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Nutrición Hospitalaria 04148 / http://dx.doi.org/10.20960/nh.04148

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The effect of omega-3 polyunsaturated fatty acids on stroke treatment and prevention: a systematic review and meta-analysis

Qian Xu, Lingling Du, Heng Gu, Meng Ji, Ling Zhan

Prepublicado: 2022-08-02

Publicado: 2022-08-02

VOLUMEN 39, NÚM. 4, julio-agosto (2022), PAG. 924-935

Logo Descargas Número de descargas: 9458 Logo Visitas Número de visitas: 4121 Citas Citas: 2

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Background: in recent years, n-3 PUFAs have been confirmed to be associated with cardiovascular and cerebrovascular diseases, but the link between n-3 PUFAs and stroke remains controversial. Objective: this study aimed to evaluate the association between n-3 PUFAs and stroke. Methods: we performed a comprehensive search of the following electronic databases: PubMed, Embase, Cochrane Library, Web of Science and CNKI. Literature screening and quality assessment were performed according to inclusion and exclusion criteria. Cochrane’s tool was used to assess the methodological components of each study, and the Stata 15.1 software was used to perform the meta-analysis. Results: a total of 18 RCTs were included, and the meta-analysis showed no differences in vascular disease-related death between the n-3 PUFA and control groups (RR, 0.95, 95 % CI: 0.89 to 1.01, p = 0.114 > 0.05). However, there was a significant difference in the lower n-3 PUFA dose subgroup (RR, 0.93, 95 % CI: 0.87 to 0.99, p = 0.034 < 0.05). Oral administration of n-3 PUFAs did not significantly reduce the risk of the following cerebrovascular accidents: stroke (RR = 1.00, 95 % CI: 0.93 to 1.07, p = 0.983 > 0.05), ischemic stroke (RR = 0.99, 95 % CI: 0.896 to 1.094, p = 0.841 > 0.05), hemorrhagic stroke (RR = 1.249, 95 % CI: 0.939 to 1.662, p = 0.127 > 0.05) and TIA (RR = 1.016, 95 % CI: 0.882 to 1.170, p = 0.824 > 0.05). The levels of TC (SMD, -0.167, 95 % CI: −0.193 to -0.141, p = 0 < 0.05) and TG (SMD, -0.065, 95 % CI: -0.087 to -0.042, p = 0 < 0.05) in the n-3 PUFA group were significantly decreased, but no significant improvement in the LDL (SMD, 0.022, 95 % CI: 0.005 to 0.040, p = 0.889 > 0.05) and HDL (SMD, 0.008, 95 % CI: -0.009 to 0.025, p = 0.368 > 0.05) levels was observed. Conclusion: this systematic review and meta-analysis suggests that treatment with low-dose n-3 PUFAs can reduce cerebrovascular disease-related death. After the oral administration of n-3 PUFAs, the levels of TC and TG decreased significantly, but n-3 PUFAs did not prevent the occurrence of cerebrovascular accidents or improve LDL or HDL levels.

Palabras Clave: n-3 PUFAs; stroke; meta-analysis

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Fan, Xuehui, He, Chenyiyi, Xu, Jing, Ye, Ruixue, Zhao, Jingpu, Wang, Yulong (2025) Factors influencing short-term and long-term survival rates in stroke patients receiving enteral nutrition: a machine learning approach using MIMIC-IV database. BMC Neurology

Starck, Carlene S., Cassettari, Tim, Beckett, Emma, Marshall, Skye, Fayet-Moore, Flavia (2024) Priority nutrients to address malnutrition and diet-related diseases in Australia and New Zealand. Frontiers in Nutrition

[1]MozaB arian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics - 2016 update. Circulation 2016;133(4):e38-e360.
DOI: 10.1161/CIR.0000000000000350

[2]Krishnamurthi Rita V and Ikeda Takayoshi and Feigin Valery L. Global, Regional and Country-Specific Burden of Ischaemic Stroke, Intracerebral Haemorrhage and Subarachnoid Haemorrhage: A Systematic Analysis of the Global Burden of Disease Study 2017.[J]. Neuroepidemiology, 2020, 54(2) : 171-179.

[3]Roth Gregory A. et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study[J]. Journal of the American College of Cardiology, 2020, 76(25) : 2982-3021.

[4]Virani Salim S et al. Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association.[J]. Circulation, 2020, 141(9) : e139-e596.

