Nutrición Hospitalaria 00027 / http://dx.doi.org/10.20960/nh.27

Revisión

Chromium supplementation in patients with type 2 diabetes and high risk of type 2 diabetes: a meta-analysis of randomized controlled trials

Ismael San Mauro-martin, Ana María Ruiz-león, María Alicia Camina-martín, Elena Garicano-vilar, Luis Collado-yurrita, Beatriz De Mateo-silleras, María De Paz Redondo Del Río

VOLUMEN 33, NÚM. 1, enero-febrero (2016), PAG. 156-161

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Introduction: Chromium is an essential trace mineral for carbohydrate and lipid metabolism, which is currently prescribed to control diabetes mellitus. Results of previous systematic reviews and meta-analyses of chromium supplementation and metabolic profiles in diabetes have been inconsistent.Aim: The objective of this meta-analysis was to assess the effects on metabolic profiles and safety of chromium supplementation in type 2 diabetes mellitus and cholesterol.Methods: Literature searches in PubMed, Scopus and Web of Science were made by use of related terms-keywords and randomized clinical trials during the period of 2000-2014.Results: Thirteen trials fulfilled the inclusion criteria and were included in this systematic review. Total doses of Cr supplementation and brewer’s yeast ranged from 42 to 1,000 μg/day, and duration of supplementation ranged from 30 to 120 days. The analysis indicated that there was a significant effect of chromium supplementation in diabetics on fasting plasma glucose with a weighted average effect size of -29.26 mg/dL, p = 0.01, CI 95% = −52.4 to -6.09; and on total cholesterol with a weighted average effect size of -6.7 mg/dL, p = 0.01, CI 95% = −11.88 to -1.53.Conclusions: The available evidence suggests favourable effects of chromium supplementation on glycaemic control in patients with diabetes.

Palabras Clave: Type 2 diabetes; Hyperglycaemia; HbA1c; Cholesterol; Chromium; Randomized controlled trial

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Imanparast, Fatemeh, Javaheri, Javad, Kamankesh, Fatemeh, Rafiei, Fatemeh, Salehi, Ashraf, Mollaaliakbari, Zeinab, Rezaei, Fatemeh, Rahimi, Abbas, Abbasi, Elnaz (2020) The effects of chromium and vitamin D3 co-supplementation on insulin resistance and tumor necrosis factor-alpha in type 2 diabetes: a randomized placebo-controlled trial. Applied Physiology, Nutrition, and Metabolism

Moradi, Fardin, Maleki, Vahid, Saleh‐Ghadimi, Sevda, Kooshki, Fatemeh, Pourghassem Gargari, Bahram (2019) Potential roles of chromium on inflammatory biomarkers in diabetes: A Systematic. Clinical and Experimental Pharmacology and Physiology

Östman, Elin, Samigullin, Azat, Heyman-Lindén, Lovisa, Andersson, Kristina, Björck, Inger, Öste, Rickard, Humpert, Per M., Buchowski, Maciej S. (2020) A novel nutritional supplement containing amino acids and chromium decreases postprandial glucose response in a randomized, double-blind, placebo-controlled study. PLOS ONE

Hekmat-Ardakani, Alireza, Morshed-Behbahani, Bahar, Rahimi-Ardabili, Hania, Ayati, Mohammad Hossein, Namazi, Nazli (2023) The effects of dietary supplements and natural products targeting glucose levels: an overview. Critical Reviews in Food Science and Nutrition

Ouali, Karim, Ibrahmi, Btihaj AL, Bouchefra, Said, Bour, Abdellatif (2024) Micronutrition and diabetes: a new view at prevention and treatment. Italian Journal of Medicine

Vajdi, Mahdi, Musazadeh, Vali, Karimi, Arash, Heidari, Hajar, Tarrahi, Mohammad Javad, Askari, Gholamreza (2023) Effects of Chromium Supplementation on Lipid Profile: an Umbrella of Systematic Review and Meta-analysis. Biological Trace Element Research

