Nuevo Usuario

Recordar Contraseña

Nutrición Hospitalaria 05272 / http://dx.doi.org/10.20960/nh.05272

Resumen| PDF (ENGLISH)

Trabajo Original

The effect of supplementation with prebiotic fiber on the gut microbiota of a group of older people with Parkinson's disease from the city of Santiago de Chile. A pilot study

Paula García Milla, Gema Nieto Martínez, Mario Maulen, Carlos Tapia, Waldo Díaz

Prepublicado: 2025-02-25

Publicado: 2025-04-08

VOLUMEN 42, NÚM. 2, marzo-abril (2025), PAG. 232-242

Logo Descargas Número de descargas: 1638 Logo Visitas Número de visitas: 1009 Citas Citas: 0

Compártelo:

Introduction: Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. It has been demonstrated that there is a correlation between the increase in bacterial abundance and the severity of certain symptoms associated with PD. Aim: the aim of this pilot study was to analyze the effect of supplementation with prebiotic fiber on the gut microbiota (GM) and nutritional status of elderly volunteers with Parkinson's disease. Methodology: this is a pilot study of pre and post intervention with prebiotic fiber. All subjects involved were volunteers with PD, who were given nutritional counseling and gut microbiota measured on time cero and after 30 days of prebiotic fiber intervention. Results: a statistically significant difference was found in calf circumference (p 0.0422) after the intervention with prebiotic fiber. GM analyses show an initial difference in gut bacterial abundance of older people with PD and people without PD. Furthermore, our results showed a difference in bacterial families and genera after the supplementation with prebiotic fiber. in addition, we found a statistically significant difference in the val-ue of circumference calf and a trend in the improvement of body weight, Body mass index (BMI), neck circumference, arm circumference, brachial area, and Diet Quality Questionnaire (DQQ) for older adults. Conclusion: supplementation with 20 g of prebiotic fiber for 30 days could modify the intestinal microbiota, reducing bacterial genera and phylum that are abundant in Park-inson's disease, such as Verrucomicrobia. Therefore, the use of prebiotic fiber could represent an alternative to improve intestinal health and nutritional status of people with Parkinson's disease.

Palabras Clave: Dietary fiber. Inulin. Gastrointestinal microbiome. Parkinson's disease.

Descargar PDF (ENGLISH)

Bibliografía
Artículos Relacionados

Fujio-Vejar S, Vasquez Y, Morales P, Magne F, Vera-Wolf P, Ugalde JA, et al. The gut microbiota of healthy Chilean subjects reveals a high abundance of the phylum Verrucomicrobia. Front Microbiol. 2017 Jun 30;8(JUN).
DOI: 10.3389/fmicb.2017.01221

Adak A, Khan MR. An insight into gut microbiota and its functionalities. Cell Mol Life Sci [Internet]. 2019 Feb 15 [cited 2024 Feb 26];76(3):473–93. Availa-ble from: https://pubmed.ncbi.nlm.nih.gov/30317530/
DOI: 10.1007/s00018-018-2943-4

Álvarez-Calatayud G, Guarner F, Requena T, Marcos A. Dieta y microbiota. Impacto en la salud. Nutr Hosp. 2018 Sep 7;35(6).
DOI: 10.20960/nh.2280

Castillo-Álvarez F, Marzo-Sola ME. Papel de la microbiota intestinal en el desarrollo de diferentes enfermedades neurológicas. Neurología. 2022 Jul 1;37(6):492–8.
DOI: 10.1016/j.nrl.2019.03.017

Bhattarai Y, Kashyap PC. Parkinson’s disease: Are gut microbes involved? Am J Physiol Gastrointest Liver Physiol [Internet]. 2020 Oct 20 [cited 2021 May 12];319(5):G529–40. Available from: https://pubmed.ncbi.nlm.nih.gov/32877215/
DOI: 10.1152/ajpgi.00058.2020

Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Par-kinson’s Disease. Cell [Internet]. 2016 Dec 1 [cited 2022 Jun 7];167(6):1469-1480.e12. Available from: https://pubmed.ncbi.nlm.nih.gov/27912057/
DOI: 10.1016/j.cell.2016.11.018

