Nutrición Hospitalaria 05139 / http://dx.doi.org/10.20960/nh.05139

Trabajo Original

Causal effect of sarcopenia-related traits on the occurrence and prognosis of breast cancer - A bidirectional and multivariable Mendelian randomization study

Zhijian He, Lujia Zhu, Jie He, Xinwei Chen, Xiaoyang Li, Jian Yu

Prepublicado: 2024-04-12

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Background and aims: although sarcopenia is associated with several types of cancer, there is limited research regarding its effect on breast cancer. We aimed to explore the causality between sarcopenia-related traits and the incidence and prognosis of breast cancer. Methods: two-sample bidirectional and multivariate Mendelian randomization (MR) analyses were utilized in this study. Genome-wide association studies were used to genetically identify sarcopenia-related traits, such as appendicular lean mass, grip strength of both hands, and walking pace. Data on the incidence and prognosis of breast cancer were collected from two extensive cohort studies. Multivariate MR analysis was used to adjust for body mass index, waist circumference, and whole-body fat mass. The primary method used for analysis was inverse-variance weighted analysis. Results: a significant association was found between appendicular lean mass and ER- breast cancer (OR = 0.873, 95 % CI: 0.817-0.933, p = 6.570 × 10-5). Increased grip strength of the left hand was associated with a reduced risk of ER- breast cancer (OR = 0.744, 95 % CI: 0.579-0.958, p = 0.022). Stronger grip strength of the right hand was associated with prolonged survival time of ER+ breast cancer patients (OR = 0.463, 95 % CI: 0.242-0.882, p = 0.019). In the multivariable MR analysis, appendicular lean mass, grip strength of both hands, and walking pace were still genetically associated with the development of total breast cancer and ER-/+ breast cancer. Conclusions: several sarcopenia-related traits were genetically associated with the occurrence and prognosis of breast cancer. It is crucial for elderly women to increase their strength and muscle mass to help prevent breast cancer.

Palabras Clave: Breast cancer. Sarcopenia-related traits. Risk factor. Causal relationship. Mendelian randomization.

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Artículos Relacionados

Harbeck N, Gnant M. Breast cancer. Lancet 2017;389(10074):1134-50.
DOI: 10.1016/S0140-6736(16)31891-8

Nassif AB, Talib MA, Nasir Q, Afadar Y, Elgendy O. Breast cancer detection using artificial intelligence techniques: A systematic literature review. Artificial intelligence in medicine 2022;127:102276.
DOI: 10.1016/j.artmed.2022.102276

Britt KL, Cuzick J, Phillips KA. Key steps for effective breast cancer prevention. Nature reviews Cancer 2020;20(8):417-36.
DOI: 10.1038/s41568-020-0266-x

Torre LA, Siegel RL, Ward EM, Jemal A. Global Cancer Incidence and Mortality Rates and Trends--An Update. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016;25(1):16-27.
DOI: 10.1158/1055-9965.EPI-15-0578

Dixon-Suen SC, Lewis SJ, Martin RM, English DR, Boyle T, Giles GG, et al.. Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study. British journal of sports medicine 2022;56(20):1157-70.
DOI: 10.1136/bjsports-2021-105132

Burstein HJ, Curigliano G, Thürlimann B, Weber WP, Poortmans P, Regan MM, et al.. Customizing local and systemic therapies for women with early breast cancer: the St. Gallen International Consensus Guidelines for treatment of early breast cancer 2021. Ann Oncol 2021;32(10):1216-35.
DOI: 10.1016/j.annonc.2021.06.023

Petermann-Rocha F, Balntzi V, Gray SR, Lara J, Ho FK, Pell JP, et al.. Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 2022;13(1):86-99.
DOI: 10.1002/jcsm.12783

Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet 2019;393(10191):2636-46.
DOI: 10.1016/S0140-6736(19)31138-9

Yuan S, Larsson SC. Epidemiology of sarcopenia: Prevalence, risk factors, and consequences. Metabolism: clinical and experimental 2023;144:155533.
DOI: 10.1016/j.metabol.2023.155533

