Nutrición Hospitalaria 02534 / http://dx.doi.org/10.20960/nh.02534

Trabajo Original

Concentration of ghrelin and leptin in serum and human milk in nursing mothers according to the type of feeding

Alfredo Larrosa Haro, Edgar Manuel Vásquez-Garibay, Elizabeth Guzmán-Mercado, Nelly Carolina Muñoz-Esparza, Samuel García-Arellano, José Francisco Muñoz-Valle, Enrique Romero-Velarde

Prepublicado: 2019-07-08

Publicado: 2019-08-02

VOLUMEN 36, NÚM. 4, julio-agosto (2019), PAG. 799-804

Logo Descargas Número de descargas: 22234 Logo Visitas Número de visitas: 6834 Citas Citas: 0

Compártelo:

Objective: we assessed the relationship between serum and human foremilk and hindmilk concentrations of ghrelin and leptin in nursing mothers according to the type of feeding. Methods: this cohort design was carried out on 131 mother-newborn dyads admitted to a physiological puerperium ward. The independent variables were the type of feeding, full breastfeeding (FBF, 56.5%) and partial breastfeeding (PBF, 43.5%). The dependent variables were the concentration of total ghrelin (pg/ml) and leptin (ng/ml) in serum, foremilk and hindmilk at eight and 16 weeks. Fasting blood samples were obtained from the nursing mothers at four months for serum assays. Unpaired Student’s t-test, Mann-Whitney U test, Pearson’s correlation tests, coefficient of determination and linear regression were used. Results: the concentration of ghrelin and leptin in hindmilk was higher than that of foremilk in both groups at eight and 16 weeks. The concentration of ghrelin and leptin was higher in serum than in foremilk in both groups. These values showed a direct and significant linear correlation with the exception of ghrelin in the FBF group. The serum concentration of leptin in mothers explained 32% of the variance of its concentration in foremilk in the FBF and 13% in the PBF groups. Conclusion: the hindmilk/foremilk gradient suggests an intake regulating mechanism during the fed. The concentration of ghrelin and leptin was higher in the serum than in foremilk and its correlation and determination coefficients could suggest plasma-milk transfer in addition to synthesis regulation by the mammary gland, adipose tissue or other organs.

Palabras Clave: Human milk. Leptin. Ghrelin. Nursing mothers. Foremilk. Hindmilk.

Descargar PDF (ENGLISH)

Bibliografía
Artículos Relacionados

WHO. Exclusive breastfeeding. e-Library of Evidence for Nutrition Actions (eLENA), 2016. [Cited June 4, 2016]. Available from http://www.who.int/elena/titles/exclusive_breastfeeding/en/

De Onis M, Garza C, Onyango AW, Borghi E. Comparison of the WHO child growth standards and the CDC 2000 growth charts. J Nutr 2007; 137:144-8.
DOI: 10.1093/jn/137.1.144

Victora CG, Horta BL, Loret de Mola C, Quevedo L, Pinheiro RT, Gigante DP, et al. Association between breastfeeding and intelligence, educational attainment, and income at 30 years of age: a prospective birth cohort study from Brazil. Lancet Glob Health 2015; 3:e199-e205.
DOI: 10.1016/S2214-109X(15)70002-1

Brown A, Lee M. Breastfeeding during the first year promotes satiety responsiveness in children aged 18-24 months. Pediatr Obes 2012; 7:382-90.
DOI: 10.1111/j.2047-6310.2012.00071.x

Park J, Kim HS, Chu SH, Jekal YS, Lee JY. The effect of predominant breast-feeding on the risk of obesity in Korean preschool children. Nurs Health Sci 2015; 17, 77–83.
DOI: 10.1111/nhs.12165

Li R, Magadia J, Fein SB, Grummer-Strawn LM. Risk of bottle-feeding for rapid weight gain during the first year of life. Arch Pediatr Adolesc Med 2012; 166:431-6.
DOI: 10.1001/archpediatrics.2011.1665

Petridou E, Mantzoros CS, Belechri M, Skalkidou A, Dessypris N, Papathoma E, et al. Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding. Clin Endocrinol (Oxf) 2005; 62:366-71.
DOI: 10.1111/j.1365-2265.2005.02225.x

Savino F, Liguori SA, Fissore MF, Palumeri E, Calabrese R, Oggero R, et al. Looking for a relation between serum leptin concentration and body composition parameters in healthy term infants in the first 6 months of life. J Pediatr Gastroenterol Nutr 2008; 46:348-51.
DOI: 10.1097/MPG.0b013e318159e6bf

Andreas NJ, Hyde MJ, Herbert BR, Jeffries S, Santhakumaran S, Mandalia S, et al. Impact of maternal BMI and sampling strategy on the concentration of leptin, insulin, ghrelin and resistin in breast milk across a single feed: a longitudinal cohort study. BMJ Open 2016;6: e010778.
DOI: 10.1136/bmjopen-2015-010778

