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Objective: To evaluate the prognostic capacity of the Inflammatory-Nutritional Index (INI) in gastrointestinal and lung cancer patients. Methods: Longitudinal study, including patients from a chemotherapy service in Brazil, between July 2008 and May 2010. INI (Albumin/CRP) and nutritional status (by Subjective Global Assessment - SGA) were evaluated. Risk INI was defined as lower than 0.35. The mean follow-up of survival was 1.6 year. Statistical analyses were performed using Stata 11.1™. Results: 74 patients participated in the study, mean age 63.4, most of them male (58%) and presenting gastrointestinal cancer (71%). Malnutrition was identified in 87% of the patients (22% severely malnourished). The mean INI was 2.67 and 54% of the patients had INI levels considered as risk. During the follow-up there were 49 deaths (66%). The median survival time for INI risk patients was significantly shorter than for normal INI ones (p = 0,002). It took 0.78 year for the INI risk subsample to decline 50%, while it took 2.78 year for the normal INI subsample. INI risk and severe malnutrition were independent predictors for poor survival. Conclusion: The INI showed prognostic capacity in this sample and may be a useful tool, based on routinely available blood tests, to assess cancer patients.
Palabras Clave: Biomarkers. Cachexia. Longitudinal study. Serum markers.
Alberto Miján De La Torre
Alexandra Gonçalves , Joana Silva , Pedro Moreira , Patrícia Padrao
Patrícia Padrao , Mafalda Neto , Ana Catarina Oliveira , André Moreira , Pedro Moreira
Beatriz Escudero Paniagua , Alicia Aguilar-martínez , Begoña Manuel Keenoy
Natalia Zurita-corvalan , Rodrigo Nanjari , Nathalia Fernández-cueto , María Paz Cid-arnes , Tamara Huber-pérez , Patricio Solís-urra , Carlos Cristi-Montero
Natália Yumi Noronha , Marcela Augusta De Souza Pinhel , Carolina Ferreira Nicoletti , Driele Cristina Gomes Quinhoneiro , Vitor Caressato Pinhanelli , Bruno Affonso Parenti Oliveira , Cristiana Cortes-Oliveira , Heitor Bernardes Pereira Delfino , Leticia Santana Wolf , Fabiani Gai Frantz , Júlio Sergio Marchini , Carla Barbosa Nonino
Oscar Geovanny Enríquez Martínez , Vivian Cristine Luft , Carolina Perim de Faria , Maria del Carmen Bisi Molina
Ricardo Fernández-Musoles , Aurora García Tejedor , José Moisés Laparra
Kliver Antonio Marin , Helen Hermana Miranda Hermsdorf , Fabiane Aparecida Canaan Rezende , Maria do Carmo Gouveia Peluzio , Antônio José Natali
Edilene Maria de Oliveira , Renata Pereira da Silva , Maria da Conceição Chaves de Lemos , Maria Goretti Pessoa de Araújo Burgos , Denise Maria Nascimento Costa , Regiane Maio
Aranzazu Recio Linares , Carolina Bezanilla López , Alberto Barasoain Millán , Mikel Domínguez Uribe-Echevarría , Clara García Rodríguez , Marta Torrejón López , Elia Pérez Fernández , Gonzalo Botija Arcos , Alfonso Barrio Merino
Yénifer Gamarra-Morales , Jorge Molina-López , Lourdes Herrera-Quintana , Héctor Vázquez-Lorente , Elena Planells
Mabelle Alves Ferreira de Lima , Karla Simone Costa de Souza , César Endrigo Silva de Andrade , Marcela Abbott Galvão Ururahy , Paulo José de Medeiros , Maurício Galvão Pereira , José Bruno de Almeida , Karine Cavalcanti Maurício Sena Evangelista , Adriana Augusto de Rezende
Alvin R. Acosta Magaña , Armando García Guerra , Veronica Mundo Rosas , Amado D. Quezada Sánchez , Carlos Galindo Gómez , Fabiola Mejía Rodríguez , Ana Cecilia Fernández Gaxiola
Rosa Burgos Peláez , José Pablo Suárez Llanos , José Manuel García Almeida , Pilar Matía Martín , Samara Palma Milla , Alejandro Sanz Paris , Ana Zugasti Murillo , Ana Artero-Fullana , Alfonso Calañas Continente , M.ª Jesús Chinchetru , Katherine García Malpartida , Ángela González-Díaz Faes , Víctor González-Sánchez , María Laínez López , Juana Oliva Roldán , Clara Serrano-Moreno , Antonio Jesús Martínez-Ortega , José Joaquín Alfaro-Martínez
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