Trabajo Original
Glycemic Control and Oxidative Stress Markers and their relationship with the Thioredoxin Interacting Protein (TXNIP) gene in Type 2 Diabetic patients
Número de descargas:
7808
Número de visitas:
3515
Citas:
0
Compártelo:
Objective: To investigate the relationship between oxidative stress and biochemical parameters and the expression of TXNIP, IL-6, IL-1β and TNF-α in peripheral mononuclear cells (PMCs) from type-2 diabetic patients. Methods: We studied 60 males: 20 normal-weight type- 2 diabetic patients (NW), 20 obese diabetic patients (OB) and 20 controls (C). Biochemical and oxidative stress parameters were evaluated. PMCs were isolated and total RNA was extracted in order to determine the expression of TXNIP, IL-6, IL-1β and TNF-α by qRT-PCR. Results: OB had higher weight, BMI and abdominal circumference (One way ANOVA, p<0.0001). NW had higher fasting glycemia (One way ANOVA, p=0.0034) however OB had higher HbA1c (One way ANOVA, p<0.0001). OB also had higher hsCRP (One way ANOVA, p=0.0158). TBARS and AGES were elevated in both NW and OB (One way ANOVA, p<0.0001 and p=0.0008, respectively). Compared to OB and C participants, the expression of TXNIP was significantly higher in NW (Kruskal Wallis, p=0.0074); IL-1β, IL-6 and TNF-α transcripts were higher in NW and OB (Kruskal Wallis, p<0.0001, for all). In NW patients, the expression of TXNIP was positively correlated with fasting glycemia and AGES and negatively correlated with HOMA-β (r=0.72; r=0.59; r=-0.44, respectively, for all p<0.05), in OB there was correlation only with 8-Isoprostanes (r=0.42, p=0.046). Conclusions: Our results suggest that fasting glycemic control, independent of adiposity and nutritional status, represents a risk factor for β-cell dysfunction, increases oxidative stress markers and it is related with an elevation of TXNIP expression.
Palabras Clave: TXNIP. β-cell function. Inflammation. AGEs. Glycemic control.
Artículos Relacionados:
Trabajo Original: Efecto de la glutamina en el estrés oxidativo y la inflamación en un modelo de rata con insuficiencia hepática fulminante
Elizângela Gonçalves Schemitt , Josieli Raskopf Colares , Renata Minuzzo Hartmann , María Isabel Morgan-martins , Cláudio Augusto Marroni , M. Jesús Tuñón , Norma Possa Marroni
Trabajo Original: A randomized control trial for reduction of caloric and non-caloric sweetened beverages in young adults: effects in weight, body composition and blood pressure
Marisela Vázquez-durán , Arturo Orea-tejeda , Lilia Castillo-martínez , Ángeles Cano-garcía , Laura Téllez-olvera , Candace Keirns-davis
Revisión: The nutritional limitations of plant-based beverages in infancy and childhood
Isidro Vitoria
Artículo Especial: VII Lección Jesús Culebras. Respuesta inflamatoria sistémica y disfunción/ fracaso multiorgánico tras una agresión: implicaciones metabólicas
Abelardo García de Lorenzo y Mateos
Trabajo Original: High fat diet and high polyphenols beverages effects in enzymatic and non-enzymatic antioxidant activity
Vania Mattoso Ribeiro , Teresa Palmisciano Bede , Gabrielle S. Rocha , Sergio Barroso , Samuel Valença , Vilma Blondet De Azeredo
Trabajo Original: Efectos del ejercicio físico intervalado en la mejora del control glicémico de adultos obesos con insulinorresistencia
Verenna Dalmazzo , Álvaro Ponce , Pedro Delgado-Floody , Vanessa Carola Carrasco Alarcón , Cristian Martínez Salazar
Trabajo Original: Green tea supplementation improves oxidative stress biomarkers and modulates IL-6 circulating levels in obese women
