Nutrición Hospitalaria 03087 / http://dx.doi.org/10.20960/nh.03087

Trabajo Original

ABCA1 gene R1587K polymorphism could be associated with metabolic syndrome and increased plasma triglyceride concentration in adults from northern Mexico

Mildren Porchas Quijada, Zyanya Reyes Castillo, Oney Román Pellegrini, Elizabeth Artalejo Ochoa, Silvia Yolanda Moya Camarena, Maricela Montalvo Corral, Martha Nydia Ballesteros Vásquez

Prepublicado: 2020-07-20

Publicado: 2020-10-13

VOLUMEN 37, NÚM. 5, septiembre-octubre (2020), PAG. 944-950

Logo Descargas Número de descargas: 29166 Logo Visitas Número de visitas: 5091 Citas Citas: 0

Compártelo:

Objectives: to investigate the relationship of R1587K genotypes with cardiovascular (CV) risk, metabolic syndrome (MetS), lipid profile, paraoxonase-1 (PON1) activity, and anti-oxLDL titers. Methods: we performed a cross-sectional study in 57 northern Mexican adults with no reported diseases. The ABCA1 R1587K SNP was detected by real-time polymerase chain reaction (qPCR) using TaqMan allelic discrimination probes. We evaluated the relationship of R1587K with metabolic syndrome and clinical parameters including lipid profile, glucose and insulin, PON1 activity and concentration, anti-oxLDL antibodies, anthropometry and body-composition parameters, and the atherogenic index of plasma calculation. Results: our results show higher triglyceride levels in the RK + KK carriers as compared to RR carriers (p = 0.031). An association between the RK + KK genotype and the presence of MetS (OR = 4.566, 95% CI = 1.386-14.92, p = 0.010) and a tendency towards high CV risk (OR = 3.317, 95% CI = 0.910-8.611, p = 0.069) was observed in comparison to RR carriers; however, there were no differences in HDL-C levels, PON1 activity and concentration, and anti-oxLDL titers among the R1587K genotypes. Conclusions: in the northern Mexican population, the ABCA1 gene R1587K SNP is present and the RK + KK genotypes are associated with MetS and increased triglyceride concentrations; therefore, it could be a CV risk biomarker. Nevertheless there is a need for further confirmation in longitudinal studies.

Palabras Clave: rs2230808 polymorphism. Cardiovascular diseases. Paraoxonase-1. anti-oxLDL antibodies. Hypertriglyceridemia.

Descargar PDF (ENGLISH)

Bibliografía
Artículos Relacionados

Okada K, Hibi K, Gohbara M, Kataoka S, Takano K, Akiyama E, et al. Association between blood glucose variability and coronary plaque instability in patients with acute coronary syndromes. Cardiovasc Diabetol [Internet] 2015 [Accessed on September 19, 2019];14(1). Available at: http://www.cardiab.com/content/14/1/111
DOI: 10.1186/s12933-015-0275-3

Henriksen T, Mahoney EM, Steinberg D. Enhanced macrophage degradation of biologically modified low density lipoprotein. Arterioscler Dallas Tex 1983;3(2):149-59.
DOI: 10.1161/01.ATV.3.2.149

Palinski W, Rosenfeld ME, Ylä-Herttuala S, Gurtner GC, Socher SS, Butler SW, et al. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci USA 1989;86(4):1372-6.
DOI: 10.1073/pnas.86.4.1372

Fukumoto M, Shoji T, Emoto M, Kawagishi T, Okuno Y, Nishizawa Y. Antibodies against oxidized LDL and carotid artery intima-media thickness in a healthy population. Arterioscler Thromb Vasc Biol 2000;20(3):703-7.
DOI: 10.1161/01.ATV.20.3.703

