Nutrición Hospitalaria 05747 / http://dx.doi.org/10.20960/nh.05747

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Effects of immunonutrition on serum albumin, IL-6, and TNF-α levels in patients with COVID-19: a randomized controlled double-blind clinical trial

Letícia Costa Lopes, Rodrigo Merces Weyll Pimentel, Arthur Pinto Silva, Amália Ivine Costa Santana, Durval Ribas Filho, Argemiro D’Oliveira Júnior, Dandara Almeida Reis da Silva, Vitória Cesar Santos Gonçalves Brito, André Silva dos Santos, Sandra Lúcia Fernandes, Isolda Padro de Negreiros Nogueira Maduro, Julita Maria Freitas Coelho, André Luiz Costa Brandão, Marcella Garcez Duarte, Antônio Marcos Tosoli Gomes, Lorena de Carvalho Almeida, Simone Maria de Oliveira Silva, Marcia Cristina Almeida Magalhães, Tatiana dos Santos Moreira, Nádia Juliana Beraldo Goulart Borges Haubert, Sérgio Queiroz Braga, Caroline da Silva Barbosa, Aritana Alves Pereira, Rejane Macedo de Sousa, Danila Aglae Marques Cabral, Murilo Silva Oliveira, Eline de Almeida Soriano, Kairo Silvestre Meneses Damasceno, Magno Conceição das Merces

Prepublicado: 2025-07-07

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Background and objectives: many specialized immunonutrient formulas are available, with an emphasis on combining arginine, omega 3 fatty acids, and nucleotides. These nutrients can reduce the inflammatory pattern, with an increased contribution to resolving infections. Considering the inflammatory catharsis resulting from COVID-19, this study aimed to evaluate the effect of immunonutrition on serum albumin, IL-6, and TNF-α levels in patients with COVID-19. Materials and methods: a randomized double-blind clinical trial conducted in 2020 in Salvador, Bahia, Brazil. Adult patients diagnosed with COVID-19 were randomized to receive a standard hyperproteic normocaloric supplement (control) or a supplement enriched with immunonutrients (experiment) for a period of 07 days. The participants were monitored for a period of 08 days, including the assessment of risk and nutritional status, and collection of blood samples to evaluate albumin, IL-6, and TNF-α. Results: 70 patients were included in the study. 64 were randomly allocated to receive an immunonutrient diet or a standard control diet. The nutritional diagnosis was 27.6 (± 0.8) kg/m² and the nutritional risk was 41.9 %. In the experiment group, there was an average increase in albumin to 0.84 (± 0.65) mg/dL, while in the control group this increase was of 0.21 (± 0.52) mg/dL. Regarding the IL-6 doses, there was a reduction both in the experiment group (-257.27 ± 448.89 pg/ml) and in the control group (-142.75 ± 253.29 pg/ml). When comparing the difference in TNF-α levels, a reduction was observed in the experiment group (-3.72 ± 5.98 pg/ml), while an increase in the control group (5.33 ± 10.48 pg/ml) was observed. Conclusions: the use of an oral supplement enriched with immunonutrients seems to be able to reduce the IL-6 and TNF-α serum levels and increase serum albumin levels.

Palabras Clave: Immunonutrition. Albumin. IL-6. TNF-α. COVID-19.

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Publicado: 2022-01-19 / http://dx.doi.org/

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Trabajo Original: Asociación de albúmina sérica y valoración global subjetiva en pacientes incidentes en diálisis peritoneal

Publicado: 2022-01-24 / http://dx.doi.org/

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Trabajo Original: Cambios en el comportamiento alimentario de personas adultas con elevado nivel académico durante las diferentes etapas del confinamiento domiciliario por COVID-19 en Iberoamérica

Luisa Muñoz Salvador , Mercedes Briones Urbano , Yago Pérez

Publicado: 2021-12-28 / http://dx.doi.org/10.20960/nh.04018

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Carta Editor: Estado nutricional y niveles de ansiedad durante la pandemia de COVID-19

Héctor Fuentes-Barria , Raúl Aguilera-Eguía , Luis Soto Jara , Catalina González Wong

