Claudia C.H. Krüger, Thaise D. Azevedo, Marina Talamini Piltz, Ágatha Transfeld Silva, Lys Mary Bileski Cândido
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Introduction: casein-derived peptides can be liberated both in vivo via normal digestion of casein, as well as in vitro via enzymatic hydrolysis. These peptides were suggested to have biological activity. Objectives: the aim of this study was to describe the production and characterization of casein peptides and to explore the potential of these peptides as an option for low-phenylalanine diets. Methods: peptides were produced by tryptic hydrolysis of sodium caseinate and acid precipitation with HCl, followed by precipitation with ethanol or aggregation of CaCl2 or ZnSO4. Results: the amino acid analysis revealed a significant reduction in the amount of phenylalanine from the original protein. Conclusion: casein-derived peptides could be a future alternative of short chain peptides to low-phenylalanine formulations.
Palabras Clave: Casein. Peptides. Phenylalanine. Phenylketonuria.
Nadia Reyna , Rafael Moreno-rojas , Laura Mendoza , Karla Parra , Sergia Linares , Eduardo Reyna , Fernando Cámara-martos
Ruth Lezama García , Luis Chel Guerrero , Juan José Acevedo-Fernández , David Betancur Ancona
Laura Soriano Romaní , Juan Antonio Nieto Fuentes , Lidia Tomás Cobos , Elena Diez Sánchez
José Luis Bizueto Monroy , Ricardo E. Ramírez-Orozco , Judith Martín del Campo Cervantes , Susana Berenice Esparza Ramos , Ivonne González Espinosa , Said Cuéllar Valencia , Alan Gutiérrez Ramírez
Thais Regina Mezzomo , Marcia Regina Messaggi Gomes Dias , Tatiane Santos , Rosana Marques Pereira
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