Tinahones FJ, Gómez-Zumaquero JM, Garrido-Sánchez L, García-Fuentes E, Rojo-Martínez G, Esteva I, et al. Influence of age and sex on levels of anti-oxidized LDL antibodies and anti-LDL immune complexes in the general population. J Lipid Res 2005;46(3):452-7.
DOI: 10.1194/jlr.M400290-JLR200

Masztalewicz M, Nowacki P, Kotlęga D, Bajer-Czajkowska A, Drechsler H. Anti-oxLDL antibodies are clinically insignificant for stroke patients. Neurol Res 2014;36(1):86-91.
DOI: 10.1179/1743132813Y.0000000268

Mackness MI, Hallam SD, Peard T, Warner S, Walker CH. The separation of sheep and human serum «A»-esterase activity into the lipoprotein fraction by ultracentrifugation. Comp Biochem Physiol B 1985;82(4):675-7.
DOI: 10.1016/0305-0491(85)90506-1

Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parmo SL, La Du BN. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Invest 1998;101(8):1581-90.
DOI: 10.1172/JCI1649

Kingwell BA, Chapman MJ, Kontush A, Miller NE. HDL-targeted therapies: progress, failures and future. Nat Rev Drug Discov 2014;13(6):445-64.
DOI: 10.1038/nrd4279

Ikhlef S, Berrougui H, Kamtchueng Simo O, Khalil A. Paraoxonase 1-treated oxLDL promotes cholesterol efflux from macrophages by stimulating the PPARγ-LXRα-ABCA1 pathway. FEBS Lett 2016;590(11):1614-29.
DOI: 10.1002/1873-3468.12198

Oram JF. HDL Apolipoproteins and ABCA1: Partners in the Removal of Excess Cellular Cholesterol. Arterioscler Thromb Vasc Biol 2003;23(5):720-7.
DOI: 10.1161/01.ATV.0000054662.44688.9A

Lu Z, Luo Z, Jia A, Yu L, Muhammad I, Zeng W, et al. Associations of the ABCA1 gene polymorphisms with plasma lipid levels: A meta-analysis. Medicine (Baltimore) 2018;97(50):e13521.
DOI: 10.1097/MD.0000000000013521

Kolovou V, Marvaki A, Boutsikou M, Vasilopoulos G, Degiannis D, Marvaki C, et al. Effect of ATP-binding Cassette Transporter A1 (ABCA1) Gene Polymorphisms on Plasma Lipid Variables and Common Demographic Parameters in Greek Nurses. Open Cardiovasc Med J 2016;10(1):233-9.
DOI: 10.2174/1874192401610010233

Mendoza-Herrera K, Pedroza-Tobías A, Hernández-Alcaraz C, Ávila-Burgos L, Aguilar-Salinas CA, Barquera S. Attributable Burden and Expenditure of Cardiovascular Diseases and Associated Risk Factors in Mexico and other Selected Mega-Countries. Int J Environ Res Public Health 2019;16(20):4041.
DOI: 10.3390/ijerph16204041

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18(6):499-502.
DOI: 10.1093/clinchem/18.6.499

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28(7):412-9.
DOI: 10.1007/BF00280883

Sambrook J, Russell DW. Molecular cloning: a laboratory manual. 3rd ed. Cold Spring Harbor, N.Y: Cold Spring Harbor Laboratory Press; 2001. 3 p.

Haggarty P, Valencia ME, McNeill G, Gonzales NL, Moya SY, Pinelli A, et al. Energy expenditure during heavy work and its interaction with body weight. Br J Nutr 1997;77(03):359.
DOI: 10.1079/BJN19970038

Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112(17):2735-52.
DOI: 10.1161/CIRCULATIONAHA.105.169404

Frohlich J, Dobiásová M. Fractional esterification rate of cholesterol and ratio of triglycerides to HDL-cholesterol are powerful predictors of positive findings on coronary angiography. Clin Chem 2003;49(11):1873-80.
DOI: 10.1373/clinchem.2003.022558

Food and Agriculture Organization/World Health Organization/United Nations University. Human energy requeriments. Report of a Joint FAO/WHO/UNU Expert Consultation. Rome; 2001. 96 p.