Prado CM, Orsso CE, Pereira SL, Atherton PJ, Deutz NEP. Effects of β-hydroxy β-methylbutyrate (HMB) supplementation on muscle mass, function, and other outcomes in patients with cancer: a systematic review. J Cachexia Sarcopenia Muscle 2022;13(3):1623-41.
DOI: 10.1002/jcsm.12952

Williams GR, Dunne RF, Giri S, Shachar SS, Caan BJ. Sarcopenia in the Older Adult With Cancer. J Clin Oncol 2021;39(19):2068-78
DOI: 10.1200/JCO.21.00102

Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, et al.. Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement. Jama 2021;326(16):1614-21.
DOI: 10.1001/jama.2021.18236

Yao S, Zhang M, Dong SS, Wang JH, Zhang K, Guo J, et al.. Bidirectional two-sample Mendelian randomization analysis identifies causal associations between relative carbohydrate intake and depression. Nature human behaviour 2022;6(11):1569-76.
DOI: 10.1038/s41562-022-01412-9

Sekula P, Del Greco MF, Pattaro C, Köttgen A. Mendelian Randomization as an Approach to Assess Causality Using Observational Data. Journal of the American Society of Nephrology: JASN 2016;27(11):3253-65.
DOI: 10.1681/ASN.2016010098

Verbanck M, Chen CY, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nature genetics 2018;50(5):693-8.
DOI: 10.1038/s41588-018-0099-7

Pei YF, Liu YZ, Yang XL, Zhang H, Feng GJ, Wei XT, et al.. The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study. Communications biology 2020;3(1):608.
DOI: 10.1038/s42003-020-01334-0

Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al.. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019;48(1):16-31.
DOI: 10.1093/ageing/afy169

Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al.. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS medicine 2015;12(3):e1001779.
DOI: 10.1371/journal.pmed.1001779

Liu C, Liu N, Zeng Y, Xiao B, Wang P, Zhou C, et al.. COVID-19 and sarcopenia-related traits: a bidirectional Mendelian randomization study. Frontiers in endocrinology 2023;14:1162936.
DOI: 10.3389/fendo.2023.1162936

Michailidou K, Lindström S, Dennis J, Beesley J, Hui S, Kar S, et al.. Association analysis identifies 65 new breast cancer risk loci. Nature 2017;551(7678):92-4.
DOI: 10.1038/nature24284

Guo Q, Schmidt MK, Kraft P, Canisius S, Chen C, Khan S, et al.. Identification of novel genetic markers of breast cancer survival. Journal of the National Cancer Institute 2015;107(5).

Chen X, Kong J, Pan J, Huang K, Zhou W, Diao X, et al.. Kidney damage causally affects the brain cortical structure: A Mendelian randomization study. EBioMedicine 2021;72:103592.
DOI: 10.1016/j.ebiom.2021.103592

Sedgwick P. Multiple hypothesis testing and Bonferroni's correction. BMJ (Clinical research ed) 2014;349:g6284.
DOI: 10.1136/bmj.g6284

Nolan E, Lindeman GJ, Visvader JE. Deciphering breast cancer: from biology to the clinic. Cell 2023;186(8):1708-28.
DOI: 10.1016/j.cell.2023.01.040

Escala-Garcia M, Morra A, Canisius S, Chang-Claude J, Kar S, Zheng W, et al.. Breast cancer risk factors and their effects on survival: a Mendelian randomisation study. BMC Med 2020;18(1):327.
DOI: 10.1186/s12916-020-01797-2

Gielen E, Dupont J, Dejaeger M, Laurent MR. Sarcopenia, osteoporosis and frailty. Metabolism: clinical and experimental 2023;145:155638.
DOI: 10.1016/j.metabol.2023.155638

