Nutrición Hospitalaria 03193 / http://dx.doi.org/10.20960/nh.03193
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Trabajo Original

Interaction between age and vitamin D deficiency in severe COVID-19 infection


Fernando Macaya, Carolina Espejo Paeres, Adrián Valls, Antonio Fernández-Ortiz, Juan González del Castillo, F. Javier Martín-Sánchez, Isabelle Runkle, Miguel Ángel Rubio Herrera

Prepublicado: 2020-09-22
Publicado: 2020-10-13

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Background: coronavirus disease 2019 (COVID-19) can induce an exaggerated inflammatory response. Vitamin D is a key modulator of the immune system. We hypothesized that vitamin D deficiency (VDD) could increase the risk of developing severe COVID-19 infection. Methods: patients with confirmed COVID-19 seen at the emergency department of our hospital with recent measurements of 25(OH)D were recruited. We explored the association of vitamin D deficiency (VDD), defined as 25-hydroxyvitamin D < 20 ng/mL, with a composite of adverse clinical outcomes. Results: we included 80 patients, of which 31 (39 %) presented the endpoint. VDD tended to predict an increased risk of developing severe COVID-19 after adjusting for age, gender, obesity, cardiac disease, and kidney disease [OR 3.2 (95 % CI: 0.9-11.4), p = 0.07]. Age had a negative interaction with the effect of VDD on the composite outcome (p = 0.03), indicating that the effect was more noticeable at younger ages. Furthermore, male gender was associated with VDD and with severe COVID-19 at younger ages. Conclusions: in this retrospective study, vitamin D deficiency showed a signal of association with severe COVID-19 infection. A significant interaction with age was noted, suggesting VDD may have a greater impact in younger patients. These findings should be confirmed in larger, prospective, adequately powered studies.

Palabras Clave: Coronavirus disease 2019. Severe acute respiratory syndrome. Vitamin D deficiency. Angiotensin converting enzyme 2.



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Nelson Hun Gamboa , Massiel Salazar , Sebastián Aliste , Camilo Aguilera , María Elvira Cárdenas

Publicado: 2022-08-01 / http://dx.doi.org/10.20960/nh.04383

Revisión: Vitamina D y polimorfismos de los genes VDR y GC en la severidad y mortalidad por COVID-19. Una revisión sistemática

Giulia Camporesi , Regina Hernández Payró , Tania Levy Esses , María José Peláez Samperio , Adrián Macho González , Francisco J. Sánchez-Muniz

Publicado: 2022-06-23 / http://dx.doi.org/10.20960/nh.04299

Trabajo Original: Risk of vitamin D deficit in asthmatic children hospitalized in the north area of Santiago

María Elena Herrera , Gerardo Weisstaub , Ana María Herrera Gana , Ricardo Pinto

Publicado: 2022-05-21 / http://dx.doi.org/10.20960/nh.04249

Trabajo Original: Evolución de la dieta y la actividad física de los estudiantes universitarios tras la pandemia de COVID-19

Almudena Tárraga Marcos , Julio Antonio Carbayo Herencia , Josefa Maria Panisello Royo , José Francisco López Gil , Loreto Tárraga Marcos , Pedro Juan Tárraga López

Publicado: 2022-09-01 / http://dx.doi.org/10.20960/nh.04420

Trabajo Original: Inequalities in the association between adherence to the Mediterranean diet and physical fitness in the young population during the COVID-19 lockdown

Javier Brazo Sayavera , Inácio Crochemore-Silva , Bruno Bizzozero Peroni , Noelia González-Gálvez , Edina Maria de Camargo , José Francisco López-Gil

Publicado: 2022-05-04 / http://dx.doi.org/10.20960/nh.04225

Revisión: Influencia de la dieta en el riesgo de infección y de gravedad de la COVID-19: una revisión sistemática

Ester Leno-Durán , Marcos Micha Mabale , Marina García-Pérez , Aurora Bueno-Cavanillas , Rocío Barrios-Rodríguez , Pilar Requena

Publicado: 2022-09-20 / http://dx.doi.org/10.20960/nh.04448

Trabajo Original: Feeding intolerance during prolonged prone position in overweight and obese patients with severe COVID-19