National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106(25):3143-421.
DOI: 10.1161/circ.106.25.3143

Książek J, Ciechanowicz A, Wierzbicka A, Syczewska M, Grenda R. Is dyslipidemia sustained during remission of nephrotic syndrome genetically determined? Evaluation of genetic polymorphisms of proteins involved in lipoprotein metabolism in children and adolescents with nephrotic syndrome. Pol Arch Intern Med 2009;119(1-2):11-7.
DOI: 10.20452/pamw.592

Clee SM, Zwinderman AH, Engert JC, Zwarts KY, Molhuizen HOF, Roomp K, et al. Common Genetic Variation in ABCA1 Is Associated With Altered Lipoprotein Levels and a Modified Risk for Coronary Artery Disease. Circulation 2001;103(9):1198-205.
DOI: 10.1161/01.CIR.103.9.1198

Frikke-Schmidt R, Nordestgaard BG, Jensen GB, Steffensen R, Tybjærg-Hansen A. Genetic Variation in ABCA1 Predicts Ischemic Heart Disease in the General Population. Arterioscler Thromb Vasc Biol 2008;28(1):180-6.
DOI: 10.1161/ATVBAHA.107.153858

Kolovou V, Kolovou G, Marvaki A, Karakosta A, Vasilopoulos G, Kalogiani A, et al. ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses. Lipids Health Dis 2011;10(1):56.
DOI: 10.1186/1476-511X-10-56

Jensen MK, Pai JK, Mukamal KJ, Overvad K, Rimm EB. Common genetic variation in the ATP-binding cassette transporter A1, plasma lipids, and risk of coronary heart disease. Atherosclerosis 2007;195(1):e172-80.
DOI: 10.1016/j.atherosclerosis.2007.01.025

Rye K-A, Clay MA, Barter PJ. Remodelling of high density lipoproteins by plasma factors. Atherosclerosis 1999;145(2):227-38.
DOI: 10.1016/S0021-9150(99)00150-1

Lamarche B, Uffelman KD, Carpentier A, Cohn JS, Steiner G, Barrett PH, et al. Triglyceride enrichment of HDL enhances in vivo metabolic clearance of HDL apo A-I in healthy men. J Clin Invest 1999;103(8):1191-9.
DOI: 10.1172/JCI5286

Li Z, Deng ML, Tseng C-H, Heber D. Hypertriglyceridemia Is a Practical Biomarker of Metabolic Syndrome in Individuals with Abdominal Obesity. Metab Syndr Relat Disord 2013;11(2):87-91.
DOI: 10.1089/met.2012.0090

Rosenson RS, Davidson MH, Hirsh BJ, Kathiresan S, Gaudet D. Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease. J Am Coll Cardiol 2014;64(23):2525-40
DOI: 10.1016/j.jacc.2014.09.042

Artículos más populares

Revisión: Bebidas de soja y salud femenina. Revisión de la evidencia y opinión de expertos

Las bebidas vegetales de soja constituyen una alte...

Publicado: 2022-07-25

Resumen | PDF

Trabajo Original: Experience with the management of patients requiring home enteral nutrition in routine clinical practice in Spain: the ECONES study

Introduction: enteral nutrition is an effective me...

Publicado: 2023-02-09

Resumen | PDF

Revisión: La dieta como fuente de sulfuro de hidrógeno y sus efectos en la salud y la enfermedad

Conocido originalmente por sus efectos deletéreos...