Hamamah S, Aghazarian A, Nazaryan A, Hajnal A, Covasa M. Role of Microbi-ota-Gut-Brain Axis in Regulating Dopaminergic Signaling. Biomedicines. 2022 Feb 13;10(2):436.
DOI: 10.3390/biomedicines10020436

Góralczyk-Bińkowska A, Szmajda-Krygier D, Kozłowska E. The Microbiota-Gut-Brain Axis in Psychiatric Disorders. Int J Mol Sci [Internet]. 2022 Oct 1 [cited 2024 Feb 26];23(19). Available from: https://pubmed.ncbi.nlm.nih.gov/36232548/
DOI: 10.3390/ijms231911245

Arikan M, Yildiz Z, Kahraman Demir T, Yilmaz NH, Sen A, Hanoglu L, et al. Axillary Microbiota Is Associated with Cognitive Impairment in Parkinson’s Disease Patients. Microbiol Spectr [Internet]. 2022 Feb 23 [cited 2022 Jun 7];10(1). Available from: https://pubmed.ncbi.nlm.nih.gov/35138147/
DOI: 10.1128/spectrum.02358-21

Tian R, Hong J, Zhao J, Zhou D, Liu Y, Jiao Z, et al. Overall Structural Altera-tion of Gut Microbiota and Relationships with Risk Factors in Patients with Metabolic Syndrome Treated with Inulin Alone and with Other Agents: An Open-Label Pilot Study. Mediators Inflamm [Internet]. 2022 May 19 [cited 2022 Jul 28];2022:1–9. Available from: /pmc/articles/PMC9136633/
DOI: 10.1155/2022/2078520

Raymond JL, Morrow K. Dietoterapia. 15°. Elsevier, editor. Barcelona, España: 2021; 2021.

Paz TDSR, De Britto VLS, Yamaguchi B, Israel VL, Swarowsky A, Lourenço Correa C. Hand Function as Predictor of Motor Symptom Severity in Individu-als with Parkinson’s Disease. Gerontology [Internet]. 2021 Apr 1 [cited 2022 Nov 30];67(2):160–7. Available from: https://www.karger.com/Article/FullText/511910
DOI: 10.1159/000511910

Malmstrom TK, Miller DK, Simonsick EM, Ferrucci L, Morley JE. SARC‐F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes. J Cachexia Sarcopenia Muscle [Internet]. 2016 Mar 1 [cited 2022 Nov 30];7(1):28. Available from: /pmc/articles/PMC4799853/
DOI: 10.1002/jcsm.12048

Rubenstein LZ, Harker JO, Salvà A, Guigoz Y, Vellas B. Screening for Under-nutrition in Geriatric PracticeDeveloping the Short-Form Mini-Nutritional As-sessment (MNA-SF). The Journals of Gerontology: Series A [Internet]. 2001 Jun 1 [cited 2022 Nov 30];56(6):M366–72. Available from: https://academic.oup.com/biomedgerontology/article/56/6/M366/526432
DOI: 10.1093/gerona/56.6.M366

Durán Agüero S, Candia P, Mena RP. Validación de contenido de la Encuesta de Calidad de Alimentación del Adulto Mayor (ECAAM). Nutr Hosp [Internet]. 2017 Nov 14 [cited 2022 Nov 30];34(6):1311–8. Available from: https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112017000900009&lng=es&nrm=iso&tlng=es

Lai H, Li Y, He Y, Chen F, Mi B, Li J, et al. Effects of dietary fibers or probiot-ics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023 Dec 31;15(1).
DOI: 10.1080/19490976.2023.2197837

Miranda M V., González FC, Paredes-Godoy OS, Maulén MA, Vásquez† CC, Díaz-Vásquez WA. Characterization of metal(loid)s and antibiotic resistance in bacteria of human gut microbiota from chronic kidney disease subjects. Biol Res [Internet]. 2022 Dec 1 [cited 2024 Feb 28];55(1):1–12. Available from: https://link.springer.com/articles/10.1186/s40659-022-00389-z
DOI: 10.1186/s40659-022-00389-z

