Nutrición Hospitalaria 02534 / http://dx.doi.org/10.20960/nh.02534
Resumen| PDF (ENGLISH)

Trabajo Original

Concentration of ghrelin and leptin in serum and human milk in nursing mothers according to the type of feeding


Alfredo Larrosa Haro, Edgar Manuel Vásquez-Garibay, Elizabeth Guzmán-Mercado, Nelly Carolina Muñoz-Esparza, Samuel García-Arellano, José Francisco Muñoz-Valle, Enrique Romero-Velarde

Prepublicado: 2019-07-08
Publicado: 2019-08-02

Logo Descargas   Número de descargas: 22160      Logo Visitas   Número de visitas: 6547      Citas   Citas: 2

Compártelo:


Objective: we assessed the relationship between serum and human foremilk and hindmilk concentrations of ghrelin and leptin in nursing mothers according to the type of feeding. Methods: this cohort design was carried out on 131 mother-newborn dyads admitted to a physiological puerperium ward. The independent variables were the type of feeding, full breastfeeding (FBF, 56.5%) and partial breastfeeding (PBF, 43.5%). The dependent variables were the concentration of total ghrelin (pg/ml) and leptin (ng/ml) in serum, foremilk and hindmilk at eight and 16 weeks. Fasting blood samples were obtained from the nursing mothers at four months for serum assays. Unpaired Student’s t-test, Mann-Whitney U test, Pearson’s correlation tests, coefficient of determination and linear regression were used. Results: the concentration of ghrelin and leptin in hindmilk was higher than that of foremilk in both groups at eight and 16 weeks. The concentration of ghrelin and leptin was higher in serum than in foremilk in both groups. These values showed a direct and significant linear correlation with the exception of ghrelin in the FBF group. The serum concentration of leptin in mothers explained 32% of the variance of its concentration in foremilk in the FBF and 13% in the PBF groups. Conclusion: the hindmilk/foremilk gradient suggests an intake regulating mechanism during the fed. The concentration of ghrelin and leptin was higher in the serum than in foremilk and its correlation and determination coefficients could suggest plasma-milk transfer in addition to synthesis regulation by the mammary gland, adipose tissue or other organs.

Palabras Clave: Human milk. Leptin. Ghrelin. Nursing mothers. Foremilk. Hindmilk.



