Nutrición Hospitalaria 03155 / http://dx.doi.org/10.20960/nh.03155
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Trabajo Original

Consumption of avocado oil (Persea americana) improves the biochemical profile of rats submitted to long-term androgenic stimulation


Vivian Alves Pereira Silva, Gilson Teles Boaventura, Renato de Souza Abboud, José Antônio Silva Ribas, Mauricio Alves Chagas

Prepublicado: 2020-09-22
Publicado: 2020-10-13

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Introduction: indiscriminate use of anabolic steroids is associated with cardiovascular diseases, renal damage, and hepatic toxicity. Contrastingly, nutraceutical foods such as avocados prevent and control several diseases, as they can reduce the effects of oxidative stress. Objective: this study evaluates the benefits of consuming an avocado oil-based diet to attenuate the systemic damage caused by supraphysiological doses of testosterone, by analyzing the biochemical profile of 28 42-day-old male Wistar rats. Methods: silicone pellets containing testosterone were surgically implanted, and they received control or avocado oil-based feed. After 20 weeks, all the male rats were anesthetized and their blood samples collected. Results: although the high hormone concentration had a negative influence on the biochemical profile of these animals, the groups that consumed avocado oil exhibited a reduction in serum triacylglycerols (-21 %; p = 0.0001), VLDL (-20 %; p = 0.0085), LDL (-78 %; p < 0.0001), and total cholesterol (-12 %; p < 0.0001), along with positive changes in their HDL concentrations (+7 %; p = 0.001). The avocado oil groups also manifested a reduction in the total concentration of serum proteins (-24 %; p = 0.0357), albumin (-26 %; p = 0.0015), urea (-14 %; p = 0.04), and creatinine (-33 %; p < 0.0001). The concentration of liver transaminases was found to be higher in the animals included in the induced group (ALT, +66 %; p = 0.0005, and AST, +23 %; p = 0.0021), whereas they remained stable in the avocado oil group. Conclusion: from the above, it may be concluded that supraphysiological doses of testosterone are related to increased risk factors for cardiovascular, renal, and hepatic diseases, and that the consumption of avocado oil shields the biochemical profile, thus reducing the associated risk factors.

Palabras Clave: Testosterone. Avocado oil. Cardiovascular diseases. Renal damage. Hepatic toxicity. Biochemical profile.