Bergström A, Licht TR, Wilcks A, Andersen JB, Schmidt LR, Grønlund HA, et al. Introducing GUt Low-Density Array (GULDA) - a validated approach for qPCR-based intestinal microbial community analysis. FEMS Microbiol Lett. 2012 Dec;337(1):38–47.
DOI: 10.1111/1574-6968.12004

Caporaso JG, Lauber CL, Walters WA, Berg-Lyons D, Lozupone CA, Turn-baugh PJ, et al. Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proc Natl Acad Sci U S A [Internet]. 2011 Mar 15 [cited 2022 Nov 15];108 Suppl 1(Suppl 1):4516–22. Available from: https://pubmed.ncbi.nlm.nih.gov/20534432/
DOI: 10.1073/pnas.1000080107

Zilli Canedo Silva M, Carol Fritzen N, de Oliveira M, Paes da Silva M, Rasmus-sen Petterle R, Teive HA, et al. Protein intake, nitrogen balance and nutritional status in patients with Parkinson’s disease; time for a change? Nutr Hosp. 2015 Jun 1;31(6):2764–70.

SENPE; SEGG. SENPE SOCIEDAD ESPAÑOLA DE NUTRICIÓN PARENTE-RAL Y ENTERAL SEGG SOCIEDAD ESPAÑOLA DE GERIATRÍA Y GE-RONTOLOGÍA.

Budrewicz S, Zmarzły A, Rączka D, Szczepańska A, Koziorowska-Gawron E, Słotwiński K, et al. Clinical and nutritional correlations in Parkinson’s disease: Preliminary report. Advances in Clinical and Experimental Medicine [Internet]. 2019 Feb 1 [cited 2021 Jun 23];28(2):193–8. Available from: https://pubmed.ncbi.nlm.nih.gov/29963785/
DOI: 10.17219/acem/76375

Giuri D, Ravarino P, Tomasini C. L-Dopa in small peptides: an amazing func-tionality to form supramolecular materials. Org Biomol Chem. 2021;19(21):4622–36.
DOI: 10.1039/D1OB00378J

Nagatsu T, Sawada M. L-dopa therapy for Parkinson’s disease: Past, present, and future. Parkinsonism Relat Disord. 2009 Jan;15:S3–8.
DOI: 10.1016/S1353-8020(09)70004-5

Leta V, Klingelhoefer L, Longardner K, Campagnolo M, Levent HÇ, Aureli F, et al. Gastrointestinal barriers to levodopa transport and absorption in Parkinson’s disease. Eur J Neurol. 2023 May 7;30(5):1465–80.
DOI: 10.1111/ene.15734

Laudisio A, Vetrano DL, Meloni E, Ricciardi D, Franceschi F, Bentivoglio AR, et al. Dopaminergic agents and nutritional status in Parkinson’s disease. Move-ment Disorders. 2014 Oct;29(12):1543–7.
DOI: 10.1002/mds.25991

Sharma S, Awasthi A, Singh S. Altered gut microbiota and intestinal permeabil-ity in Parkinson’s disease: Pathological highlight to management. Neurosci Lett. 2019 Nov 1;712:134516.
DOI: 10.1016/j.neulet.2019.134516

Rekdal VM, Bess EN, Bisanz JE, Turnbaugh PJ, Balskus EP. Discovery and in-hibition of an interspecies gut bacterial pathway for Levodopa metabolism. Sci-ence [Internet]. 2019 Jun 14 [cited 2021 Dec 26];364(6445):1055. Available from: /pmc/articles/PMC7745125/
DOI: 10.1126/science.aau6323

Huang Y, Liao J, Liu X, Zhong Y, Cai X, Long L. Review: The Role of Intestinal Dysbiosis in Parkinson’s Disease. Front Cell Infect Microbiol [Internet]. 2021 Apr 22 [cited 2021 Dec 22];11. Available from: https://pubmed.ncbi.nlm.nih.gov/33968794/
DOI: 10.3389/fcimb.2021.615075

van Kessel SP, de Jong HR, Winkel SL, van Leeuwen SS, Nelemans SA, Per-mentier H, et al. Gut bacterial deamination of residual levodopa medication for Parkinson’s disease. BMC Biol [Internet]. 2020 Dec 1 [cited 2022 Jul 13];18(1). Available from: https://pubmed.ncbi.nlm.nih.gov/33076930/
DOI: 10.1186/s12915-020-00876-3