Khodavirdipour, Amir, Haddadi, Fatemeh, Keshavarzi, Shiva (2020) Chromium Supplementation; Negotiation with Diabetes Mellitus, Hyperlipidemia and Depression. Journal of Diabetes & Metabolic Disorders

Abu-zaiton, Ahmed, Almuhur, Rana, Algaramseh, Ayah, Alwardat, Dima (2021) WITHDRAWN: The impact of chromium supplementation on carbohydrates, liver function, kidney function and testosterone levels in diabetic rats. Materials Today: Proceedings

Beeraka, Narasimha M., Tomilova, Irina K., Batrak, Galina A., Zhaburina, Maria V., Nikolenko, Vladimir N., Sinelnikov, Mikhail Y., Mikhaleva, Liudmila M. (2022) Recent Insights into the Nutritional Antioxidant Therapy in Prevention and Treatment of Diabetic Vascular Complications: A Comprehensive Review. Current Medicinal Chemistry

Tsave, O., Salifoglou, A. (2021) Biomimetic activity of soluble, well-defined, aqueous Ti(IV)-citrate species toward adipogenesis. An in vitro study. Journal of Inorganic Biochemistry

Fakharzadeh, Saideh, Kalanaky, Somayeh, Argani, Hassan, Dadashzadeh, Simin, Torbati, Peyman Mohammadi, Nazaran, Mohammad Hassan, Basiri, Abbas (2021) Ameliorative effect of a nano chromium metal–organic framework on experimental diabetic chronic kidney disease. Drug Development Research

Zeilstra, Dennis, Younes, Jessica A, Brummer, Robert J, Kleerebezem, Michiel (2018) Perspective: Fundamental Limitations of the Randomized Controlled Trial Method in Nutritional Research: The Example of Probiotics. Advances in Nutrition

Barceloux DG. Chromium. J Toxicol Clin Toxicol 1999;37:173-94.
DOI: 10.1081/CLT-100102418

Boon PE, Te Biesebeek JD, Sioen I, Huyberchts I, De Neve M, Amiano P, et al. Long-term dietary exposure to chromium in young children living in different European countries. EFSA Journal 2010.

Vicent JB. The nutritional biochemistry of chromium (III). Elsevier; 2007. 4. EFSA Panel on Contaminants in the Food Chain (EFSA CONTAM Panel). Scientific opinion on the risks to public health related to the presence of chromium in food and drinking water. EFSA Journal 2014;12(3):3595-261.

EFSA. Scientific opinion of the Panel on Food Additives and Nutrient Sources added to Food on chromium nitrate as a source of chromium added for nutritional purposes to food supplements following a request from the European Commission. EFSA Journal 2009;1111:1-19.

Melo V, Cuamatzi O. Bioquímica de los procesos metabólicos. Barcelona and México D.F.: Reverte; 2007.

Fébel H, Szegedi B, Huszár S. Absorption of inorganic, trivalent and hexavalent chromium following oral and intrajejunal doses in rats. Acta Vet Hung 2001;49:203-9.
DOI: 10.1556/004.49.2001.2.10

Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17(1):1-12.

Whitehead A, Whitehead J. A general parametric approach to the meta analysis of randomized clinical trials. Stat Med 1991;10:1665-77.
DOI: 10.1002/sim.4780101105

De Simonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88.
DOI: 10.1016/0197-2456(86)90046-2

Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta analysis detected by a simple, graphical test. Br Med J 1997;315:629-34.
DOI: 10.1136/bmj.315.7109.629

Jain SK, Kahlon G, Morehead L, Dhawan R, LIeblong B, Stapleton T, et al. Effect of chromium dinicocysteinate supplementation on circulating levels of insulin, TNF-α, oxidative stress, and insulin resistance in type 2 diabetic subjects: randomized, double-blind, placebo-controlled study. Mol Nutr Food Res 2012;56:1333-41.
DOI: 10.1002/mnfr.201100719

Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal Vl. Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes. J Trace Elem Med Biol 2011;25:149-53.
DOI: 10.1016/j.jtemb.2011.03.003

Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8:636-43.
DOI: 10.1089/dia.2006.8.636

Geohas J, Daly A, Juturu V, Finch M, Komorowski JR. Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Am J Med Sci 2007;333:145-53.
DOI: 10.1097/MAJ.0b013e318031b3c9

Guimarães MM, Martins Silva Carvalho AC, Silva MS. Chromium nicotinate has no effect on insulin sensitivity, glycemic control, and lipid profile in subjects with type 2 diabetes. J Am Coll Nutr 2013;32:243-50.
DOI: 10.1080/07315724.2013.816598

Racek J, Trefil L, Rajdl D, Mudrova V, Hunter D, Senft V. Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus. Biol Trace Elem Res 2006;109:215-30.
DOI: 10.1385/BTER:109:3:215

Hosseinzadeh P, Javanbakht MH, Mostafavi SA, Djalali M, Derakhshanian H, Hajianfar H, et al. Brewer’s Yeast improves glycemic Indices in type 2 diabetes mellitus. Int J Prev Med 2013;4:1131-8.

Martin J, Wang ZQ, Zhang XH, Wachtel D, Volaufova J, Matthews DE, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006;29:1826-32.
DOI: 10.2337/dc06-0254

Kleefstra N, Houweling ST, Bakker SJ, Verhoeven S, Gans ROB, Jong BM, et al. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo controlled trial. Diabetes Care 2007;30:1092-6.
DOI: 10.2337/dc06-2192

Pei D, Hsieh CH, Hung YJ, Li JC, Lee CH, Kuo SW. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism 2006;55:923-7.
DOI: 10.1016/j.metabol.2006.02.021

Gunton JE, Cheung NW, Hitchman R, Hams G, O´Sullivan C, Foster Powell K, et al. Chromium supplementation does not improve glucose tolerance, insulin sensitivity, or lipid profile: a randomized, placebo controlled, double-blind trial of supplementation in subjects with impaired glucose tolerance. Diabetes Care 2005;28:712-3.
DOI: 10.2337/diacare.28.3.712

Albarracin CA, Fuqua BC, Evans JL, Goldfine ID. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes Metab Res Rev 2008;24:41-51.
DOI: 10.1002/dmrr.755

Kleefstra N, Houweling ST, Jansman FGA, Groenier KH, Gans ROB, Jong BM, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29:521-5.
DOI: 10.2337/diacare.29.03.06.dc05-1453

Suksomboon N, Poolsupt N, Yuwanakorn A. Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes. Journal of Clinical Pharmacy and Therapeutics 2014;39:292 306.
DOI: 10.1111/jcpt.12147

Abdollahi M, Farshchi A, Nikfar S, Seyedifar M. Effect of chromium on glucose and lipid profiles in patients with type 2 diabetes; a meta-analysis review of randomized trials. J Pharm Pharmaceut Sci 2013;16(1):99-114.
DOI: 10.18433/J3G022

Patal PC, Cardino MT, Jimeno CA. A meta-analysis on the effect of chromium picolinate on glucose and lipid profiles among patients with type 2 diabetes mellitus. Philipp J IntMed 2010;48(1):32-37.

Balk EM, Tatsioni A, Lichtenstein AH, Lau J, Pitta AG. Effect of chromium supplementation on glucose metabolism and lipids a systematic review of randomized controlled trials. Diabetes Care 2007;30(8):2154-63.
DOI: 10.2337/dc06-0996

Bailey CH. Improved meta-analytic method show no effect of chromium supplements on fasting glucose. Biol Trace Elem Res 2014;157:1-8.
DOI: 10.1007/s12011-013-9863-9

Broadhurst CL, Domenico P. Clinical studies on chromium picolinate supplementation in diabetes mellitus-a review. Diabetes Technol Ther 2006;8(6):677-87.
DOI: 10.1089/dia.2006.8.677

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