Morlino D, Marra M, Cioffi I, Santarpia L, De Placido P, Giuliano M, et al.. Prevalence of Sarcopenia in Women with Breast Cancer. Nutrients 2022;14(9).
DOI: 10.3390/nu14091839

Xia L, Zhao R, Wan Q, Wu Y, Zhou Y, Wang Y, et al.. Sarcopenia and adverse health-related outcomes: An umbrella review of meta-analyses of observational studies. Cancer medicine 2020;9(21):7964-78.
DOI: 10.1002/cam4.3428

Jogiat UM, Sasewich H, Turner SR, Baracos V, Eurich DT, Filafilo H, et al.. Sarcopenia Determined by Skeletal Muscle Index Predicts Overall Survival, Disease-free Survival, and Postoperative Complications in Resectable Esophageal Cancer: A Systematic Review and Meta-analysis. Ann Surg 2022;276(5):e311-e8.
DOI: 10.1097/SLA.0000000000005452

Liu P, Chen S, Gao X, Liang H, Sun D, Shi B, et al.. Preoperative sarcopenia and systemic immune-inflammation index can predict response to intravesical Bacillus Calmette-Guerin instillation in patients with non-muscle invasive bladder cancer. Front Immunol 2022;13:1032907.
DOI: 10.3389/fimmu.2022.1032907

De Luca R, Gianotti L, Pedrazzoli P, Brunetti O, Rizzo A, Sandini M, et al.. Immunonutrition and prehabilitation in pancreatic cancer surgery: A new concept in the era of ERAS® and neoadjuvant treatment. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2023;49(3):542-9.
DOI: 10.1016/j.ejso.2022.12.006

Xie K, He D, Zhao T, Liu T, Tang M. Gastric Cancer with Sarcopenia: an Area Worth Focusing On. Current treatment options in oncology 2023;24(10):1305-27.
DOI: 10.1007/s11864-023-01122-y

Ashton E, Arrondeau J, Jouinot A, Boudou-Rouquette P, Hirsch L, Huillard O, et al.. Impact of sarcopenia indexes on survival and severe immune acute toxicity in metastatic non-small cell lung cancer patients treated with PD-1 immune checkpoint inhibitors. Clin Nutr 2023;42(6):944-53.
DOI: 10.1016/j.clnu.2023.03.023

Jang MK, Park S, Park C, Doorenbos A, Go J, Kim S. Hematologic toxicities, sarcopenia, and body composition change in breast cancer patients undergoing neoadjuvant chemotherapy. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2023;31(7):419.
DOI: 10.1007/s00520-023-07890-5

Klassen O, Schmidt ME, Ulrich CM, Schneeweiss A, Potthoff K, Steindorf K, et al.. Muscle strength in breast cancer patients receiving different treatment regimes. J Cachexia Sarcopenia Muscle 2017;8(2):305-16.
DOI: 10.1002/jcsm.12165

Caan BJ, Cespedes Feliciano EM, Prado CM, Alexeeff S, Kroenke CH, Bradshaw P, et al.. Association of Muscle and Adiposity Measured by Computed Tomography With Survival in Patients With Nonmetastatic Breast Cancer. JAMA oncology 2018;4(6):798-804.
DOI: 10.1001/jamaoncol.2018.0137

Mader T, Chaillou T, Alves ES, Jude B, Cheng AJ, Kenne E, et al.. Exercise reduces intramuscular stress and counteracts muscle weakness in mice with breast cancer. J Cachexia Sarcopenia Muscle 2022;13(2):1151-63.
DOI: 10.1002/jcsm.12944

Miao S, Jia H, Cheng K, Hu X, Li J, Huang W, et al.. Deep learning radiomics under multimodality explore association between muscle/fat and metastasis and survival in breast cancer patients. Briefings in bioinformatics 2022;23(6).
DOI: 10.1093/bib/bbac432

Burgess S, Davies NM, Thompson SG. Bias due to participant overlap in two-sample Mendelian randomization. Genetic epidemiology 2016;40(7):597-608.
DOI: 10.1002/gepi.21998

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