Jameson KG, Hsiao EY. A novel pathway for microbial metabolism of Levodo-pa. Nat Med [Internet]. 2019 Aug 1 [cited 2022 Jul 13];25(8):1195. Available from: /pmc/articles/PMC7004239/
DOI: 10.1038/s41591-019-0544-x

Su H, Chen J, Miao S, Deng K, Liu J, Zeng S, et al. Lotus seed oligosaccharides at various dosages with prebiotic activity regulate gut microbiota and relieve constipation in mice. Food and Chemical Toxicology. 2019 Dec 1;134:110838.
DOI: 10.1016/j.fct.2019.110838

Lan J, Wang K, Chen G, Cao G, Yang C. Effects of inulin and isomalto-oligosaccharide on diphenoxylate-induced constipation, gastrointestinal motili-ty-related hormones, short-chain fatty acids, and the intestinal flora in rats. Food Funct [Internet]. 2020 Oct 1 [cited 2022 Jul 13];11(10):9216–25. Available from: https://pubmed.ncbi.nlm.nih.gov/33030479/
DOI: 10.1039/D0FO00865F

Heaton KW, Radvan J, Cripps H, Mountford RA, Braddon FEM, Hughes AO. Defecation frequency and timing, and stool form in the general population: a prospective study. Gut [Internet]. 1992 [cited 2022 Jul 13];33(6):818. Available from: /pmc/articles/PMC1379343/?report=abstract
DOI: 10.1136/gut.33.6.818

Leiva AM, Martínez-Sanguinetti MA, Troncoso-Pantoja C, Nazar G, Peter-mann-Rocha F, Celis-Morales C. Chile lidera el ranking latinoamericano de prevalencia de enfermedad de Parkinson. Rev Med Chil. 2019 Apr;147(4):535–6.
DOI: 10.4067/S0034-98872019000400535

Nishiwaki H, Ito M, Ishida T, Hamaguchi T, Maeda T, Kashihara K, et al. Meta-Analysis of Gut Dysbiosis in Parkinson’s Disease. Movement Disorders [Inter-net]. 2020 Sep 1 [cited 2021 Dec 26];35(9):1626–35. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/mds.28119
DOI: 10.1002/mds.28119

Nishiwaki H, Hamaguchi T, Ito M, Ishida T, Maeda T, Kashihara K, et al. Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson’s Dis-ease but Not in Rapid-Eye-Movement Sleep Behavior Disorder. mSystems [In-ternet]. 2020 Dec 22 [cited 2022 Jul 30];5(6). Available from: /pmc/articles/PMC7771407/
DOI: 10.1128/mSystems.00797-20

Fang X, Li F jun, Hong D jun. Potential Role of Akkermansia muciniphila in Parkinson’s Disease and Other Neurological/Autoimmune Diseases. Curr Med Sci [Internet]. 2021 Dec 1 [cited 2022 Jul 30];41(6):1172–7. Available from: https://pubmed.ncbi.nlm.nih.gov/34893951/
DOI: 10.1007/s11596-021-2464-5

Yan Z, Yang F, Cao J, Ding W, Yan S, Shi W, et al. Alterations of gut microbio-ta and metabolome with Parkinson’s disease. Microb Pathog. 2021 Nov 1;160:105187.
DOI: 10.1016/j.micpath.2021.105187

Pisciotta MS, Fusco D, Grande G, Brandi V, Lo Monaco MR, Laudisio A, et al. Untangling the relationship between fat distribution, nutritional status and Par-kinson’s disease severity. Aging Clin Exp Res [Internet]. 2020 Jan 1 [cited 2021 Jun 23];32(1):77–84. Available from: https://pubmed.ncbi.nlm.nih.gov/30877644/
DOI: 10.1007/s40520-019-01166-x

Artículos más populares

Artículo Especial: VII Lección Jesús Culebras. Respuesta inflamatoria sistémica y disfunción/ fracaso multiorgánico tras una agresión: implicaciones metabólicas

Ante cualquier agresión, el organismo pone en marc...