Cuschieri, Andrea, Camilleri, Emma, Cricchiola, Eleonore, Blundell, Renald (2023) Avocados' effect on hormonal physiology: a comprehensive narrative review. Food Materials Research
da Silva, Vivian Alves Pereira, Abboud, Renato de Souza, Contreiras, Ellen Cortez, Boaventura, Gilson Teles, Chagas, Mauricio Alves (2023) Avocado Oil ( Persea americana ) Reduces Epithelial Proliferation on Benign Prostatic Hyperplasia . Journal of the American Nutrition Association
Lichtenfeld J, Deal BJ, Crawford S. Sudden cardiac arrest following ventricular fibrillation attributed to anabolic steroid use in an adolescent. Cardiology in the Young 2016;26(5):996-8.
DOI: 10.1017/S104795111600007X
Nicholls AR, Cope E, Bailey R, Koenen K, Dumon D, Theodorou NC, et al. Children's First Experience of Taking Anabolic-Androgenic Steroids can Occur before Their 10th Birthday: A Systematic Review Identifying 9 Factors That Predicted Doping among Young People. Front Psychol 2017;8:1015.
DOI: 10.3389/fpsyg.2017.01015
Piacentino D, Kotzalidis GD, Longo L, Pavan A, Stivali L, Stivali G, et al. Body Image and Eating Disorders are Common among Professional and Amateur Athletes Using Performance and Image Enhancing Drugs: A Cross-Sectional Study. J Psychoactive Drugs 2017;49(5):373-84.
DOI: 10.1080/02791072.2017.1359708
dos Santos RL, da Silva FB, Ribeiro RF, Stefanon I. Sex hormones in the cardiovascular system. Hormone molecular biology and clinical investigation 2014;18(2):89-103.
DOI: 10.1515/hmbci-2013-0048
Frati P, Busardò FP, Cipolloni L, De Dominicis E, Fineschi V. Anabolic androgenic steroid (AAS) related deaths: autoptic, histopathological and toxicological findings. Current neuropharmacology 2015;13(1):146-59.
DOI: 10.2174/1570159X13666141210225414
Yeap BB. Sex steroids and cardiovascular disease. Asian journal of andrology 2014;16(2):239.
DOI: 10.4103/1008-682X.122357
Silva VAP, Boaventura GT, Abboud RS, Ribas JAS, Chagas MA. Consumption of Green Tea (Camellia sinensis) Improves Lipid, Hepatic, and Hematological Profiles of Rats That Are Submitted to Long-Term Androgenic Stimulation. American Journal of Sports Science 2018;6(4):7.
Herlitz LC, Markowitz GS, Farris AB, Schwimmer JA, Stokes MB, Kunis C, et al. Development of focal segmental glomerulosclerosis after anabolic steroid abuse. Journal of the American Society of Nephrology 2010;21(1):163-72.
DOI: 10.1681/ASN.2009040450
Luciano RL, Castano E, Moeckel G, Perazella MA. Bile acid nephropathy in a bodybuilder abusing an anabolic androgenic steroid. American Journal of Kidney Diseases 2014;64(3):473-6.
DOI: 10.1053/j.ajkd.2014.05.010
Silva VAP, Boaventura GT, Abboud RS, Ribas JAS, Chagas MA. Green Tea Consumption Lower Damage and Inflammatory Cytokines in Rat Cardiovascular System Under Androgenic Stimulation. American Journal of Sports Science 2019;7(4):141-8.
DOI: 10.11648/j.ajss.20190704.12
Štimac D, Milić S, Dintinjana RD, Kovac D, Ristić S. Androgenic/Anabolic steroid-induced toxic hepatitis. Journal of clinical gastroenterology 2002;35(4):350-2.
DOI: 10.1097/00004836-200210000-00013
Banos G, Pérez-Torres I, El Hafidi M. Medicinal agents in the metabolic syndrome. Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Cardiovascular & Hematological Agents) 2008;6(4): 237-52.
DOI: 10.2174/187152508785909465
Duester KC. Avocado fruit is a rich source of beta-sitosterol. J Am Diet Assoc 2001;101(4):404-5.
DOI: 10.1016/S0002-8223(01)00102-X
De Souza Abboud R, Pereira VA, Soares da Costa CA, Boaventura GT, Chagas MA. The action of avocado oil on the lipidogram of wistar rats submitted to prolonged androgenic stimulum. Nutr Hosp 2015;32(2):696-701.
Loizou S, Lekakis I, Chrousos GP, Mousatsou P. Beta-sitosterol exhibits anti-inflammatory activity in human aortic endothelial cells. Mol Nutr Food Res 2010;54(4):551-8.
DOI: 10.1002/mnfr.200900012
Al-Okbi SY, Mohamed DA, Hamed TE, Esmail RSh, Donya SM. Prevention of renal dysfunction by nutraceuticals prepared from oil rich plant foods. Asian Pac J Trop Biomed 2014;4(8):618-27.
DOI: 10.12980/APJTB.4.201414B66
Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002;8(2):143-52.
DOI: 10.1089/107555302317371433
de Amorim Ribeiro IC, Soares da Costa CA, Pereira da Silva VA, Silva Côrrea LBN, Boaventura GT, Chagas MA. Flaxseed reduces epithelial proliferation but does not affect basal cells in induced benign prostatic hyperplasia in rats. European Journal of Nutrition 2017;56(3):1201-10.
DOI: 10.1007/s00394-016-1169-1
Reeves PG, Nielsen FH, Fahey Jr GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993;123(11):1939-51.
DOI: 10.1093/jn/123.11.1939
Melo MGDd, Dória GAA, Serafini MR, Araújo AAS. Valores de referência hematológicos e bioquímicos de ratos (Rattus novergicus linhagem Wistar) provenientes do biotério central da Universidade Federal de Sergipe. Scientia plena 2012;8(9):6.
