Nutrición Hospitalaria 04523 / http://dx.doi.org/10.20960/nh.04523

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The impact of docosahexaenoic acid on maternal mental health: scoping review

Olga Masot, Julio José Ochoa Herrera, Elena Paraíso Pueyo, Judith Roca, Jéssica Miranda, Ana Lavedán

Prepublicado: 2023-06-06

Publicado: 2023-07-28

VOLUMEN 40, NÚM. 4, julio-agosto (2023), PAG. 848-857

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Docosahexaenoic acid (DHA) is a polyunsaturated essential fatty acid from the omega-3 series that appears to be key to perinatal mental health. For this, the aim of this review is to evaluate the effect of DHA on maternal mental health during pregnancy and lactation with respect to depression and anxiety. The present scoping review was carried out following the methodology of Arksey and O’Malley (2005). The selection of studies was carried out in accordance with PRISMA by means of systematic searches in the PubMed, Scopus, PsycINFO and Medline databases. The results classified according to the effectiveness of DHA. In most (n = 9) of the 14 studies finally included, DHA plasma levels with or without other polyunsaturated omega-3 fatty acids were significantly lower in pregnant women with depressive and anxiety symptoms. However, no study reported a beneficial effect of DHA on mental health during the postpartum period. The majority used detection method was the Edinburgh Postpartum Depression Scale (n = 11). The prevalence of depressive symptoms ranged between 5.9 % and 50 %. As a conclusion, although more research is needed in this area, these exploratory results suggest that DHA could play an important role in preventing the pathogenesis of depression and anxiety during gestation.

Palabras Clave: Docosahexaenoic acid. Depression. Anxiety. Pregnancy. Postpartum. Review.

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Bibliografía
Artículos Relacionados

Innis SM. Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids. J Pediatr. 2003;143(4):1–8.
DOI: 10.1067/S0022-3476(03)00396-2

European Food Safety Authority (EFSA). Dietary Reference Values for nutrients Summary report [Internet]. 2017 [cited 2023 Mar 8]. p. 17. Available from: https://www.efsa.europa.eu/en/supporting/pub/e15121

Aparicio E, Martín-Grau C, Bedmar C, Serrat Orus NS, Basora J, Arija V, et al. Maternal Factors Associated with Levels of Fatty Acids, Specifically n-3 PUFA during Pregnancy: ECLIPSES Study. Nutrients. 2021;13(2):1–19.
DOI: 10.3390/nu13020317

Freeman MP, Sinha P. Tolerability of omega-3 fatty acid supplements in perinatal women. Prostaglandins Leukot Essent Fat Acids. 2007;77(3–4):203–8.
DOI: 10.1016/j.plefa.2007.09.004

De Giuseppe R, Roggi C, Cena H. n-3 LC-PUFA supplementation: Effects on infant and maternal outcomes. Eur J Nutr. 2014;53(5):1147–54.
DOI: 10.1007/s00394-014-0660-9

Manta-Vogli PD, Schulpis KH, Dotsikas Y, Loukas YL. The significant role of carnitine and fatty acids during pregnancy, lactation and perinatal period. Nutritional support in specific groups of pregnant women. Clin Nutr. 2020;39(8):2337–46.
DOI: 10.1016/j.clnu.2019.10.025

Lin PY, Huang SY, Su KP. A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol Psychiatry. 2010;68(2):140–7.
DOI: 10.1016/j.biopsych.2010.03.018

Levant B. N-3 (Omega-3) Polyunsaturated Fatty Acids in the Pathophysiology and Treatment of Depression: Pre-Clinical Evidence. CNS Neurol Disord - Drug Targets. 2013;12(4):450–9.
DOI: 10.2174/1871527311312040003

Newport DJ, Calamaras MR, DeVane CL, Donovan J, Beach AJ, Winn S, et al. Atypical antipsychotic administration during late pregnancy: Placental passage and obstetrical outcomes. Am J Psychiatry. 2007;164(8):1214–20.
DOI: 10.1176/appi.ajp.2007.06111886

Kris-Etherton PM, Petersen KS, Hibbeln JR, Hurley D, Kolick V, Peoples S, et al. Nutrition and behavioral health disorders: Depression and anxiety. Nutr Rev. 2021;79(3):247–60.
DOI: 10.1093/nutrit/nuaa025

