Nutrición Hospitalaria 03087 / http://dx.doi.org/10.20960/nh.03087
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Trabajo Original

ABCA1 gene R1587K polymorphism could be associated with metabolic syndrome and increased plasma triglyceride concentration in adults from northern Mexico


Mildren Porchas Quijada, Zyanya Reyes Castillo, Oney Román Pellegrini, Elizabeth Artalejo Ochoa, Silvia Yolanda Moya Camarena, Maricela Montalvo Corral, Martha Nydia Ballesteros Vásquez

Prepublicado: 2020-07-20
Publicado: 2020-10-13

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Objectives: to investigate the relationship of R1587K genotypes with cardiovascular (CV) risk, metabolic syndrome (MetS), lipid profile, paraoxonase-1 (PON1) activity, and anti-oxLDL titers. Methods: we performed a cross-sectional study in 57 northern Mexican adults with no reported diseases. The ABCA1 R1587K SNP was detected by real-time polymerase chain reaction (qPCR) using TaqMan allelic discrimination probes. We evaluated the relationship of R1587K with metabolic syndrome and clinical parameters including lipid profile, glucose and insulin, PON1 activity and concentration, anti-oxLDL antibodies, anthropometry and body-composition parameters, and the atherogenic index of plasma calculation. Results: our results show higher triglyceride levels in the RK + KK carriers as compared to RR carriers (p = 0.031). An association between the RK + KK genotype and the presence of MetS (OR = 4.566, 95% CI = 1.386-14.92, p = 0.010) and a tendency towards high CV risk (OR = 3.317, 95% CI = 0.910-8.611, p = 0.069) was observed in comparison to RR carriers; however, there were no differences in HDL-C levels, PON1 activity and concentration, and anti-oxLDL titers among the R1587K genotypes. Conclusions: in the northern Mexican population, the ABCA1 gene R1587K SNP is present and the RK + KK genotypes are associated with MetS and increased triglyceride concentrations; therefore, it could be a CV risk biomarker. Nevertheless there is a need for further confirmation in longitudinal studies.

Palabras Clave: rs2230808 polymorphism. Cardiovascular diseases. Paraoxonase-1. anti-oxLDL antibodies. Hypertriglyceridemia.