Hunot-Alexander, Claudia, González-Toribio, Jocelyn, Vásquez-Garibay, Edgar Manuel, Larrosa-Haro, Alfredo, Casillas-Toral, Erika, Curiel-Curiel, Carmen Patricia (2021) Validity and Reliability of the Baby and Child Eating Behavior Questionnaire, Toddler Version (BEBQ-Mex and CEBQ-T-Mex) in a Low Sociodemographic Sample Recruited in a Mexican Hospital. Behavioral Sciences
Suwaydi, Majed A., Gridneva, Zoya, Perrella, Sharon L., Wlodek, Mary E., Lai, Ching Tat, Geddes, Donna T. (2021) Human Milk Metabolic Hormones: Analytical Methods and Current Understanding. International Journal of Molecular Sciences
WHO. Exclusive breastfeeding. e-Library of Evidence for Nutrition Actions (eLENA), 2016. [Cited June 4, 2016]. Available from http://www.who.int/elena/titles/exclusive_breastfeeding/en/
De Onis M, Garza C, Onyango AW, Borghi E. Comparison of the WHO child growth standards and the CDC 2000 growth charts. J Nutr 2007; 137:144-8.
DOI: 10.1093/jn/137.1.144
Victora CG, Horta BL, Loret de Mola C, Quevedo L, Pinheiro RT, Gigante DP, et al. Association between breastfeeding and intelligence, educational attainment, and income at 30 years of age: a prospective birth cohort study from Brazil. Lancet Glob Health 2015; 3:e199-e205.
DOI: 10.1016/S2214-109X(15)70002-1
Brown A, Lee M. Breastfeeding during the first year promotes satiety responsiveness in children aged 18-24 months. Pediatr Obes 2012; 7:382-90.
DOI: 10.1111/j.2047-6310.2012.00071.x
Park J, Kim HS, Chu SH, Jekal YS, Lee JY. The effect of predominant breast-feeding on the risk of obesity in Korean preschool children. Nurs Health Sci 2015; 17, 77–83.
DOI: 10.1111/nhs.12165
Li R, Magadia J, Fein SB, Grummer-Strawn LM. Risk of bottle-feeding for rapid weight gain during the first year of life. Arch Pediatr Adolesc Med 2012; 166:431-6.
DOI: 10.1001/archpediatrics.2011.1665
Petridou E, Mantzoros CS, Belechri M, Skalkidou A, Dessypris N, Papathoma E, et al. Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding. Clin Endocrinol (Oxf) 2005; 62:366-71.
DOI: 10.1111/j.1365-2265.2005.02225.x
Savino F, Liguori SA, Fissore MF, Palumeri E, Calabrese R, Oggero R, et al. Looking for a relation between serum leptin concentration and body composition parameters in healthy term infants in the first 6 months of life. J Pediatr Gastroenterol Nutr 2008; 46:348-51.
DOI: 10.1097/MPG.0b013e318159e6bf
Andreas NJ, Hyde MJ, Herbert BR, Jeffries S, Santhakumaran S, Mandalia S, et al. Impact of maternal BMI and sampling strategy on the concentration of leptin, insulin, ghrelin and resistin in breast milk across a single feed: a longitudinal cohort study. BMJ Open 2016;6: e010778.
DOI: 10.1136/bmjopen-2015-010778
Agostoni C. Ghrelin, leptin and the neurometabolic axis of breastfed and formula-fed infants. Acta Paediatr 2005; 94:523–5.
DOI: 10.1111/j.1651-2227.2005.tb01931.x
Schueler J, Alexander B, Hart AM, Austin K, Larson-Meyer DE. Presence and dynamics of leptin, GLP-1, and PYY in human breast milk at early postpartum. Obesity 2013; 21: 1451-58.
DOI: 10.1002/oby.20345
Karatas Z, Durmus Aydogdu S, Dinleyici EC, Colak O, Dogruel N. Breastmilk ghrelin, leptin, and fat levels changing foremilk to hindmilk: is that important for self-control of feeding? Eur J Pediatr 2011;170:1273–80.
DOI: 10.1007/s00431-011-1438-1
Marić G, Gazibara T, Zaletel I, Labudović Borović M, Tomanović N, Ćirić M, Puškaš N. The role of gut hormones in appetite regulation (review). Acta Physiol Hung 2014; 101:395-407.
DOI: 10.1556/APhysiol.101.2014.4.1
Münzberg H, Morrison CD. Structure, production and signaling of leptin. Metabolism 2015; 64:13-23.
DOI: 10.1016/j.metabol.2014.09.010
Breij LM, Mulder MT, van Vark-van der Zee LC, Hokken-Koelega AC. Appetite-regulating hormones in early life and relationships with type of feeding and body composition in healthy term infants. Eur J Nutr 2017; 56:1725-32.
DOI: 10.1007/s00394-016-1219-8
Larson-Meyer DE, Ravussin E, Heilbronn L, DeJonge L. Ghrelin and peptide YY in postpartum lactating and nonlactating women. Am J Clin Nutr 2010; 91: 366–72.
DOI: 10.3945/ajcn.2009.28616
Mizuno K, Nishida Y, Taki M, Murase M, Mukai Y, Itabashi K, et al. Is increased fat content of hindmilk due to the size or the number of milk fat globules? Int Breastfeed J 2009;4:7.
DOI: 10.1186/1746-4358-4-7
Smith-Kirwin SM, O’Connor DM, De Johnston J, Lancey ED, Hassink SG, Funanage, VL. Leptin expression in human mammary epithelial cells and breast milk. J. Clin Endocrinol Metab 1998, 83:1810-3.
DOI: 10.1210/jcem.83.5.4952
Bonnet M, Delavaud C, Laud K, Gourdou I, Leroux C, Djiane J. et al. Mammary leptin synthesis, milk leptin and their putative physiological roles. Reprod Nutr Dev 2002; 42:399-413. PMID: 12537253.
DOI: 10.1051/rnd:2002034
Cesur G, Ozguner F, Yilmaz N, Dundar B. The relationship between ghrelin and adiponectin levels in breast milk and infant serum and growth of infants during early postnatal life. J Physiol Sci 2012; 62:185-90.
DOI: 10.1007/s12576-012-0193-z
Savino F, Benetti S, Liguori SA, Sorrenti M, Cordero Di Montezemolo L. Advances on human milk hormones and protection against obesity. Cell Mol Biol 2013; 59:89-98.
Ilcol YO, Hizli B. Active and total ghrelin concentrations increase in breast milk during lactation. Acta Paediatr 2007; 96:1632–9.
DOI: 10.1111/j.1651-2227.2007.00493.x
Kierson JA, Dimatteo DM, Locke RG, Mackley AB, Spear ML. Ghrelin and cholecystokinin in term and preterm human breast milk. Acta Paediatr 2006, 95:991–5.
DOI: 10.1080/08035250600669769
Picó C, Oliver P, Sánchez J, Miralles O, Caimari A, Priego T et al. The intake of physiological doses of leptin during lactation in rats prevents obesity in later life. Int J Obes 2007; 31:1199-209.
DOI: 10.1038/sj.ijo.0803585
Stocker CJ, Cawthorne MA. The influence of leptin on early life programming of obesity. Trends Biotechnol 2008, 26:545-51.
DOI: 10.1016/j.tibtech.2008.06.004