[5]Donkor E S . Stroke in the 2 1 s t Century: A Snapshot of the Burden, Epidemiology, and Quality of Life[J]. Stroke Research and Treatment, 2018, 2018:1-10.
DOI: 10.1155/2018/3238165

[6]Jacqueline I , Philip C . The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic Review[J]. International Journal of Molecular Sciences, 2018, 19(2):532.
DOI: 10.3390/ijms19020532

[7]Carracedo M, Artiach G, Arnardottir H, et al. The resolution of inflammation through omega-3 fatty acids in atherosclerosis, intimal hyperplasia, and vascular calcification[C]//Seminars in immunopathology. Springer Berlin Heidelberg, 2019, 41(6): 757-766.

[8]Araujo Pedro,Belghit Ikram,Aarsæther Niels et al. The Effect of Omega-3 and Omega-6 Polyunsaturated Fatty Acids on the Production of Cyclooxygenase and Lipoxygenase Metabolites by Human Umbilical Vein Endothelial Cells.[J] .Nutrients, 2019, 11: undefined.
DOI: 10.3390/nu11050966

[9]Davidson M H . Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid.[J]. Current Opinion in Lipidology, 2013, 24(6):467-474.
DOI: 10.1097/MOL.0000000000000019

[10]Tietge Uwe J F. Hyperlipidemia and cardiovascular disease: inflammation, dyslipidemia, and atherosclerosis.[J]. Current opinion in lipidology, 2014, 25(1) : 94-5.

[11]Yuan F, Wang H, Tian Y, et al. Fish oil alleviated high-fat diet–induced non-alcoholic fatty liver disease via regulating hepatic lipids metabolism and metaflammation: a transcriptomic study[J]. Lipids in health and disease, 2016, 15(1): 1-13.
DOI: 10.1186/s12944-016-0190-y

[12]Xiao H B, Liang L, Luo Z F, et al. Paeoniflorin regulates GALNT2-ANGPTL3-LPL pathway to attenuate dyslipidemia in mice[J]. European Journal of Pharmacology, 2018, 836: 122-128.
DOI: 10.1016/j.ejphar.2018.08.006

[13]Oscarsson J, Hurt-Camejo E. Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review[J]. Lipids in health and disease, 2017, 16(1): 1-13.
DOI: 10.1186/s12944-017-0541-3

[14]Lesley A. Stewart et al. Preferred Reporting Items for a Systematic Review and Meta-analysis of Individual Participant Data: The PRISMA-IPD Statement[J]. JAMA, 2015, 313(16) : 1657-1665.
DOI: 10.1001/jama.2015.3656

[15]Higgins Julian P T,Altman Douglas G,Gøtzsche Peter C et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials.[J] .BMJ, 2011, 343: d5928.
DOI: 10.1136/bmj.d5928

[16]Poppitt Sally D,Howe Colin A,Lithander Fiona E et al. Effects of moderate-dose omega-3 fish oil on cardiovascular risk factors and mood after ischemic stroke: a randomized, controlled trial.[J] .Stroke, 2009, 40: 3485-92.
DOI: 10.1161/STROKEAHA.109.555136

[17]Saito Geisi,Zapata Rodrigo,Rivera Rodrigo et al. Long-chain omega-3 fatty acids in aneurysmal subarachnoid hemorrhage: A randomized pilot trial of pharmaconutrition.[J] .Surg Neurol Int, 2017, 8: 304.
DOI: 10.4103/sni.sni_266_17

[18]Nicholls Stephen J,Lincoff A Michael,Garcia Michelle et al. Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial.[J] .JAMA, 2020, 324: 2268-2280.
DOI: 10.1001/jama.2020.22258

[19]Garbagnati F,Cairella G,De Martino A et al. Is antioxidant and n-3 supplementation able to improve functional status in post stroke patients? Results from the Nutristroke Trial.[J] .Cerebrovasc Dis, 2009, 27: 375-83.
DOI: 10.1159/000207441

[20]Itakura Hiroshige,Yokoyama Mitsuhiro,Matsuzaki Masunori et al. Relationships between plasma fatty acid composition and coronary artery disease.[J] .J Atheroscler Thromb, 2011, 18: 99-107.
DOI: 10.5551/jat.5876

[21]Foroughinia Farzaneh,Jamshidi Elaheh,Javanmardi Haniyeh et al. Effectiveness and safety of omega-3 fatty acids for the prevention of ischemic complications following carotid artery stenting: An early terminated pilot study.[J] .Iran J Neurol, 2018, 17: 11-17.