Publicado: 2022-02-17 / http://dx.doi.org/10.20960/nh.04086

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Nota Clínica: Beau’s line in COVID-19 after a long ICU stay

Jessica Alves de Paula , Claudio Luciano Franck , Sandra Regina Justino , Luíza Silva Leite , Odery Ramos Junior , Estela Iraci Rabito

Publicado: 2022-03-24 / http://dx.doi.org/10.20960/nh.04131

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Carta Editor: Results of lifestyle during confinement COVID-19 in schoolchildren aged 8 to 12 years

Luis Alberto Flores Olivares , Liliana Aracely Enriquez-del Castillo , Leslie Michelle González Cano , Estefania Quintana Mendias , Natanael Cervantes Hernández

Publicado: 2022-06-06 / http://dx.doi.org/10.20960/nh.04272

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Carta Editor: La necesidad de un programa multidimensional para pacientes con obesidad, como medida preventiva ante una nueva ola de Covid-19 en Chile

Michel Alberto Garat Escudero , Ángel Roco-Videla

Publicado: 2022-06-09 / http://dx.doi.org/10.20960/nh.04280

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Carta Editor: Salud mental en niños y adolescentes como factor agravante en la pandemia del Covid-19

Michel Alberto Garat Escudero , Ángel Roco-Videla

Publicado: 2022-06-16 / http://dx.doi.org/10.20960/nh.04290

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Revisión: The effect of perioperative immunonutrition on patients undergoing esophagectomy: a systematic review and updated meta-analysis

Yun Zhou , Tian-Tian Li , Zhi-liang Yang , Zhi-Ming Tan , Chi-Fen Yang , Zheng Wang

Publicado: 2022-07-25 / http://dx.doi.org/10.20960/nh.04371

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Revisión: Inmunonutrición, evidencias y experiencias

Cristina Tejera Pérez , Cristina Guillín Amarelle , Nazareth Rodríguez Novo , Gloria Lugo Rodríguez , Beatriz Mantiñán Gil , Regina Palmeiro Carballeira , Francisco Pita Gutiérrez , Rosa Argüeso Armesto , Ana Cantón Blanco , Manuel Antonio Botana López , María Teresa Fernández López , Virginia Muñoz Leira , Santiago Rodeiro Marta , Miguel Ángel Martínez Olmos

Publicado: 2022-05-05 / http://dx.doi.org/10.20960/nh.04226

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Trabajo Original: Calidad de la alimentación en preescolares y escolares en Chile durante la pandemia de COVID-19

Nelson Hun Gamboa , Massiel Salazar , Sebastián Aliste , Camilo Aguilera , María Elvira Cárdenas

Publicado: 2022-08-01 / http://dx.doi.org/10.20960/nh.04383

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Revisión: Vitamina D y polimorfismos de los genes VDR y GC en la severidad y mortalidad por COVID-19. Una revisión sistemática

Giulia Camporesi , Regina Hernández Payró , Tania Levy Esses , María José Peláez Samperio , Adrián Macho González , Francisco J. Sánchez-Muniz

Publicado: 2022-06-23 / http://dx.doi.org/10.20960/nh.04299

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Trabajo Original: Efecto antiinflamatorio del suero de leche de diferentes especies tras una digestión in vitro

Teresa Sánchez-Moya , Siham Ydjedd , Carmen Frontela-Saseta , Rubén López Nicolás , Gaspar Ros-Berruezo

Publicado: 2022-09-21 / http://dx.doi.org/10.20960/nh.04451

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Trabajo Original: Evolución de la dieta y la actividad física de los estudiantes universitarios tras la pandemia de COVID-19

Almudena Tárraga Marcos , Julio Antonio Carbayo Herencia , Josefa Maria Panisello Royo , José Francisco López Gil , Loreto Tárraga Marcos , Pedro Juan Tárraga López

Publicado: 2022-09-01 / http://dx.doi.org/10.20960/nh.04420

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Trabajo Original: Inequalities in the association between adherence to the Mediterranean diet and physical fitness in the young population during the COVID-19 lockdown