Artículos Relacionados:

Trabajo Original: Efecto del tratamiento de dos días con orlistat sobre los niveles de leptina plasmática en pacientes obesas sin pérdida de peso

Ana Rodríguez-valle , María Ángeles Navarro-ferrando , Diana Boj-carceller , Jesús Fernando Escanero-marcén , Alejandro Sanz- Paris

Publicado: 2016-05-17 / http://dx.doi.org/10.20960/nh.106

Revisión: Beneficios inmunológicos de la leche humana para la madre y el niño. revisión sistemática

María José Aguilar Cordero , Laura Baena García , Antonio Manuel Sánchez López , Rafael Guisado Barrilao , Rafael Hermoso Rodríguez , Norma Mur Villar

Publicado: 2016-09-08 / http://dx.doi.org/10.20960/nh.526

Trabajo Original: Impacto de la pasteurización/liofilización en el contenido disponible de inmunoglobulinas en leche humana madura. estudio de aplicación en bancos de leche humana en hospitales

Jorge Castro Albarrán , Rosa Elena Navarro Hernández , Josué R. Solís Pacheco , Itza Carmina Salazar Quiñones , Griselda G. Macías López , Juan Carlos Barrera De León , Blanca Rosa Aguilar Uscanga

Publicado: 2016-10-03 / http://dx.doi.org/10.20960/nh.627

Trabajo Original: Beneficios a corto, medio y largo plazo de la ingesta de leche humana en recién nacidos de muy bajo peso

Bibiana Chinea Jiménez , Yumana Awad Parada , Antonio Villarino Marín , Miguel Sáenz de Pipaón

Publicado: 2017-02-01 / http://dx.doi.org/10.20960/nh.1014

Revisión: Appetite hormones in children and adolescents with cancer: a systematic review of observational studies

Ana Paula Trussardi Fayh , Agnes Denise de Lima Bezerra , Rogerio Friedman

Publicado: 2017-04-25 / http://dx.doi.org/10.20960/nh.1221

Trabajo Original: Anthropometric measure and adipokine levels of a young undergraduate population with a usual diet