Agostoni C. Ghrelin, leptin and the neurometabolic axis of breastfed and formula-fed infants. Acta Paediatr 2005; 94:523–5.
DOI: 10.1111/j.1651-2227.2005.tb01931.x

Schueler J, Alexander B, Hart AM, Austin K, Larson-Meyer DE. Presence and dynamics of leptin, GLP-1, and PYY in human breast milk at early postpartum. Obesity 2013; 21: 1451-58.
DOI: 10.1002/oby.20345

Karatas Z, Durmus Aydogdu S, Dinleyici EC, Colak O, Dogruel N. Breastmilk ghrelin, leptin, and fat levels changing foremilk to hindmilk: is that important for self-control of feeding? Eur J Pediatr 2011;170:1273–80.
DOI: 10.1007/s00431-011-1438-1

Marić G, Gazibara T, Zaletel I, Labudović Borović M, Tomanović N, Ćirić M, Puškaš N. The role of gut hormones in appetite regulation (review). Acta Physiol Hung 2014; 101:395-407.
DOI: 10.1556/APhysiol.101.2014.4.1

Münzberg H, Morrison CD. Structure, production and signaling of leptin. Metabolism 2015; 64:13-23.
DOI: 10.1016/j.metabol.2014.09.010

Breij LM, Mulder MT, van Vark-van der Zee LC, Hokken-Koelega AC. Appetite-regulating hormones in early life and relationships with type of feeding and body composition in healthy term infants. Eur J Nutr 2017; 56:1725-32.
DOI: 10.1007/s00394-016-1219-8

Larson-Meyer DE, Ravussin E, Heilbronn L, DeJonge L. Ghrelin and peptide YY in postpartum lactating and nonlactating women. Am J Clin Nutr 2010; 91: 366–72.
DOI: 10.3945/ajcn.2009.28616

Mizuno K, Nishida Y, Taki M, Murase M, Mukai Y, Itabashi K, et al. Is increased fat content of hindmilk due to the size or the number of milk fat globules? Int Breastfeed J 2009;4:7.
DOI: 10.1186/1746-4358-4-7

Smith-Kirwin SM, O’Connor DM, De Johnston J, Lancey ED, Hassink SG, Funanage, VL. Leptin expression in human mammary epithelial cells and breast milk. J. Clin Endocrinol Metab 1998, 83:1810-3.
DOI: 10.1210/jcem.83.5.4952

Bonnet M, Delavaud C, Laud K, Gourdou I, Leroux C, Djiane J. et al. Mammary leptin synthesis, milk leptin and their putative physiological roles. Reprod Nutr Dev 2002; 42:399-413. PMID: 12537253.
DOI: 10.1051/rnd:2002034

Cesur G, Ozguner F, Yilmaz N, Dundar B. The relationship between ghrelin and adiponectin levels in breast milk and infant serum and growth of infants during early postnatal life. J Physiol Sci 2012; 62:185-90.
DOI: 10.1007/s12576-012-0193-z

Savino F, Benetti S, Liguori SA, Sorrenti M, Cordero Di Montezemolo L. Advances on human milk hormones and protection against obesity. Cell Mol Biol 2013; 59:89-98.

Ilcol YO, Hizli B. Active and total ghrelin concentrations increase in breast milk during lactation. Acta Paediatr 2007; 96:1632–9.
DOI: 10.1111/j.1651-2227.2007.00493.x

Kierson JA, Dimatteo DM, Locke RG, Mackley AB, Spear ML. Ghrelin and cholecystokinin in term and preterm human breast milk. Acta Paediatr 2006, 95:991–5.
DOI: 10.1080/08035250600669769

Picó C, Oliver P, Sánchez J, Miralles O, Caimari A, Priego T et al. The intake of physiological doses of leptin during lactation in rats prevents obesity in later life. Int J Obes 2007; 31:1199-209.
DOI: 10.1038/sj.ijo.0803585

Stocker CJ, Cawthorne MA. The influence of leptin on early life programming of obesity. Trends Biotechnol 2008, 26:545-51.
DOI: 10.1016/j.tibtech.2008.06.004

Artículos Relacionados:

Trabajo Original: Efecto del tratamiento de dos días con orlistat sobre los niveles de leptina plasmática en pacientes obesas sin pérdida de peso

Ana Rodríguez-valle , María Ángeles Navarro-ferrando , Diana Boj-carceller , Jesús Fernando Escanero-marcén , Alejandro Sanz- Paris

Trabajo Original

Concentration of ghrelin and leptin in serum and human milk in nursing mothers according to the type of feeding

Artículos Relacionados:

Trabajo Original: Efecto del tratamiento de dos días con orlistat sobre los niveles de leptina plasmática en pacientes obesas sin pérdida de peso

Revisión: Beneficios inmunológicos de la leche humana para la madre y el niño. revisión sistemática