Javier Brazo Sayavera , Inácio Crochemore-Silva , Bruno Bizzozero Peroni , Noelia González-Gálvez , Edina Maria de Camargo , José Francisco López-Gil

Publicado: 2022-05-04 / http://dx.doi.org/10.20960/nh.04225

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Revisión: Influencia de la dieta en el riesgo de infección y de gravedad de la COVID-19: una revisión sistemática

Ester Leno-Durán , Marcos Micha Mabale , Marina García-Pérez , Aurora Bueno-Cavanillas , Rocío Barrios-Rodríguez , Pilar Requena

Publicado: 2022-09-20 / http://dx.doi.org/10.20960/nh.04448

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Trabajo Original: Feeding intolerance during prolonged prone position in overweight and obese patients with severe COVID-19

Iván Armando Osuna-Padilla , Nadia Carolina Rodríguez-Moguel , Laurie Abril López-Orduña , Ana Lucía Gómez-Rodríguez , Alan García-Grimaldo , Sebastián Rodríguez-Llamazares , Ismael Maldonado-Beltrán , Martín Armando Ríos-Ayala , Carmen Margarita Hernández-Cárdenas

Publicado: 2022-11-28 / http://dx.doi.org/10.20960/nh.04553

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Revisión: Controversia 1. Papel de la albúmina en la valoración nutricional

José Pablo Suárez Llanos

Publicado: 2023-03-10 / http://dx.doi.org/10.20960/nh.04676

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Trabajo Original: The CONUT score predicts the length of hospital stay and the risk of long COVID

Zi-Wen Zhao , Qin Chen , Xin-Tao Zhang , Yu-Kun Luo

Publicado: 2023-02-22 / http://dx.doi.org/10.20960/nh.04656

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Trabajo Original: Physical activity as a mediator of the association of body mass index change with anxiety/depression symptoms in Brazilian adults during COVID-19

Edina Maria de Camargo , José Francisco López Gil , Cristiane Galvao Costa , Pedro Juan Tárraga López , Wagner de Campos , Sergio Gregorio da Silva

Publicado: 2023-04-02 / http://dx.doi.org/10.20960/nh.04716

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Trabajo Original: Correlation between dysphagia and serum albumin levels and prognosis: a retrospective study

Pingping Zhang , Hai-Yang Feng , De-Zhi Lu , Ting-Ting Li , Hui Zhang , Xiao-Wen Wang , Wen-Bo Liu

Publicado: 2022-09-20 / http://dx.doi.org/10.20960/nh.04444

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Trabajo Original: Lifestyles of 2- to 11-year-old children during the COVID-19 pandemic

Erika Mayorga-Borbolla , Danae Gabriela Valenzuela-Bravo , María del Carmen Morales-Ruán , Ignacio Méndez-Gómez Humarán , Teresa Shamah-Levy

Publicado: 2023-04-15 / http://dx.doi.org/10.20960/nh.04738

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Trabajo Original: It is not just about prescription. A cohort study of the impact of enteral nutrition on mortality of hospitalized patients with COVID-19

Adriana Flores-López , Gabriela Quiroz-Olguin , Alejandro Gabriel González-Garay , Aurora E. Serralde-Zúñiga

Publicado: 2023-06-22 / http://dx.doi.org/10.20960/nh.04828

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Revisión: Inmunonutrición y (su impacto en la) salud. Micronutrientes y factores debilitantes

Anna Bach-Faig , Inmaculada Ferreres Giménez , María Gloria Pueyo Alamán

Publicado: 2023-09-19 / http://dx.doi.org/10.20960/nh.04945

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Trabajo Original: Health habits during lockdown for COVID-19 in Spain and its effect on weight

José I. Baile , María J. González-Calderón , MARIA FRENZI RABITO ALCON , Eva Izquierdo Sotorrío

Publicado: 2023-04-18 / http://dx.doi.org/10.20960/nh.04740

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Trabajo Original: Efectividad de la inmunonutrición en el manejo nutricional perioperatorio del cáncer gástrico

