67% and AN was 43%. The major proportion of subjects diagnosed as positive for IR were also positive for AN (84.6%). The sensibility of AN to find IR was an 84% and specificity was 100%. Positive and negative predictive values were 100% and 89% respectively. It was observed a positive association between BMI and HOMA-IR (r = 0.674; r2 = 0.454; p < 0.001). Conclusion: To detect acanthosis nigricans in Chilean population may be effective for the early diagnose of insulin resistance and, therefore, reduce the associated cost of the late treatment of glucose metabolic disturbances.
Palabras Clave: Acanthosis nigricans. Insulin resistance. Sensibility. Specificity. Chilean adults.
Fabián Vásquez , Erik Diaz , Lydia Lera , Jorge Meza , Katherine Curi , Jorge Torres , Raquel Burrows
Marta Milla-tobarra , Antonio García-hermoso , Noelia Lahoz-garcía , Blanca Notario-pacheco , Lidia Lucas-de La Cruz , Diana P. Pozuelo-carrascosa , María José García-meseguer , Vicente Martínez-vizcaíno
Ana Isabel Jiménez-Ortega , Rosa María Martínez García , María José Quiles Blanco , Jamil Abdel Majid Abu Naji , María José González Iglesias
Larissa Pessoa Vila Nova , Cristiane Maria Araújo Tavares De Sá , Maria Cleide Freire Clementino Da Silva , Marinaldo Freire Lustosa , Rafael Augusto Batista De Medeiros , Daniel Calado Brito , Maria Goretti Pessoa de Araújo Burgos
Hugo Martínez-rojano , María Luisa Pizano-zárate , Bernarda Sánchez-jiménez , Reyna Sámano , Armando López-portillo
Raquel Jiménez-talamantes , Jennifer Rizk Hernández , Joan Quiles Izquierdo
Norma Cecilia Serrano , Adriana Robles Silva , Diana Paola Suárez , Edna Magaly Gamboa-delgado , Doris Cristina Quintero-lesmes
Antonia Caroline Diniz Brito Pinheiro , Natalino Salgado Filho , Ana Karina Teixeira da Cunha França , Andrea Martins Melo Fontenele , Alcione Miranda dos Santos
Jaime Alberto Bricio-barrios , Mario del Toro-Equihua , Miguel Huerta , Mónica Ríos-Silva , Yolitzy Cárdenas , Marisa López , Alfredo Saavedra-Molina , Zorayda Urzúa , Mónica Ortiz-Mesina , Felipa Andrade-Urzúa , Jonathan Alexis García-Contreras , Xóchitl Trujillo
Daniel de Luis Román , Emilia Gómez Hoyos , Ana Ortolá Buigues , Esther Delgado , Gonzalo Díaz , Beatriz Torres Torres , Juan José López
Ana Claudia Rossini Venturini , Pedro Pugliesi Abdalla , André Pereira dos Santos , Thiago Cândido Alves , Anderson dos Santos Carvalho , Jorge Mota , José Augusto Gonçalves Marini , Franciane Goés Borges , Dalmo Roberto Lopes Machado
Salesa Barja , Catalina Le Roy , Cecilia Sepúlveda , Maria Luisa Guzmán , Marithza Olivarez , María José Figueroa
Sondos Flieh , Esther González Gil , Maria Luisa Miguel-berges , Luis A. Moreno Aznar
David Pacheco , Olatz Izaola , David Primo Martín , Daniel de Luis Román
Daniel de Luis Román , David Primo Martín , Olatz Izaola Jáuregui
Beatriz Teresita Martín-Márquez , Flavio Sandoval-Garcia , Mónica Vazquez-Del Mercado , Erika-Aurora Martínez-García , Fernanda-Isadora Corona-Meraz , Ana-Lilia Fletes-Rayas , Soraya-Amalí Zavaleta-Muñiz
María Dolores Salas-González , Elena Rodríguez-Rodríguez , Ana Isabel Jiménez-Ortega , Liliana Guadalupe González-Rodríguez , Ana M. López-Sobaler
Shanshan Chen , Yuanye Ma , Haojie Li , Hui Lang , Yongchun Li , Jie Wu , Min Zhou , Yingxin He , Yuan Liu , Erfeng Guo
Daniel de Luis Román , Olatz Izaola , David Primo Martín , Emilia Gómez Hoyos , Beatriz Torres , Juan José López
Susana del Refugio Ruiz González , Rebeca Monroy Torres , Juan Manuel Malacara , Rodolfo Guardado Mendoza
Mariela Vega-Cárdenas , Jorge Flores-Sánchez , María Lucina Torres-Rodriguez , Omar Sánchez-Armáss Capello , Juan Manuel Vargas-Morales , Patricia Elizabeth Cossío-Torres , Margarita Terán-García , Celia Aradillas-García
Qingwen Zhang , Shili Song , Ruyue Jiang , Jingyi Zhang , Lixin Na
José Antonio Palma-Jacinto , Isela Santiago-Roque , María del Rocío Coutiño-Rodríguez , Omar Elind Arroyo-Helguera
Maribel Calderón , Gianella Plaza , Marisol Gómez , Bárbara Samith , Victoria Pinto , Ximena Martínez , Daniela Sara , Guadalupe Echeverría , Mariana Calzada , Loni Berkowitz , Andrea von Schultzendorff , Nuria Pedrals , Marcela Bitran , Attilio G. Rigotti
María Dolores Salas-González , Viviana Loria-Kohen , Ana Isabel Jiménez-Ortega , Ana M. López-Sobaler
Daniel de Luis Román , Olatz Izaola Jáuregui , David Primo
Antecedentes y objetivo: la endometriosis es un tr...