Trabajo Original
Food intake influences the incidence of cardiovascular disease by driving cardiac remodeling — Evidence from a Mendelian randomization
Bingfu Wang, Yulong Song, Yujian Fan, Zhiqiang Zhao
Número de descargas:
10
Número de visitas:
20
Citas:
0
Compártelo:
Background: research on dietary habits and cardiovascular diseases shows inconsistent results. Diets on cardiovascular diseases are primarily mediated by cardiac structure, but specific pathways remain unclear. Material and methods: we conducted a Mendelian randomization study and identified twelve types of food were related to coronary artery disease, 17 to heart failure, and 16 to dilated cardiomyopathy; 13 were associated with atrial fibrillation. We then identified cardiac structure closely related to the four cardiovascular diseases and conducted mediation analysis. Results: increased consumption of grains, dried fruits, and cheese may tentatively reduce coronary heart disease risk through distinct biomechanical pathways—including reduced segmental longitudinal strain (grains, 18.7 %), decreased left ventricular stroke volume with narrowed ascending aortic area (dried fruits; mediation through 28.9 % and 18.5 % pathways), and attenuated myocardial wall thickness (cheese, 4.25 %)—while elevated alcohol intake might heighten risk via increased stroke volume (18.6 %), amplified segmental strain (8.6 %), and elevated cardiac workload. Exploratory analyses suggest coffee-associated heart failure risk could involve mediation by segmental/global circumferential strain (mediation through 14.5 % and 27.7 % pathways) and left ventricular volume (through 23.1 %, and 22.5 % pathways), whereas cooked vegetables may partially influence dilated cardiomyopathy risk through increased left ventricular mass (14.9 %) and myocardial wall thickness (20.2 %), potentially exacerbating atrial fibrillation via impaired global longitudinal strain (36.1 %). Observational data tentatively link feta cheese to dilated cardiomyopathy risk through altered left heart volumetric parameters: left atrial minimal volume (30.3 %), ventricular end-diastolic (14.8 %)/systolic volumes (14.8 %). Conclusion: our study provides new insights that dietary adjustments to improve cardiac remodeling may be a potent strategy for the prevention and management of cardiovascular diseases. However, the interpretation of the mediation results requires caution.
Palabras Clave: Food intake. Cardiovascular diseases. Cardiac structure. Mendelian randomization. Mediation analysis.
DOI: 10.1038/s41591-022-01990-1
DOI: 10.1161/CIR.0000000000001247
DOI: 10.20517/jca.2021.40
DOI: 10.1016/S0140-6736(14)60107-0
DOI: 10.1007/s40256-024-00641-9
DOI: 10.1007/s40256-024-00658-0
DOI: 10.3390/nu15234898
DOI: 10.1001/jama.2017.0947
DOI: 10.1101/cshperspect.a041302
DOI: 10.1093/hmg/ddu328
DOI: 10.1016/j.csbj.2022.05.015
DOI: 10.1038/s41467-020-15948-9
DOI: 10.7554/eLife.34408
DOI: 10.1093/bioinformatics/btv402
DOI: 10.1001/jama.2017.17219
DOI: 10.1002/gepi.21758
DOI: 10.1371/journal.pgen.1010166
DOI: 10.1093/bib/bbab019
DOI: 10.1016/j.jclinepi.2014.09.005
DOI: 10.1038/s41588-018-0099-7
DOI: 10.1007/s10654-021-00757-1
DOI: 10.1093/ije/dyr233
DOI: 10.1093/eurheartj/ehu514
DOI: 10.1161/CIRCHEARTFAILURE.114.001787
DOI: 10.1161/CIRCULATIONAHA.117.030387
DOI: 10.1080/09571264.2011.603251
DOI: 10.1093/eurheartj/ehaa953
DOI: 10.1007/s11886-020-01369-z
DOI: 10.1007/s12015-021-10267-y
DOI: 10.3390/ijms17101651
DOI: 10.1007/s00394-016-1292-z
DOI: 10.1111/ijs.12516
DOI: 10.1080/10408398.2021.1954873
DOI: 10.1007/s10654-017-0243-1
DOI: 10.1007/s11357-024-01262-5
DOI: 10.1002/fsn3.3848
DOI: 10.1016/S0140-6736(17)32253-5
DOI: 10.3389/fnut.2022.831470
DOI: 10.3390/nu15071611
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