Berasategi I, Barriuso B, Ansorena D, Astiasarán I. Stability of avocado oil during heating: Comparative study to olive oil. Food Chem 2012;132(1):439-46.
DOI: 10.1016/j.foodchem.2011.11.018
Sriraman S, Ramanujam GM, Ramasamy MK, Dubey GP. Identification of beta-sitosterol and stigmasterol in Bambusa bambos (L.) Voss leaf extract using HPLC and its estrogenic effect in vitro. J Pharm Biomed Anal 2015;115:55-61.
DOI: 10.1016/j.jpba.2015.06.024
Panahi Y, Beiraghdar F, Kashani N, Javan NB, Dadjo Y. Comparison of piascledine (avocado and soybean oil) and hormone replacement therapy in menopausal-induced hot flashing. Iran J Pharm Res 2011;10(4):941-51.
Venâncio DP, Nobrega ACL, Tufik S, Mello MT. Descriptive assessment on the use of anabolic steroids and their effect on the biochemical and neuroendocrine variables in practitioners of resisted exercise. Revista Brasileira de Medicina do Esporte 2010;16(3):191-5.
DOI: 10.1590/S1517-86922010000300007
Hartgens F, Rietjens G, Keizer HA, Kuipers H, Wolffenbuttel BHR. Effects of androgenic-anabolic steroids on apolipoproteins and lipoprotein (a). British Journal of Sports Medicine 2004;38(3):253-9.
DOI: 10.1136/bjsm.2003.000199
Carvajal-Zarrabal O, Nolasco-Hipolito C, Aguilar-Uscanga MG, Melo-Santiesteban G, Hayward-Jones PM, Barradas-Dermitz DM. Avocado oil supplementation modifies cardiovascular risk profile markers in a rat model of sucrose-induced metabolic changes. Dis Markers 2014;2014:386425.
DOI: 10.1155/2014/386425
Del Toro-Equihua M, Velasco-Rodríguez R, López-Ascencio R, Vásquez C. Effect of an avocado oil-enhanced diet (Persea americana) on sucrose-induced insulin resistance in Wistar rats. J Food Drug Anal 2016;24(2):350-7.
DOI: 10.1016/j.jfda.2015.11.005
Riezzo I, Turillazzi E, Bello S, Cantatore S, Cerretani D, Di Paolo M, et al. Chronic nandrolone administration promotes oxidative stress, induction of pro-inflammatory cytokine and TNF-alpha mediated apoptosis in the kidneys of CD1 treated mice. Toxicol Appl Pharmacol 2014;280(1):97-106.
DOI: 10.1016/j.taap.2014.06.031
Chignalia AZ, Oliveira MA, Debbas V, Dull RO, Laurindo FRM, Touyzet RM, et al. Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms. Clin Sci (Lond) 2015;129(1):39-48.
DOI: 10.1042/CS20140548
Carvajal-Zarrabal O, Nolasco-Hipolito C, Aguilar-Uscanga MG, Melo Santiesteban G, Hayward-Jones PM, Barradas-Dermitz DM. Effect of dietary intake of avocado oil and olive oil on biochemical markers of liver function in sucrose-fed rats. Biomed Res Int 2014;2014:595479.
DOI: 10.1155/2014/595479
Alkhunaizi AM, El Tigani MA, Rabah RS, Nasr SH. Acute bile nephropathy secondary to anabolic steroids. Clin Nephrol 2016;85(2):121-6.
DOI: 10.5414/CN108696
Winnett G, Cranfield L, Almond M. Apparent renal disease due to elevated creatinine levels associated with the use of boldenone. Nephrol Dial Transplant 2011;26(2):744-7.
DOI: 10.1093/ndt/gfq663
Marquez-Ramirez CA, Hernández de la Paz JL, Ortiz-Ávila O, Raya-Farias A, González-Hernández JC, Rodríguez-Orozco AR, et al. Comparative effects of avocado oil and losartan on blood pressure, renal vascular function, and mitochondrial oxidative stress in hypertensive rats. Nutrition 2018;54:60-7.
DOI: 10.1016/j.nut.2018.02.024
Ortiz-Avila O, Sámano-García CA, Calderón-Cortés E, Pérez-Hernández IH, Mejía-Zepeda R, Rodríguez-Orozco AR, et al. Dietary avocado oil supplementation attenuates the alterations induced by type I diabetes and oxidative stress in electron transfer at the complex II-complex III segment of the electron transport chain in rat kidney mitochondria. J Bioenerg Biomembr 2013;45(3):271-87.
DOI: 10.1007/s10863-013-9502-3
Sharmila R, Sindhu G, Arockianathan PM. Nephroprotective effect of beta-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats. J Basic Clin Physiol Pharmacol 2016;27(5):473-82.
DOI: 10.1515/jbcpp-2015-0085
Gupta S, Naini BV, Munoz R, Graham RP, Kipp BR, Torbenson MS, et al. Hepatocellular Neoplasms Arising in Association With Androgen Use. Am J Surg Pathol 2016;40(4):454-61.
DOI: 10.1097/PAS.0000000000000576
Hamouda AF, Sameeh MY, Shrourou RM. Effect of Avocado (Persea americana), Cabbage (Brassica oleracea) and Ginger (Zingiber officinale) on Rat Liver and Thyroid Injuries Induced by CCl4 (Carbon Tetrachloride). Journal of Pharmacy and Pharmacology 2016;4:108-18.
Kesler T, Sandhu RS, Krishnamoorthy S. Hepatology: hepatocellular carcinoma in a young man secondary to androgenic anabolic steroid abuse. J Gastroenterol Hepatol 2014;29(11):1852.
DOI: 10.1111/jgh.12809
Brai BI, Adisa RA, Odetola AA. Hepatoprotective properties of aqueous leaf extract of Persea americana, Mill (Lauraceae) 'avocado' against CCL4-induced damage in rats. Afr J Tradit Complement Altern Med 2014;11(2):237-44.
DOI: 10.4314/ajtcam.v11i2.2

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