Publicado: 2022-09-28

Resumen | PDF

Licencia creative commons: Open Access bajo la licencia Creative Commons 4.0 CC BY-NC-SA
https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode

Editado en Madrid por:

Diseño y Desarrollo web Im3diA comunicación

Trabajo Original

ABCA1 gene R1587K polymorphism could be associated with metabolic syndrome and increased plasma triglyceride concentration in adults from northern Mexico

Artículos Relacionados:

Trabajo Original: Estudio del impacto del índice de masa corporal pretrasplante sobre el pronto funcionamiento del injerto renal

Trabajo Original: Factores predictores de hipertrigliceridemia en pacientes hospitalizados con nutrición parenteral total

Trabajo Original: Factores asociados al desarrollo de diabetes mellitus tipo 2 en chile

Nota Clínica: Déficit de glicerol kinasa en el adulto: hipertrigliceridemia resistente a tratamiento dietético y farmacológico

Trabajo Original: Consumption of avocado oil (Persea americana) improves the biochemical profile of rats submitted to long-term androgenic stimulation

Trabajo Original: Correlation between serum content of the main COPs (cholesterol oxidation products) from autoxidation and cardiovascular risk factors

Trabajo Original: Association of uricemia with biochemical and dietary factors in human adults with metabolic syndrome genotyped to C677T polymorphism in the methylenetetrahydrofolate reductase gene

Revisión: Impact of different protein sources in the glycemic and insulinemic responses

Trabajo Original: Complicaciones asociadas a la nutrición parenteral en los enfermos con infección por SARS-CoV-2

Revisión: Ácidos grasos trans: un análisis del efecto de su consumo en la salud humana, regulación del contenido en alimentos y alternativas para disminuirlos

Revisión: Papel de los ácidos grasos omega-3 en la prevención de enfermedades cardiovasculares

Trabajo Original: Análisis del perfil lipídico de dos especies de merluza “Merluccius capensis y Merluccius paradoxus” y su aportación a la prevención de enfermedades cardiovasculares

Trabajo Original: Ingesta de huevo y factores de riesgo cardiovascular en adolescentes; papel de la actividad física. Estudio HELENA

Trabajo Original: Low-fat dairy products consumption is associated with lower triglyceride concentrations in a Spanish hypertriglyceridemic cohort

Trabajo Original: Study on the mortality in Ecuador related to dietary factors

Trabajo Original: Hypertriglyceridemic waist phenotype: association with metabolic disorders and visceral fat in adults

Revisión: Glycemic index role on visceral obesity, subclinical inflammation and associated chronic diseases

Revisión: Aldosterone: a cardiometabolic risk hormone?

Revisión: Safety in the hypertriglyceridemia treatment with n-3 polyunsaturated fatty acids on glucose metabolism in subjects with type 2 diabetes mellitus

Trabajo Original: Fructose intake: is there an association with uric acid levels in nondialysis-dependent chronic kidney disease patients?

Revisión: Inflammatory markers in relation to body composition, physical activity and assessment of nutritional status of the adolescents

Revisión: Hepatic inflammatory biomarkers and its link with obesity and chronic diseases

Trabajo Original: Consumo de queso y lácteos y enfermedades crónicas asociadas a obesidad, ¿amigo o enemigo?

Trabajo Original: Hypertriglyceridemic waist phenotype and cardiometabolic alterations in Brazilian adults

Nota Clínica: Nutrición parenteral total en una paciente gestante con pancreatitis aguda e hipertrigliceridemia por déficit de lipoproteín lipasa

Revisión: Effect of chia seed (Salvia hispanica L.) consumption on cardiovascular risk factors in humans: a systematic review

Trabajo Original: Neck circumference as a predictor of cardiometabolic risk and truncal obesity in people living with HIV

Carta Editor: Knowledge of the recommendations for the diagnosis and treatment of childhood obesity among a group of medical students in Mexico

Artículos más populares

Revisión: Bebidas de soja y salud femenina. Revisión de la evidencia y opinión de expertos

Trabajo Original: Experience with the management of patients requiring home enteral nutrition in routine clinical practice in Spain: the ECONES study

Revisión: La dieta como fuente de sulfuro de hidrógeno y sus efectos en la salud y la enfermedad