Iván Armando Osuna-Padilla , Nadia Carolina Rodríguez-Moguel , Laurie Abril López-Orduña , Ana Lucía Gómez-Rodríguez , Alan García-Grimaldo , Sebastián Rodríguez-Llamazares , Ismael Maldonado-Beltrán , Martín Armando Ríos-Ayala , Carmen Margarita Hernández-Cárdenas

Publicado: 2022-11-28 / http://dx.doi.org/10.20960/nh.04553

Trabajo Original: The CONUT score predicts the length of hospital stay and the risk of long COVID

Zi-Wen Zhao , Qin Chen , Xin-Tao Zhang , Yu-Kun Luo

Publicado: 2023-02-22 / http://dx.doi.org/10.20960/nh.04656

Trabajo Original: Physical activity as a mediator of the association of body mass index change with anxiety/depression symptoms in Brazilian adults during COVID-19

Edina Maria de Camargo , José Francisco López Gil , Cristiane Galvao Costa , Pedro Juan Tárraga López , Wagner de Campos , Sergio Gregorio da Silva

Publicado: 2023-04-02 / http://dx.doi.org/10.20960/nh.04716

Trabajo Original: Lifestyles of 2- to 11-year-old children during the COVID-19 pandemic

Erika Mayorga-Borbolla , Danae Gabriela Valenzuela-Bravo , María del Carmen Morales-Ruán , Ignacio Méndez-Gómez Humarán , Teresa Shamah-Levy

Publicado: 2023-04-15 / http://dx.doi.org/10.20960/nh.04738

Trabajo Original: It is not just about prescription. A cohort study of the impact of enteral nutrition on mortality of hospitalized patients with COVID-19

Adriana Flores-López , Gabriela Quiroz-Olguin , Alejandro Gabriel González-Garay , Aurora E. Serralde-Zúñiga

Publicado: 2023-06-22 / http://dx.doi.org/10.20960/nh.04828

Trabajo Original: Health habits during lockdown for COVID-19 in Spain and its effect on weight

José I. Baile , María J. González-Calderón , MARIA FRENZI RABITO ALCON , Eva Izquierdo Sotorrío

Publicado: 2023-04-18 / http://dx.doi.org/10.20960/nh.04740

Trabajo Original: Desarrollo y validación de la puntuación de calidad alimentaria en el ELSA-Brasil

Carla Moronari de Oliveira Aprelini , Jordana Herzog Siqueira , Haysla Xavier Martins , Taísa Sabrina Silva Pereira , Yazareni José Mercadante Urquía , Maria del Carmen Bisi Molina

Publicado: 2023-01-10 / http://dx.doi.org/10.20960/nh.04598

Trabajo Original: Nutritional status and its relationship with COVID-19 prognosis in hemodialysis patients

Paz Andrea Bersano-Reyes , Gema Nieto , Alicia Cana-Poyatos , Paula Guerrero Sanz , Rafa García-Maset , Alicia García-Testal

Publicado: 2023-07-07 / http://dx.doi.org/10.20960/nh.04850

Carta Editor: Impacto de la nutrición enteral en la mortalidad de pacientes hospitalizados con COVID-19

Mónica Zúñiga González

Publicado: 2024-04-05 / http://dx.doi.org/10.20960/nh.05256

Trabajo Original: Evaluation of depression, anxiety, risky eating behaviors, eating habits and physical activity after the COVID-19 pandemic among adolescents in Mexico City

Diva Guadalupe Sotomayor Terán , Irina Lazarevich , Rey Gutiérrez Tolentino , Gerardo Leija Alva , Jorge Armando Barriguete Meléndez , Claudia Cecilia Radilla Vázquez

Publicado: 2023-12-12 / http://dx.doi.org/10.20960/nh.05083

Carta Editor: Nutritional status, COVID-19 prognosis and hemodialysis patients

Hinpetch Daungsupawong , Viroj Wiwanitkit

Publicado: 2024-04-27 / http://dx.doi.org/10.20960/nh.05287

Trabajo Original: Effects of COVID-19 lockdown on children´s sleep quality, physical activity, screen time, and diet

Roberto López-Iracheta , Nerea Martín Calvo , Laura Moreno-Galarraga , José Manuel Moreno Villares

Publicado: 2023-11-26 / http://dx.doi.org/10.20960/nh.05051

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