Trabajo Original: Impacto de la pasteurización/lioﬁlización en el contenido disponible de inmunoglobulinas en leche humana madura. estudio de aplicación en bancos de leche humana en hospitales

Trabajo Original: Beneficios a corto, medio y largo plazo de la ingesta de leche humana en recién nacidos de muy bajo peso

Revisión: Appetite hormones in children and adolescents with cancer: a systematic review of observational studies

Trabajo Original: Anthropometric measure and adipokine levels of a young undergraduate population with a usual diet

Trabajo Original: Influencia de la dieta de mujeres mexicanas sobre la calidad nutricional y la presencia de microorganismos benéficos en la leche humana

Trabajo Original: Interdisciplinary therapy had positive effects on inflammatory state, mediated by leptin, adiponectin, and quality of diet in obese women

Trabajo Original: Relationship of age at menarche and serum leptin with the metabolically unhealthy phenotype in adolescents

Trabajo Original: Real-world study in infants fed with an infant formula with two human milk oligosaccharides

Trabajo Original: A prospective study in women: açaí (Euterpe oleracea Martius) dietary intake affects serum p-selectin, leptin, and visfatin levels

Trabajo Original: In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder

Trabajo Original: Impacto de la pandemia por SARS-CoV-2 en un banco de leche humana

Revisión: Efecto de la suplementación con omega-3 durante la gestación y la lactancia sobre la composición de ácidos grasos de la leche materna en los primeros meses de vida: una revisión narrativa

Artículo Especial: Controversia actual sobre el papel crítico de los ácidos grasos poliinsaturados de cadena larga, araquidónico (ARA) y docosahexaenoico (DHA), en el lactante

Revisión: Asociación entre tejido graso abdominal y riesgo de morbilidad: efectos positivos del ejercicio físico en la reducción de esta tendencia

Trabajo Original: Estabilidad de la capacidad antioxidante y pH en leche humana refrigerada durante 72 horas: estudio longitudinal

Trabajo Original: Parámetros hormonales e inflamatorios en un grupo de mujeres con sobrepeso/obesidad

Trabajo Original: Estudio de los niveles séricos de leptina, ceruloplasmina y lipoproteína (a) como indicadores del riesgo cardiovascular en una población de adolescentes de Granada (España)

Trabajo Original: Site-specific circadian expression of leptin and its receptor in human adipose tissue

Trabajo Original: Increasing leptin level in abstaining alcohol-dependent women

Trabajo Original: Leptin regulates gonadotropins and steroid receptors in the rats ovary

Trabajo Original: Composition of breast milk of lactating adolescents in function of time of lactation

Trabajo Original: Effects of human milk on blood and bone marrow cells in a malnourished mice model; comparative study with cow milk

Trabajo Original: Effect of l-arginine supplementation on insulin resistance and adipocitokines levels in head and neck cancer non diabetic patients after surgery

Trabajo Original: Reference values for leptin, cortisol, insulin and glucose, among European adolescents and their association with adiposity: The HELENA Study

Trabajo Original: Time-specific changes in DNA methyltransferases associated with the leptin promoter during the development of obesity

Trabajo Original: Asociación entre la conducta alimentaria y polimorfismos genéticos de la leptina y su receptor en niños obesos chilenos

Trabajo Original: Are fat acids of human milk impacted by pasteurization and freezing?

Trabajo Original: Comportamiento del eje entero-insular en una poblacion deportista; influencia de la dieta y el ejercicio

Trabajo Original: Determination of cholesterol in human milk: an alternative to chromatographic methods

Trabajo Original: Glucomannan and glucomannan plus spirulina-enriched squid-surimi added to high saturated diet affect glycemia, plasma and adipose leptin and adiponectin levels in growing fa/fa rats

Trabajo Original: The leptin/adiponectin ratio as prognostic marker for dyslipidemia during 1 year of follow-up in pediatric patients receiving kidney replacement therapy

Trabajo Original: Influencia del perfil de las donantes en la bacteriología pre- y pospasteurización de la leche humana donada

Trabajo Original: Riesgo cardiovascular y resistencia insulínica en supervivientes de leucemia infantil

Revisión: Variación en el aporte de los biocomponentes inmunoglobulina A y lactoferrina en la leche humana después de la pasteurización Holder

Trabajo Original: Dietary inflammatory index and its association with leptin and adiponectin in Uygur overweight/obese adults

Trabajo Original: Association of the leptin receptor rs 1805134 polymorphism with obesity parameters, dietary intakes, and metabolic syndrome in Caucasian obese subjects

Trabajo Original: Circulating leptin levels in the assessment of Crohn’s disease activity and its relation to nutritional status

Trabajo Original: Efectos del zinc y resveratrol como moduladores de la respuesta a la leptina en adultos con obesidad

Artículos más populares

Revisión: La importancia de la alimentación en la prevención de la endometriosis: revisión sistemática

Artículo Especial: Componentes bioactivos del grano integral y su efecto en la salud