Natália Yumi Noronha , Marcela Augusta De Souza Pinhel , Carolina Ferreira Nicoletti , Driele Cristina Gomes Quinhoneiro , Vitor Caressato Pinhanelli , Bruno Affonso Parenti Oliveira , Cristiana Cortes-Oliveira , Heitor Bernardes Pereira Delfino , Leticia Santana Wolf , Fabiani Gai Frantz , Júlio Sergio Marchini , Carla Barbosa Nonino
Trabajo Original: Recuperación funcional del paciente cardiorrespiratorio
Ana Cantón Blanco
Trabajo Original: Nutrición en insuficiencia renal crónica
Pilar Riobó Serván , Inmaculada Moreno Ruiz
Trabajo Original: Interleukine 6 and C-reactive protein predict growth impairment and acute malnutrition in children and adolescents with chronic kidney disease
Karen V. Sánchez Hernández , Alfredo Larrosa-Haro , Mercedes González Hita , Fabiola Martín del Campo López , Clío Chávez Palencia , Gustavo Pérez Cortez , Jacob Sandoval Pamplona , Édgar Rivera León
Trabajo Original: The inflammatory potential of Argentinian diet and oral squamous cell carcinoma
Dante Gustavo Secchi , Laura Rosana Aballay , Nitin Shivappa , James R. Hebert , María Fernanda Galíndez Costa , Mabel Brunotto
Trabajo Original: Interdisciplinary therapy had positive effects on inflammatory state, mediated by leptin, adiponectin, and quality of diet in obese women
Carolina Kim Shiba , Ana Raimunda Dâmaso , Samantha Ottani Rhein , Paola Próspero Machado , Deborah Cristina Landi Masquio , Lila Missae Oyama , João Augusto Barreto Lombardi , Leonardo Lo Duca , Lian Tock , Gabriela Iervolino Oliveira , Raquel Munhoz da Silveira Campos
Trabajo Original: Metodología multidisciplinar y dieta cetogénica en la práctica clínica real: eficacia y rapidez en la pérdida de peso. Análisis de supervivencia. Estudio PROMET Lipoinflamación
Germán Guzmán , Ignacio Sajoux , Rocio Aller , Olatz Izaola Jáuregui , Daniel de Luis
Trabajo Original: Sarcopenia and inflammation in patients undergoing hemodialysis
Elane Viana Furtado Hortegal , Janete Janete Daniel Alencar Alves , Elton Jonh Freitas Santos , Liliane Carvalho Rodrigues Nunes , Jacqueline Carvalho Galvão da Silva , Rafael Ferreira Nunes , Dejane de Almeida Melo , Suena Cristina Rodrigues de Carvalho , Ana Karina Teixeira da Cunha França , Elisângela Milhomem dos Santos , Alcione Miranda dos Santos
Revisión: Hipótesis sobre las conexiones entre COVID-19 severo en niños y nutrición: una revisión narrativa
Ximena León-Lara , Ariana Vargas-Castillo , Azalia Avila-Nava , Martha Guevara-Cruz , Aurora E Serralde Zúñiga , Isabel Medina-Vera
Trabajo Original: Relationship between BsmI polymorphism and VDR gene methylation profile, gender, metabolic profile, oxidative stress, and inflammation in adolescents
Lavoisiana Lacerda de Lucena , Alexandre Sérgio Silva , Rayner Anderson Ferreira do Nascimento , Darlene Camati Persuhn , Juliana Padilha Ramos Neves , Maria José Carvalho Costa , Dayana Joyce Marques Queiroz , Rafaela Lira Formiga Covalcanti de Lima , Raquel Patrícia Ataíde de Lima , Maria Paula de Paiva , Naila Francis Paulo de Oliveira , Maria da Conceição Rodrigues Gonçalves
Trabajo Original: Psoas muscle mass, nutritional status, inflammation, and their relationship with prognosis in patients with pancreatic adenocarcinoma
İlhan Yıldırım , Tezcan Kaya , Kubilay İşsever , Ahmed Cihad Genç , Alper Karacan , Attila Önmez , İlhan Hacıbekiroğlu
Artículo Especial: The reduction of the metabolyc syndrome in Navarra-Spain (RESMENA-S) study; a multidisciplinary strategy based on chrononutrition and nutritional education, together with dietetic and psychological control