Grosso G, Galvano F, Marventano S, Malaguarnera M, Bucolo C, Drago F, et al. Omega-3 fatty acids and depression: Scientific evidence and biological mechanisms. Oxid Med Cell Longev. 2014;2014.
DOI: 10.1155/2014/313570

Arksey H, O’Malley L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol. 2005;8(1):19–32.
DOI: 10.1080/1364557032000119616

Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. Ann Intern Med. 2018;169(7):467–73.
DOI: 10.7326/M18-0850

Urrútia G, Bonfill X. PRISMA declaration: A proposal to improve the publication of systematic reviews and meta-analyses. Med Clin (Barc). 2010;135(11):507–11.

Selva-Pareja L, Masot O. Guide and information manager to carry out your systematic review of the literature [Internet]. 2020 [cited 2021 Feb 13]. Available from: https://repositori.udl.cat/handle/10459.1/83797

Álvarez-Ramírez M, Lara MA, Cervantes-Alfaro JM, Robinson-Fuentes VA, Alveano-Hernández J. Correlation between intake of omega-3 fatty acids and depressive and anxiety symptoms during pregnancy. Salud Ment. 2018;41(1):31–8.
DOI: 10.17711/SM.0185-3325.2018.002

Pinto TJP, Vilela AAF, Farias DR, Lepsch J, Cunha GM, Vaz JS, et al. Serum n-3 polyunsaturated fatty acids are inversely associated with longitudinal changes in depressive symptoms during pregnancy. Epidemiol Psychiatr Sci. 2017;26(2):157–68.
DOI: 10.1017/S204579601500116X

Shiraishi M, Matsuzaki M, Yatsuki Y, Murayama R, Severinsson E, Haruna M. Associations of dietary intake and plasma concentrations of eicosapentaenoic and docosahexaenoic acid with prenatal depressive symptoms in Japan. Nurs Heal Sci. 2015;17(2):257–62.
DOI: 10.1111/nhs.12182

Chang JP, Lin CY, Lin PY, Shih YH, Chiu TH, Ho M, et al. Polyunsaturated fatty acids and inflammatory markers in major depressive episodes during pregnancy. Prog Neuropsychopharmacol Biol Psychiatry. 2018;80(Pt C):273–8.
DOI: 10.1016/j.pnpbp.2017.05.008

Sallis H, Steer C, Paternoster L, Davey Smith G, Evans J. Perinatal depression and omega-3 fatty acids: A Mendelian randomisation study. J Affect Disord. 2014;166:124–31.
DOI: 10.1016/j.jad.2014.04.077

Markhus MW, Skotheim S, Graff IE, Frøyland L, Braarud HC, Stormark KM, et al. Low Omega-3 Index in Pregnancy Is a Possible Biological Risk Factor for Postpartum Depression. PLoS One. 2013;8(7):e67617.
DOI: 10.1371/journal.pone.0067617

Farshbaf-Khalili A, Mohammad-Alizadeh S, Farshbaf-Khalili A, Mohammadi F, Ostadrahimi A. Fish-oil supplementation and maternal mental health: A triple-blind, randomized controlled trial. Iran Red Crescent Med J. 2017;19(1):e36237.
DOI: 10.5812/ircmj.36237

Judge MP, Beck CT, Durham H, McKelvey MM, Lammi-Keefe CJ. Pilot trial evaluating maternal docosahexaenoic acid consumption during pregnancy: Decreased postpartum depressive symptomatology. Int J Nurs Sci. 2014;1(4):339–45.
DOI: 10.1016/j.ijnss.2014.10.005

Mozurkewich EL, Clinton CM, Chilimigras JL, Hamilton SE, Allbaugh LJ, Berman DR, et al. The Mothers, Omega-3, and Mental Health Study: A double-blind, randomized controlled trial. Am J Obstet Gynecol. 2013;208(4):313.e1-313.e9.
DOI: 10.1016/j.ajog.2013.01.038

Cox JL, Holden JM, Sagovsky R. Detection of postnatal depression: development of the 10-item Edinburgh PostnatalDepression Scale. Br J Psychiatry. 1987;150:782–6
DOI: 10.1192/bjp.150.6.782