Pedro Reyes-Castillo , Raquel González-Vázquez , Angélica Gutiérrez-Nava , Felipe Mendoza- Pérez , María del Carmen Navarro González , Alfonso Salgado-Sguayo , Edgard Torres-Maravilla , Lino Mayorga Reyes

Publicado: 2018-03-09 / http://dx.doi.org/10.20960/nh.1894

Trabajo Original: Influencia de la dieta de mujeres mexicanas sobre la calidad nutricional y la presencia de microorganismos benéficos en la leche humana

Jesús Alonso Amezcua López , Josué Raymundo Solís Pacheco , Elisa García Morales , José Alfonso Gutiérrez Padilla , Adelaida Sara Minia Zepeda Morales , Eusebio Angulo Castellanos , Miguel López Mincitar , Kelvin Fabricio Flores Arévalo , Ariana Rodríguez Arreola , Blanca Rosa Aguilar Uscanga

Publicado: 2018-12-21 / http://dx.doi.org/10.20960/nh.02477

Trabajo Original: Interdisciplinary therapy had positive effects on inflammatory state, mediated by leptin, adiponectin, and quality of diet in obese women

Carolina Kim Shiba , Ana Raimunda Dâmaso , Samantha Ottani Rhein , Paola Próspero Machado , Deborah Cristina Landi Masquio , Lila Missae Oyama , João Augusto Barreto Lombardi , Leonardo Lo Duca , Lian Tock , Gabriela Iervolino Oliveira , Raquel Munhoz da Silveira Campos

Publicado: 2019-07-08 / http://dx.doi.org/10.20960/nh.02777

Trabajo Original: Relationship of age at menarche and serum leptin with the metabolically unhealthy phenotype in adolescents

Ana Carla Leocadio de Magalhaes , Anna Paola Pierucci , Maria Núbia Oliveira , Aline Bull Ferrerira Campos , Patrícia Carvalho de Jesus

Publicado: 2020-02-18 / http://dx.doi.org/10.20960/nh.03050

Trabajo Original: Real-world study in infants fed with an infant formula with two human milk oligosaccharides

Enriqueta Román , José Manuel Moreno Villares , Francisco Domínguez Ortega , Alfonso Carmona Martínez , Leandro Picó Sirvent , Luz Santana Sandoval , Jose Casas Rivero , Ayham Alshweki , Colin Cercamondi , Samir Dahbane , Maria Luisa Vidal Guevara

Publicado: 2020-03-16 / http://dx.doi.org/10.20960/nh.03084

Trabajo Original: A prospective study in women: açaí (Euterpe oleracea Martius) dietary intake affects serum p-selectin, leptin, and visfatin levels

Melina Oliveira de Souza , Priscila Barbosa , Daniela Pala , Joana Ferreira Amaral , Ana Carolina Pinheiro Volp , Renata Nascimento de Freitas

Publicado: 2020-09-16 / http://dx.doi.org/10.20960/nh.03342

Trabajo Original: In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder

Ariana Rodríguez Arreola , Josué R. Solís Pacheco , Monique Lacroix , Edgar Balcazar López , Rosa Elena Navarro Hernández , Flavio Sandoval-Garcia , José Alfonso Gutiérrez Padilla , Elisa García Morales , Blanca Rosa Aguilar Uscanga

Publicado: 2020-09-07 / http://dx.doi.org/10.20960/nh.03335

Trabajo Original: Impacto de la pandemia por SARS-CoV-2 en un banco de leche humana

Patricia Miranda Romera , Manuela Peña Caballero , Estefanía Martín Álvarez , Laura Serrano López , José Antonio Hurtado Suazo

Publicado: 2021-01-22 / http://dx.doi.org/10.20960/nh.03535

Revisión: Efecto de la suplementación con omega-3 durante la gestación y la lactancia sobre la composición de ácidos grasos de la leche materna en los primeros meses de vida: una revisión narrativa