Trabajo Original: Systemic inflammation and carotid diameter in obese patients: pilot comparative study with flaxseed powder and cassava powder
Trabajo Original: Influencia de los carotenoides sobre los marcadores de riesgo cardiometabólico en mujeres peri y posmenopáusicas
Aina Tomás Luiz , Gala Martín Pozuelo , Inmaculada González Navarro , Laura Elvira Torales , Helena Ponce , Rocío González Barrio , Javier García Alonso , María Jesús Periago
Revisión: Efectos beneficiosos del chocolate en la salud cardiovascular
Trabajo Original: Parámetros hormonales e inflamatorios en un grupo de mujeres con sobrepeso/obesidad
Trabajo Original: Inflammatory mediators and immune response in Mexican adolescents
Trabajo Original: Sagital abdominal diameter, but not waist circumference is strongly associated with glycemia, triacilglycerols and HDL-c levels in overweight adults
Revisión: Effects of low carbohydrate diets on weight and glycemic control among type 2 diabetes individuals: a systemic review of RCT greater than 12 weeks
Trabajo Original: Evaluación de la eficacia de un suplemento oral en polvo enriquecido con ácido eicosapentaenoico en un grupo de pacientes con cáncer
Trabajo Original: Niveles de vitamina A y zinc en pacientes de cirugía gastroenterológica. Relación con la inflamación y la aparición de complicaciones postoperatorias
Trabajo Original: Obesidad y su relación con marcadores de inflamación y ácidos grasos de eritrocito en un grupo de adolescentes obesos
Revisión: The influence of endotoxemia on the molecular mechanisms of insulin resistance
Trabajo Original: Nutritional status, systemic inflammation and prognosis of patients with gastrointestinal cancer
Trabajo Original: Dietary intake increases serum levels of carboxymethil-lysine (CML) in diabetic patients
Revisión: The role of hyperglycemia in the induction of oxidative stress and inflammatory process
Revisión: Gut microbiota and the development of obesity
Trabajo Original: Hypoalbuminemia and other prognostic factors of mortality at different time points after ischemic stroke
Trabajo Original: Does fetuin-A mediate the association between pro-inflammatory diet and type-2 diabetes mellitus risk?
Kadriye Toprak , Süleyman Görpelioğlu , Ahmet Özsoy , Şeyda Özdemir , Aylin Ayaz
Trabajo Original: Dried apples enriched with mandarin juice by vacuum impregnation improve antioxidant capacity and decrease inflammation in obese children
Trabajo Original: Predictive ability of the anthropometric and body composition indicators for detecting changes in inflammatory biomarkers
Trabajo Original: Conicity index as a contributor marker of inflammation in haemodialysis patients
Trabajo Original: Estudio de dos variantes de la puntuacion de riesgo nutricional “NUTRIC” en pacientes criticos ventilados
Trabajo Original: Serum uric acid can predict higher C-reactive protein levels in apparently healthy men
Trabajo Original: Association between nutritional status, C-reactive protein, adiponectin and HOMA-AD in Brazilian children
Revisión: Adhesion molecules and chemokines: relation to anthropometric, body composition, biochemical and dietary variables
Revisión: Glycemic index role on visceral obesity, subclinical inflammation and associated chronic diseases
Trabajo Original: Ferritin in hypertensive and diabetic women before and after bariatric surgery
Trabajo Original: Effects of dietary supplementation with lemon verbena extracts on serum inflammatory markers of multiple sclerosis patients
Trabajo Original: Fructose intake: is there an association with uric acid levels in nondialysis-dependent chronic kidney disease patients?