Okada K, Hibi K, Gohbara M, Kataoka S, Takano K, Akiyama E, et al. Association between blood glucose variability and coronary plaque instability in patients with acute coronary syndromes. Cardiovasc Diabetol [Internet] 2015 [Accessed on September 19, 2019];14(1). Available at: http://www.cardiab.com/content/14/1/111
DOI: 10.1186/s12933-015-0275-3
Henriksen T, Mahoney EM, Steinberg D. Enhanced macrophage degradation of biologically modified low density lipoprotein. Arterioscler Dallas Tex 1983;3(2):149-59.
DOI: 10.1161/01.ATV.3.2.149
Palinski W, Rosenfeld ME, Ylä-Herttuala S, Gurtner GC, Socher SS, Butler SW, et al. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci USA 1989;86(4):1372-6.
DOI: 10.1073/pnas.86.4.1372
Fukumoto M, Shoji T, Emoto M, Kawagishi T, Okuno Y, Nishizawa Y. Antibodies against oxidized LDL and carotid artery intima-media thickness in a healthy population. Arterioscler Thromb Vasc Biol 2000;20(3):703-7.
DOI: 10.1161/01.ATV.20.3.703
Tinahones FJ, Gómez-Zumaquero JM, Garrido-Sánchez L, García-Fuentes E, Rojo-Martínez G, Esteva I, et al. Influence of age and sex on levels of anti-oxidized LDL antibodies and anti-LDL immune complexes in the general population. J Lipid Res 2005;46(3):452-7.
DOI: 10.1194/jlr.M400290-JLR200
Masztalewicz M, Nowacki P, Kotlęga D, Bajer-Czajkowska A, Drechsler H. Anti-oxLDL antibodies are clinically insignificant for stroke patients. Neurol Res 2014;36(1):86-91.
DOI: 10.1179/1743132813Y.0000000268
Mackness MI, Hallam SD, Peard T, Warner S, Walker CH. The separation of sheep and human serum «A»-esterase activity into the lipoprotein fraction by ultracentrifugation. Comp Biochem Physiol B 1985;82(4):675-7.
DOI: 10.1016/0305-0491(85)90506-1
Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parmo SL, La Du BN. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Invest 1998;101(8):1581-90.
DOI: 10.1172/JCI1649
Kingwell BA, Chapman MJ, Kontush A, Miller NE. HDL-targeted therapies: progress, failures and future. Nat Rev Drug Discov 2014;13(6):445-64.
DOI: 10.1038/nrd4279
Ikhlef S, Berrougui H, Kamtchueng Simo O, Khalil A. Paraoxonase 1-treated oxLDL promotes cholesterol efflux from macrophages by stimulating the PPARγ-LXRα-ABCA1 pathway. FEBS Lett 2016;590(11):1614-29.
DOI: 10.1002/1873-3468.12198
Oram JF. HDL Apolipoproteins and ABCA1: Partners in the Removal of Excess Cellular Cholesterol. Arterioscler Thromb Vasc Biol 2003;23(5):720-7.
DOI: 10.1161/01.ATV.0000054662.44688.9A
Lu Z, Luo Z, Jia A, Yu L, Muhammad I, Zeng W, et al. Associations of the ABCA1 gene polymorphisms with plasma lipid levels: A meta-analysis. Medicine (Baltimore) 2018;97(50):e13521.
DOI: 10.1097/MD.0000000000013521
Kolovou V, Marvaki A, Boutsikou M, Vasilopoulos G, Degiannis D, Marvaki C, et al. Effect of ATP-binding Cassette Transporter A1 (ABCA1) Gene Polymorphisms on Plasma Lipid Variables and Common Demographic Parameters in Greek Nurses. Open Cardiovasc Med J 2016;10(1):233-9.
DOI: 10.2174/1874192401610010233
Mendoza-Herrera K, Pedroza-Tobías A, Hernández-Alcaraz C, Ávila-Burgos L, Aguilar-Salinas CA, Barquera S. Attributable Burden and Expenditure of Cardiovascular Diseases and Associated Risk Factors in Mexico and other Selected Mega-Countries. Int J Environ Res Public Health 2019;16(20):4041.
DOI: 10.3390/ijerph16204041
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18(6):499-502.
DOI: 10.1093/clinchem/18.6.499
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28(7):412-9.
DOI: 10.1007/BF00280883
Sambrook J, Russell DW. Molecular cloning: a laboratory manual. 3rd ed. Cold Spring Harbor, N.Y: Cold Spring Harbor Laboratory Press; 2001. 3 p.
Haggarty P, Valencia ME, McNeill G, Gonzales NL, Moya SY, Pinelli A, et al. Energy expenditure during heavy work and its interaction with body weight. Br J Nutr 1997;77(03):359.
DOI: 10.1079/BJN19970038
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112(17):2735-52.
DOI: 10.1161/CIRCULATIONAHA.105.169404
Frohlich J, Dobiásová M. Fractional esterification rate of cholesterol and ratio of triglycerides to HDL-cholesterol are powerful predictors of positive findings on coronary angiography. Clin Chem 2003;49(11):1873-80.
DOI: 10.1373/clinchem.2003.022558
Food and Agriculture Organization/World Health Organization/United Nations University. Human energy requeriments. Report of a Joint FAO/WHO/UNU Expert Consultation. Rome; 2001. 96 p.
National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106(25):3143-421.
DOI: 10.1161/circ.106.25.3143
Książek J, Ciechanowicz A, Wierzbicka A, Syczewska M, Grenda R. Is dyslipidemia sustained during remission of nephrotic syndrome genetically determined? Evaluation of genetic polymorphisms of proteins involved in lipoprotein metabolism in children and adolescents with nephrotic syndrome. Pol Arch Intern Med 2009;119(1-2):11-7.
DOI: 10.20452/pamw.592
Clee SM, Zwinderman AH, Engert JC, Zwarts KY, Molhuizen HOF, Roomp K, et al. Common Genetic Variation in ABCA1 Is Associated With Altered Lipoprotein Levels and a Modified Risk for Coronary Artery Disease. Circulation 2001;103(9):1198-205.
DOI: 10.1161/01.CIR.103.9.1198
Frikke-Schmidt R, Nordestgaard BG, Jensen GB, Steffensen R, Tybjærg-Hansen A. Genetic Variation in ABCA1 Predicts Ischemic Heart Disease in the General Population. Arterioscler Thromb Vasc Biol 2008;28(1):180-6.
DOI: 10.1161/ATVBAHA.107.153858
Kolovou V, Kolovou G, Marvaki A, Karakosta A, Vasilopoulos G, Kalogiani A, et al. ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses. Lipids Health Dis 2011;10(1):56.
DOI: 10.1186/1476-511X-10-56
Jensen MK, Pai JK, Mukamal KJ, Overvad K, Rimm EB. Common genetic variation in the ATP-binding cassette transporter A1, plasma lipids, and risk of coronary heart disease. Atherosclerosis 2007;195(1):e172-80.
DOI: 10.1016/j.atherosclerosis.2007.01.025
Rye K-A, Clay MA, Barter PJ. Remodelling of high density lipoproteins by plasma factors. Atherosclerosis 1999;145(2):227-38.
DOI: 10.1016/S0021-9150(99)00150-1
Lamarche B, Uffelman KD, Carpentier A, Cohn JS, Steiner G, Barrett PH, et al. Triglyceride enrichment of HDL enhances in vivo metabolic clearance of HDL apo A-I in healthy men. J Clin Invest 1999;103(8):1191-9.
DOI: 10.1172/JCI5286
Li Z, Deng ML, Tseng C-H, Heber D. Hypertriglyceridemia Is a Practical Biomarker of Metabolic Syndrome in Individuals with Abdominal Obesity. Metab Syndr Relat Disord 2013;11(2):87-91.
DOI: 10.1089/met.2012.0090
Rosenson RS, Davidson MH, Hirsh BJ, Kathiresan S, Gaudet D. Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease. J Am Coll Cardiol 2014;64(23):2525-40
DOI: 10.1016/j.jacc.2014.09.042

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