Daniza Puca , Pamela Estay Castillo , Carina Valenzuela , Yasna Muñoz

Publicado: 2020-12-18 / http://dx.doi.org/10.20960/nh.03486

Artículo Especial: Controversia actual sobre el papel crítico de los ácidos grasos poliinsaturados de cadena larga, araquidónico (ARA) y docosahexaenoico (DHA), en el lactante

Cristina Campoy , Aida Maribel Chisaguano Tonato , Andrea de la Garza Puentes , Miguel Sáenz de Pipaón , Elvira Verduci , Berthold Koletzko , Inés González Casanova , Elvira Larqué , Rodrigo Valenzuela , José Manuel Moreno Villares , Ángel Gil

Publicado: 2021-05-20 / http://dx.doi.org/10.20960/nh.03707

Revisión: Asociación entre tejido graso abdominal y riesgo de morbilidad: efectos positivos del ejercicio físico en la reducción de esta tendencia

Publicado: 2021-06-28 / http://dx.doi.org/

Trabajo Original: Estabilidad de la capacidad antioxidante y pH en leche humana refrigerada durante 72 horas: estudio longitudinal

Publicado: 2021-06-28 / http://dx.doi.org/

Trabajo Original: Parámetros hormonales e inflamatorios en un grupo de mujeres con sobrepeso/obesidad

Publicado: 2021-06-28 / http://dx.doi.org/

Trabajo Original: Estudio de los niveles séricos de leptina, ceruloplasmina y lipoproteína (a) como indicadores del riesgo cardiovascular en una población de adolescentes de Granada (España)

Publicado: 2021-06-30 / http://dx.doi.org/

Trabajo Original: Site-specific circadian expression of leptin and its receptor in human adipose tissue

Publicado: 2021-07-05 / http://dx.doi.org/

Trabajo Original: Increasing leptin level in abstaining alcohol-dependent women

Publicado: 2021-09-29 / http://dx.doi.org/

Trabajo Original: Leptin regulates gonadotropins and steroid receptors in the rats ovary

Publicado: 2021-10-19 / http://dx.doi.org/

Trabajo Original: Composition of breast milk of lactating adolescents in function of time of lactation

Publicado: 2021-10-29 / http://dx.doi.org/

Trabajo Original: Effects of human milk on blood and bone marrow cells in a malnourished mice model; comparative study with cow milk

Publicado: 2021-10-29 / http://dx.doi.org/

Trabajo Original: Effect of l-arginine supplementation on insulin resistance and adipocitokines levels in head and neck cancer non diabetic patients after surgery

Publicado: 2021-11-15 / http://dx.doi.org/

Trabajo Original: Reference values for leptin, cortisol, insulin and glucose, among European adolescents and their association with adiposity: The HELENA Study

Publicado: 2021-11-16 / http://dx.doi.org/

Trabajo Original: Time-specific changes in DNA methyltransferases associated with the leptin promoter during the development of obesity

Publicado: 2021-11-17 / http://dx.doi.org/

Trabajo Original: Asociación entre la conducta alimentaria y polimorfismos genéticos de la leptina y su receptor en niños obesos chilenos

Publicado: 2021-11-25 / http://dx.doi.org/

Trabajo Original: Are fat acids of human milk impacted by pasteurization and freezing?

Publicado: 2021-11-25 / http://dx.doi.org/

Trabajo Original: Comportamiento del eje entero-insular en una poblacion deportista; influencia de la dieta y el ejercicio

Publicado: 2021-11-30 / http://dx.doi.org/

Trabajo Original: Determination of cholesterol in human milk: an alternative to chromatographic methods

Publicado: 2022-01-19 / http://dx.doi.org/

Trabajo Original: Glucomannan and glucomannan plus spirulina-enriched squid-surimi added to high saturated diet affect glycemia, plasma and adipose leptin and adiponectin levels in growing fa/fa rats

Publicado: 2022-01-21 / http://dx.doi.org/

Trabajo Original: The leptin/adiponectin ratio as prognostic marker for dyslipidemia during 1 year of follow-up in pediatric patients receiving kidney replacement therapy