Trabajo Original: Metabolic syndrome and its components are strongly associated with an inflammatory state and insulin resistance in the pediatric population
Trabajo Original: Cut-off values of waist circumference to predict metabolic syndrome in obese adolescents
Trabajo Original: Cowpea protein reduces LDL-cholesterol and apolipoprotein B concentrations, but does not improve biomarkers of inflammation or endothelial dysfunction in adults with moderate hypercholesterolemia
Revisión: Inflammatory markers in relation to body composition, physical activity and assessment of nutritional status of the adolescents
Revisión: Hepatic inflammatory biomarkers and its link with obesity and chronic diseases
Revisión: Inflamación y obesidad (lipoinflamación)
Trabajo Original: Reduction of serum advanced glycation end-products with a low calorie Mediterranean diet
Trabajo Original: Effects of exercise on inflammation in cardiac rehabilitation
Revisión: Influencia de los ácidos grasos poliinsaturados en la prevención y promoción del cáncer
Trabajo Original: The consumption of acai pulp changes the concentrations of plasminogen activator inhibitor-1 and epidermal growth factor (EGF) in apparently healthy women
Trabajo Original: Macronutrient intake is correlated with dyslipidemia and low-grade inflammation in childhood obesity but mostly in male obese
Trabajo Original: Inflammatory, nutritional and clinical parameters of individuals with chronic kidney disease undergoing conservative treatment
Trabajo Original: Serum concentration of nitric oxide in women smokers and nonsmokers with overweight
Trabajo Original: Behavior of adipokines after a year follow-up in the Obesity Outpatient Clinic for Children and Adolescents
Trabajo Original: Effectiveness of immunonutrition on inflammatory markers in patients with cancer; randomized clinical trial
Revisión: Consumption of cherries as a strategy to attenuate exercise-induced muscle damage and inflammation in humans
Trabajo Original: Waist-to-height ratio cut-off points to predict obesity in adolescents and associa-tion with inflammatory markers
Wyllyane Rayana Chaves Carvalho , Ana Karina Teixeira da Cunha França , Alcione Miranda dos Santos Alcione , Luana Lopes Padilha , Eduarda Gomes Bogea
Trabajo Original: Dietary inflammatory index and its association with leptin and adiponectin in Uygur overweight/obese adults
Kaibinuer Zaibibuli , Dina Muheyati , Mei-Xia Lv , Guliqiekeran Aisike , Muhairemu Jielili , Jing Zhao , Ayinuer Aihemaiti , Jia Han
Trabajo Original: Association between nutritional status and platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization
Hongyan Duan , Jianfeng Zhang , Peng Wang , Jie Zhang , Jianwei Jiang
Trabajo Original: Efecto de un multivitamínico sobre la resistencia a la insulina, inflamación y estrés oxidante en un modelo de obesidad inducida en ratas Wistar
José Antonio Palma-Jacinto , Isela Santiago-Roque , María del Rocío Coutiño-Rodríguez , Omar Elind Arroyo-Helguera
Trabajo Original: Determination of inflammation by TNF-alpha and IL-10 levels in obese children and adolescents
Ali Gul , Resul Yilmaz
Trabajo Original: Association between the dietary inflammatory index and pelvic inflammatory disease - Findings from the NHANES data (2015-2018)
Juanjuan Ma , Panwei Hu , Qinhua Zhang , Jian Pei
Trabajo Original: Effects of 3-day fasting on secretory IgA concentration in the saliva and lymphotoxin alpha expression in healthy volunteers: a proof of concept study
Gabriela Quiroz-Olguín , Gabriela Gutiérrez-Salmeán , Angélica I. Borja-Margno , Adriana Flores-López , Martha Guevara-Cruz , Francisco Enrique Gómez , Aurora E. Serralde-Zúñiga
Trabajo Original: Exploring the link between the Naples prognostic score and the cardio-ankle vascular index
Ercan Aydın , Savaş Özer , Ahmet Özderya , Emre Yılmaz , Armağan Kaya , Altuğ Ösken , Gökhan Yerlikaya , Selçuk Yaylacı
Trabajo Original: The empirical pattern of dietary inflammation is unrelated to nutritional status in college students
Noenia Alves de Araújo , Helena Alves de Carvalho Sampaio , Antônio Augusto Ferreira Carioca , Bruna Yhang da Costa Silva , Anael Queirós Silva Barros , Ruth Pereira Costa da Silva , Carlos Cardoso Neto , Antônio Lucas Fernandes Leal
Artículos más populares
Artículo Especial: VII Lección Jesús Culebras. Respuesta inflamatoria sistémica y disfunción/ fracaso multiorgánico tras una agresión: implicaciones metabólicas
Ante cualquier agresión, el organismo pone en marc...
Artículo Especial: VIII Lección Jesús Culebras. Medicina intensiva, nutrición e hiperglucemia: una relación muy estrecha
El paciente crítico presenta una respuesta metaból...
-
Licencia creative commons: Open Access bajo la licencia Creative Commons 4.0 CC BY-NC-SA
https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