[22]Dangour Alan D,Allen Elizabeth,Elbourne Diana et al. Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial.[J] .Am J Clin Nutr, 2010, 91: 1725-32.
DOI: 10.3945/ajcn.2009.29121

[23]Risk and Prevention Study Collaborative Group.,Roncaglioni MC,Tombesi M,et al.n-3 fatty acids in patients with multiple cardiovascular risk factors.[J].N Engl J Med,2013,19:1800-8.
DOI: 10.1056/NEJMoa1205409

[24]Nissen Steven E,Lincoff A Michael,Wolski Kathy et al. Association Between Achieved ω-3 Fatty Acid Levels and Major Adverse Cardiovascular Outcomes in Patients With High Cardiovascular Risk: A Secondary Analysis of the STRENGTH Trial.[J] .JAMA Cardiol, 2021, 6(8): 910-917.

[25]Rist P M , Buring J E , Cook N R , et al. Effect of vitamin D and/or omega‐3 fatty acid supplementation on stroke outcomes: A randomized trial[J]. European Journal of Neurology.

[26]Brouwer Ingeborg A,Geleijnse Johanna M,Klaasen Veronique M et al. Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial.[J] .PLoS One, 2013, 8: e81519.
DOI: 10.1371/journal.pone.0081519

[27]Manson JE, Cook NR, Lee IM, et al. Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer. N Engl J Med. 2019;380(1):23-32.
DOI: 10.1056/NEJMoa1811403

[28]Galan P,Kesse-Guyot E,Czernichow S,et al.Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial.[J].BMJ,2010,:c6273.
DOI: 10.1136/bmj.c6273

[29]Tanaka Kortaro,Ishikawa Yuichi,Yokoyama Mitsuhiro et al. Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: subanalysis of the JELIS trial.[J] .Stroke, 2008, 39: 2052-8.
DOI: 10.1161/STROKEAHA.107.509455

[30]Bosch, J, Gerstein, et al. n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia[J]. The New England journal of medicine, 2012.

[31]Harper C, Mafham M, Herrington W, et al. Comparison of the Accuracy and Completeness of Records of Serious Vascular Events in Routinely Collected Data vs Clinical Trial–Adjudicated Direct Follow-up Data in the UK: Secondary Analysis of the ASCEND Randomized Clinical Trial[J]. JAMA network open, 2021, 4(12): e2139748-e2139748.
DOI: 10.1001/jamanetworkopen.2021.39748

[32]Manson J , SS Bassuk, Cook N R , et al. Vitamin D, Marine n-3 Fatty Acids, and Primary Prevention of Cardiovascular Disease Current Evidence[J]. Circulation Research, 2020, 126(1):112-128.
DOI: 10.1161/CIRCRESAHA.119.314541

[33]ASCEND Study Collaborative Group, Bowman L, Mafham M, et al. Effects of n-3 Fatty Acid Supplements in Diabetes Mellitus. N Engl J Med. 2018;379(16):1540-1550.
DOI: 10.1056/NEJMoa1804989

[34]Alvarez Campano C G , Macleod M J , Thies F , et al. Marine-derived n-3 fatty acids therapy for stroke[J]. Cochrane database of systematic reviews (Online), 2017.
DOI: 10.1002/14651858.CD012815

[35]Nishizaki Yuji,Daida Hiroyuki,Optimal Dose of n-3 Polyunsaturated Fatty Acids for Cardiovascular Event Prevention.[J] .Circ Rep, 2020, 2: 260-264.
DOI: 10.1253/circrep.CR-20-0012

[36]Yokoyama Mitsuhiro,Origasa Hideki,Matsuzaki Masunori et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.[J] .Lancet, 2007, 369: 1090-8.
DOI: 10.1016/S0140-6736(07)60527-3

[37]Bhatt DL,Steg PG,Miller M,et al.Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia.[J].N Engl J Med,2019,1:11-22.
DOI: 10.1056/NEJMoa1812792

[38]Cai M,Zhang W,Weng Z,et al.Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids.[J].Aging Dis,2017,5:531-545.
DOI: 10.14336/AD.2017.0520

[39]Jiang X , Pu H , Hu X , et al. A Post-stroke Therapeutic Regimen with Omega-3 Polyunsaturated Fatty Acids that Promotes White Matter Integrity and Beneficial Microglial Responses after Cerebral Ischemia[J]. Translational Stroke Research, 2016, 7(6):548-561.
DOI: 10.1007/s12975-016-0502-6

[40]Lalancette-Hebert M , Julien C , Cordeau P , et al. Accumulation of Dietary Docosahexaenoic Acid in the Brain Attenuates Acute Immune Response and Development of Postischemic Neuronal Damage[J]. Stroke; a journal of cerebral circulation, 2011, 42(10):2903.
DOI: 10.1161/STROKEAHA.111.620856

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The effect of omega-3 polyunsaturated fatty acids on stroke treatment and prevention: a systematic review and meta-analysis

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