Miguel Ángel Villasís-Keever , Jessie Nallely Zurita-Cruz , Juana Serret-Montoya , Lourdes Barbosa-Cortés , Claudia del Carmen Zepeda-Martínez , Gabriela Alegría-Torres , Aly Sugei Barradas-Vázquez , Sara Alonso-Flores , Carolina Hernández-Hernández , Leticia Manuel-Apolinar , Leticia Damasio-Santana , Juan Manuel Domínguez-Salgado

Publicado: 2021-09-29 / http://dx.doi.org/10.20960/nh.03890

Trabajo Original: Influencia del perfil de las donantes en la bacteriología pre- y pospasteurización de la leche humana donada

Marta Padín Fontán , Montserrat Martín-Forero Maestre , Iván Rodríguez Otero , Cristina Durán Fernández-Feijoo , María Suárez Albo , Ana Concheiro Guisán

Publicado: 2021-12-27 / http://dx.doi.org/10.20960/nh.04014

Trabajo Original: Riesgo cardiovascular y resistencia insulínica en supervivientes de leucemia infantil

Aránzazu López Martínez , Marta Suárez González , Begoña Menéndez Llames , Pilar Palomo Moraleda , Soledad González Muñiz , Juan José Díaz Martín

Publicado: 2022-01-02 / http://dx.doi.org/10.20960/nh.04023

Revisión: Variación en el aporte de los biocomponentes inmunoglobulina A y lactoferrina en la leche humana después de la pasteurización Holder

Luis Alberto Bello Durán , Daniela Vanegas Otalvaro

Publicado: 2022-05-02 / http://dx.doi.org/10.20960/nh.04218

Trabajo Original: Dietary inflammatory index and its association with leptin and adiponectin in Uygur overweight/obese adults

Kaibinuer Zaibibuli , Dina Muheyati , Mei-Xia Lv , Guliqiekeran Aisike , Muhairemu Jielili , Jing Zhao , Ayinuer Aihemaiti , Jia Han

Publicado: 2022-06-10 / http://dx.doi.org/10.20960/nh.04281

Trabajo Original: Association of the leptin receptor rs 1805134 polymorphism with obesity parameters, dietary intakes, and metabolic syndrome in Caucasian obese subjects

Rocío Aller , David Primo Martín , Olatz Izaola , José Alfredo Martínez , Daniel de Luis Román

Publicado: 2022-04-01 / http://dx.doi.org/10.20960/nh.04139

Trabajo Original: Circulating leptin levels in the assessment of Crohn’s disease activity and its relation to nutritional status

Ying Zheng , Junlong Lin , Siqi Zhou , Shanying Liao , Yiming Fu , Yanjun Zhang , Xinbin Chen , Jinghong Li , Weihong Sha , Shixue Dai , Wenjun Ma

Publicado: 2022-12-12 / http://dx.doi.org/10.20960/nh.04572

Artículos más populares

Revisión: Ayuno intermitente: efectos en diversos escenarios clínicos

Introducción: los esquemas de ayuno intermitente (...

Publicado: 2023-05-24

Trabajo Original: Body mass index and risk of inflammatory breast disease: a Mendelian randomization study

Introduction: in previous studies, obesity was ide...

Publicado: 2023-04-22

Una cookie o galleta informática es un pequeño archivo de información que se guarda en su navegador cada vez que visita nuestra página web. La utilidad de las cookies es guardar el historial de su actividad en nuestra página web, de manera que, cuando la visite nuevamente, ésta pueda identificarle y configurar el contenido de la misma en base a sus hábitos de navegación, identidad y preferencias. Las cookies pueden ser aceptadas, rechazadas, bloqueadas y borradas, según desee. Ello podrá hacerlo mediante las opciones disponibles en la presente ventana o a través de la configuración de su navegador, según el caso. En caso de que rechace las cookies no podremos asegurarle el correcto funcionamiento de las distintas funcionalidades de nuestra página web. Más información en el apartado “POLÍTICA DE COOKIES” de nuestra página web.