Urech C, Eussen SRBM, Alder J, Stahl B, Boehm G, Bitzer J, et al. Levels of n-3 and n-6 fatty acids in maternal erythrocytes during pregnancy and in human milk and its association with perinatal mental health. Nutrients. 2020;12(9):1–15.
DOI: 10.3390/nu12092773

Kobayashi M, Ogawa K, Morisaki N, Tani Y, Horikawa R, Fujiwara T. Dietary n-3 Polyunsaturated Fatty Acids in Late Pregnancy and Postpartum Depressive Symptom among Japanese Women. Front Psychiatry. 2017;8:241.
DOI: 10.3389/fpsyt.2017.00241

Makrides M, Gibson RA, McPhee AJ, Yell L, Quinlivan J, Ryan P, et al. Effect of DHA Supplementation During Pregnancy on Maternal Depression and Neurodevelopment of Young Children: A Randomized Controlled Trial. JAMA. 2010;304(15):1675–83.
DOI: 10.1001/jama.2010.1507

Opiyo RO, Nyasulu PS, Koigi RK, Obondo A, Ogoyi D, Kogi-Makau W. Effect of fish oil omega-3 fatty acids on reduction of depressive symptoms among HIV-seropositive pregnant women: a randomized, double-blind controlled trial. Ann Gen Psychiatry. 2018;17:49.
DOI: 10.1186/s12991-018-0220-4

Dos Santos Vaz J, Rodrigues Farias D, Rodrigues Amorim Adegboye A, Egidio Nardi A, Kac G. Omega-3 supplementation from pregnancy to postpartum to prevent depressive symptoms: a randomized placebocontrolled trial. BMC Pregnancy Childbirth. 2017;17(1):180.
DOI: 10.1186/s12884-017-1365-x

Herforth A, Arimond M, Álvarez-Sánchez C, Coates J, Christianson K, Muehlhoff E. A Global Review of Food-Based Dietary Guidelines. Adv Nutr. 2019;10(4):590–605.
DOI: 10.1093/advances/nmy130

Koletzko B, Cetin I, Thomas Brenna J. Consensus Statement Dietary fat intakes for pregnant and lactating women. Br J Nutr. 2007;98(5):873–7.
DOI: 10.1017/S0007114507764747

Sedgwick P, Greenwood N. Understanding the Hawthorne effect. BMJ. 2015;351:h4672.
DOI: 10.1136/bmj.h4672

Mezquida G, Fernández-Egea E, Treen D, Mané A, Bergé D, Savulich G, et al. Difficulties in delivery and depressive symptomatology in schizophrenia. Rev Psiquiatr Salud Ment. 2021;14(1):66–8.
DOI: 10.1016/j.rpsm.2019.12.002

Rees A, Sirois S, Wearden A. Maternal docosahexaenoic acid intake levels during pregnancy and infant performance on a novel object search task at 22 months. Child Dev. 2014;85(6):213–9.
DOI: 10.1111/cdev.12280

Lauritzen L, Brambilla P, Mazzocchi A, Harsløf LBS, Ciappolino V, Agostoni C. DHA effects in brain development and function. Nutrients. 2016;8(1):6.
DOI: 10.3390/nu8010006

Mozurkewich EL, Greenwood M, Clinton C, Berman D, Romero V, Djuric Z, et al. Pathway Markers for Pro-resolving Lipid Mediators in Maternal and Umbilical Cord Blood: A Secondary Analysis of the Mothers, Omega-3, and Mental Health Study. Front Pharmacol. 2016;7:274.
DOI: 10.3389/fphar.2016.00274

Radloff LS. The CES-D Scale: A self-report depression scale for research in general population. Appl Psychol Meas. 1977;1:385–401.
DOI: 10.1177/014662167700100306

Beck CT. Predictors of postpartum depression: an update. Nurs Res. 2003;50:275–85.
DOI: 10.1097/00006199-200109000-00004

Robertson E, Grace S, Wallington T, Stewart D. Antenatal risk factors for postpartum depression: a synthesis of recent literature. Gen Hosp Psych. 2004;26(4):289–95.
DOI: 10.1016/j.genhosppsych.2004.02.006

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