Publicado: 2017-01-30

Resumen | PDF

Artículo Especial: VIII Lección Jesús Culebras. Medicina intensiva, nutrición e hiperglucemia: una relación muy estrecha

El paciente crítico presenta una respuesta metaból...

Publicado: 2017-07-28

Resumen | PDF

Trabajo Original: Waist-to-height ratio and its relation with cardiometabolic risk factors in children from Bucaramanga, Colombia

Background: Currently, the waist-to-height ratio (...

Publicado: 2017-02-21

Resumen | PDF

Licencia creative commons: Open Access bajo la licencia Creative Commons 4.0 CC BY-NC-SA
https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode

Editado en Madrid por:

Diseño y Desarrollo web Im3diA comunicación

Trabajo Original

The effect of supplementation with prebiotic fiber on the gut microbiota of a group of older people with Parkinson's disease from the city of Santiago de Chile. A pilot study

Artículos Relacionados:

Artículo Especial: Sumario de recomendaciones nutricionales basadas en la evidencia de la guía de prácti ca clínica para el manejo de pacientes con enfermedad de parkinson

Trabajo Original: Influencia del suplemento con inulina enriquecida con fructooligosacáridos sobre el contenido y la densidad mineral ósea tras el parto y la lactación en ratas

Trabajo Original: Incremento en el consumo de fibra dietética complementario al tratamiento del síndrome metabólico

Trabajo Original: Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients

Trabajo Original: Efecto del consumo de la fibra dietética en la expresión cuantitativa del receptor de butirato GPR43 en colon de ratas

Revisión: Dietary fibre and cardiovascular health

Trabajo Original: Microbiota benefits after inulin and partially hydrolized guar gum supplementation – a randomized clinical trial in constipated women

Trabajo Original: Relationship between body mass index with dietary fiber intake and skinfolds-differences among bodybuilders who train during morning and nocturne period

Trabajo Original: Effect of a mixture of inulin and fructo-oligosaccharide on lactobacillus and bifidobacterium intestinal microbiota of patients receiving radiotherapy; a randomised, double-blind, placebo-controlled trial

Revisión: Effectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials

Trabajo Original: Addition of dietary fiber sources to shakes reduces postprandial glycemia and alters food intake

Revisión: Mechanisms used by inulin-type fructans to improve the lipid profile

Revisión: Indicaciones de diferentes tipos de fibra en distintas patologías

Trabajo Original: Protein intake, nitrogen balance and nutritional status in patients with Parkinson’s disease; time for a change?

Trabajo Original: Enfermedades neurodegenerativas; aspectos nutricionales

Trabajo Original: Hábitos alimentarios y factores sociodemográficos de pacientes con enfermedad de Parkinson en zonas rurales

Trabajo Original: Validation and comparison of EQ-5D-3L and SF-6D instruments in a Spanish Parkinson´s disease population sample

Trabajo Original: The association between dietary fiber and infertility among US Women: The National Health and Nutrition Examination Survey, 2013-2018

Trabajo Original: Low-protein diet supplemented with inulin lowers protein-bound toxin levels in patients with stage 3b-5 chronic kidney disease: a randomized controlled study

Artículo Especial: Componentes bioactivos del grano integral y su efecto en la salud

Trabajo Original: Effects of a functional yogurt enriched with soluble dietary fiber or vegetable proteins on appetite profile. An acute randomized controlled clinical trial

Artículos más populares

Artículo Especial: VII Lección Jesús Culebras. Respuesta inflamatoria sistémica y disfunción/ fracaso multiorgánico tras una agresión: implicaciones metabólicas

Artículo Especial: VIII Lección Jesús Culebras. Medicina intensiva, nutrición e hiperglucemia: una relación muy estrecha

Trabajo Original: Waist-to-height ratio and its relation with cardiometabolic risk factors in children from Bucaramanga, Colombia