Ángel Martínez González , José Llópiz Castedo , Pedro Rodeiro Escobar , Manuella González Nunes , Bárbara Fernández López , María de los Ángeles García Cardoner , Francisco Javier Fraile Amador , Samuel Rodríguez Zorrilla , María Inmaculada Martínez González , Santiago Enrique Rodeiro Marta

Publicado: 2023-09-14 / http://dx.doi.org/10.20960/nh.04934

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Trabajo Original: Desarrollo y validación de la puntuación de calidad alimentaria en el ELSA-Brasil

Carla Moronari de Oliveira Aprelini , Jordana Herzog Siqueira , Haysla Xavier Martins , Taísa Sabrina Silva Pereira , Yazareni José Mercadante Urquía , Maria del Carmen Bisi Molina

Publicado: 2023-01-10 / http://dx.doi.org/10.20960/nh.04598

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Trabajo Original: Nutritional status and its relationship with COVID-19 prognosis in hemodialysis patients

Paz Andrea Bersano-Reyes , Gema Nieto Martínez , Alicia Cana-Poyatos , Paula Guerrero Sanz , Rafa García-Maset , Alicia García-Testal

Publicado: 2023-07-07 / http://dx.doi.org/10.20960/nh.04850

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Trabajo Original: Healthcare resource utilization among critically-ill COVID-19 survivors: results from the NUTRICOVID study

Julia Álvarez Hernández , Pilar Matía Martín , Emilia Cancer Minchot , Cristina de la Cuerda Compés

Publicado: 2024-01-12 / http://dx.doi.org/10.20960/nh.05140

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Carta Editor: Impacto de la nutrición enteral en la mortalidad de pacientes hospitalizados con COVID-19

Mónica Zúñiga González

Publicado: 2024-04-05 / http://dx.doi.org/10.20960/nh.05256

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Trabajo Original: Evaluation of depression, anxiety, risky eating behaviors, eating habits and physical activity after the COVID-19 pandemic among adolescents in Mexico City

Diva Guadalupe Sotomayor Terán , Irina Lazarevich , Rey Gutiérrez Tolentino , Gerardo Leija Alva , Jorge Armando Barriguete Meléndez , Claudia Cecilia Radilla Vázquez

Publicado: 2023-12-12 / http://dx.doi.org/10.20960/nh.05083

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Carta Editor: Nutritional status, COVID-19 prognosis and hemodialysis patients

Hinpetch Daungsupawong , Viroj Wiwanitkit

Publicado: 2024-04-27 / http://dx.doi.org/10.20960/nh.05287

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Trabajo Original: Effects of COVID-19 lockdown on children´s sleep quality, physical activity, screen time, and diet

Roberto López-Iracheta , Nerea Martín Calvo , Laura Moreno-Galarraga , José Manuel Moreno Villares

Publicado: 2023-11-26 / http://dx.doi.org/10.20960/nh.05051

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Trabajo Original: Change in leisure-time physical activity and perception of weight gain during the COVID-19 pandemic: results from the ELSA-Brasil Cohort

Haysla Xavier Martins , Jordana Herzog Siqueira , Carla Moronari de Oliveira Aprelini , Sheila Maria Alvim de Matos , Taísa Sabrina Silva Pereira , Maria del Carmen Bisi Molina

Publicado: 2024-05-02 / http://dx.doi.org/10.20960/nh.05294

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Trabajo Original: Predictive values of body mass index, prognostic nutritional index and C-reactive protein to prealbumin ratio for prognosis of patients receiving radical gastrectomy

Yijie Yang , Jiale Yang , Lu Xu

Publicado: 2024-07-29 / http://dx.doi.org/10.20960/nh.05445

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Trabajo Original: Marcador albúmina-mioestatosis asistido por una herramienta de inteligencia artificial como factor pronóstico en pacientes con cáncer colorrectal metastásico

Daniel de Luis , David Primo , Olatz Izaola , Israel Sánchez Lite , Juan José López Gómez

Publicado: 2024-12-27 / http://dx.doi.org/10.20960/nh.05687

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