Nutrición Hospitalaria 04435 / http://dx.doi.org/10.20960/nh.04435

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Trabajo Original

Association of the triglyceride-glucose index with the occurrence of non-alcoholic fatty liver disease and mortality in elderly inpatients: a prospective observational study

Xiaogang Wang, Wei Zhou, Qianqian Song, Ying Xie

Prepublicado: 2023-02-15

Publicado: 2023-04-10

VOLUMEN 40, NÚM. 2, marzo-abril (2023), PAG. 319-324

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Introduction: non-alcoholic fatty liver disease (NAFLD) is a disease in which there is excessive fat deposition in hepatocytes due to hepatoprotective factors. Objectives: to assess the association of the triglyceride-glucose index with the occurrence of non-alcoholic fatty liver disease and mortality in elderly inpatients. To identify the TyG index as a predictive factor of NAFLD. Methods: this prospective observational study included elderly inpatients admitted to the Department of Endocrinology at the Linyi Geriatrics Hospital, Affiliated to Shandong Medical College, between August 2020 and April 2021. The TyG index was calculated according to an established formula: TyG = Ln [triglycerides (TG) (mg/dl) × Fasting plasma glucose (FPG) (mg/dl) / 2]. Result: a total of 264 patients were enrolled, with 52 (19.7 %) cases occurred NAFLD. Multivariate logistic regression analysis showed that TyG (OR = 3.889; 95 % CI: 1.134-11.420; p = 0.014) and ALT (OR = 1.064; 95 % CI: 1.012-1.118; p = 0.015) were independently associated with the occurrence of NAFLD. Furthermore, receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of TyG was 0.727, with sensitivity = 80.4 % and specificity = 57.8 % at cut off = 8.71. A Cox proportional hazards regression model showed that, after adjusting for age, sex, smoking, drinking, hypertension, and type 2 diabetes, TyG > 8.71 (HR = 3.191; 95 % CI: 1.347 to 7.560; p < 0.001) was an independent risk factor for mortality in the elderly. Conclusions: the TyG index can predict non-alcoholic fatty liver disease and mortality in elderly Chinese inpatients.

Palabras Clave: Triglyceride-glucose index. Occurrence. Non-alcoholic fatty liver disease. Mortality. Prospective observational study.

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Artículos Relacionados

Abdelmalek MF. Nonalcoholic fatty liver disease: another leap forward. Nat Rev Gastroenterol Hepatol. 2021;18(2):85-6.
DOI: 10.1038/s41575-020-00406-0

Cotter TG, Rinella M. Nonalcoholic Fatty Liver Disease 2020: The State of the Disease. Gastroenterology. 2020;158(7):1851-64.
DOI: 10.1053/j.gastro.2020.01.052

Ferro D, Baratta F, Pastori D, Cocomello N, Colantoni A, Angelico F, et al. New Insights into the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Gut-Derived Lipopolysaccharides and Oxidative Stress. Nutrients. 2020;12(9).
DOI: 10.3390/nu12092762

Long MT, Wang N, Larson MG, Mitchell GF, Palmisano J, Vasan RS, et al. Nonalcoholic fatty liver disease and vascular function: cross-sectional analysis in the Framingham heart study. Arterioscler Thromb Vasc Biol. 2015;35(5):1284-91.
DOI: 10.1161/ATVBAHA.114.305200

Ipsen DH, Lykkesfeldt J, Tveden-Nyborg P. Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease. Cell Mol Life Sci. 2018;75(18):3313-27.
DOI: 10.1007/s00018-018-2860-6

Hagström H, Nasr P, Ekstedt M, Kechagias S, Stål P, Bedossa P, et al. SAF score and mortality in NAFLD after up to 41 years of follow-up. Scand J Gastroenterol. 2017;52(1):87-91.
DOI: 10.1080/00365521.2016.1230779

Hill MA, Yang Y, Zhang L, Sun Z, Jia G, Parrish AR, et al. Insulin resistance, cardiovascular stiffening and cardiovascular disease. Metabolism. 2021;119:154766.
DOI: 10.1016/j.metabol.2021.154766

Onyango AN. Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance. Oxid Med Cell Longev. 2018;2018:4321714.
DOI: 10.1155/2018/4321714

Lindenmeyer CC, McCullough AJ. The Natural History of Nonalcoholic Fatty Liver Disease-An Evolving View. Clin Liver Dis. 2018;22(1):11-21.
DOI: 10.1016/j.cld.2017.08.003

Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, et al. Animal models of obesity and diabetes mellitus. Nat Rev Endocrinol. 2018;14(3):140-62.
DOI: 10.1038/nrendo.2017.161

Gambino R, Bugianesi E, Rosso C, Mezzabotta L, Pinach S, Alemanno N, et al. Different Serum Free Fatty Acid Profiles in NAFLD Subjects and Healthy Controls after Oral Fat Load. Int J Mol Sci. 2016;17(4):479.
DOI: 10.3390/ijms17040479

Hong SH, Choi KM. Sarcopenic Obesity, Insulin Resistance, and Their Implications in Cardiovascular and Metabolic Consequences. Int J Mol Sci. 2020;21(2).
DOI: 10.3390/ijms21020494

Huang JF, Tsai PC, Yeh ML, Huang CF, Huang CI, Hsieh MH, et al. Risk stratification of non-alcoholic fatty liver disease across body mass index in a community basis. J Formos Med Assoc. 2020;119(1 Pt 1):89-96.
DOI: 10.1016/j.jfma.2019.03.014

Enooku K, Kondo M, Fujiwara N, Sasako T, Shibahara J, Kado A, et al. Hepatic IRS1 and ß-catenin expression is associated with histological progression and overt diabetes emergence in NAFLD patients. J Gastroenterol. 2018;53(12):1261-75.
DOI: 10.1007/s00535-018-1472-0

Sheka AC, Adeyi O, Thompson J, Hameed B, Crawford PA, Ikramuddin S. Nonalcoholic Steatohepatitis: A Review. Jama. 2020;323(12):1175-83.
DOI: 10.1001/jama.2020.2298

Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 2018;15(1):11-20.
DOI: 10.1038/nrgastro.2017.109

Younossi ZM, Golabi P, de Avila L, Paik JM, Srishord M, Fukui N, et al. The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis. J Hepatol. 2019;71(4):793-801.
DOI: 10.1016/j.jhep.2019.06.021

Park K, Ahn CW, Lee SB, Kang S, Nam JS, Lee BK, et al. Elevated TyG Index Predicts Progression of Coronary Artery Calcification. Diabetes Care. 2019;42(8):1569-73.
DOI: 10.2337/dc18-1920

Liu XC, He GD, Lo K, Huang YQ, Feng YQ. The Triglyceride-Glucose Index, an Insulin Resistance Marker, Was Non-linear Associated With All-Cause and Cardiovascular Mortality in the General Population. Front Cardiovasc Med. 2020;7:628109.
DOI: 10.3389/fcvm.2020.628109

Sanyal AJ. Past, present and future perspectives in nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 2019;16(6):377-86.
DOI: 10.1038/s41575-019-0144-8

Mohd Nor NS, Lee S, Bacha F, Tfayli H, Arslanian S. Triglyceride glucose index as a surrogate measure of insulin sensitivity in obese adolescents with normoglycemia, prediabetes, and type 2 diabetes mellitus: comparison with the hyperinsulinemic-euglycemic clamp. Pediatr Diabetes. 2016;17(6):458-65.
DOI: 10.1111/pedi.12303

Kitae A, Hashimoto Y, Hamaguchi M, Obora A, Kojima T, Fukui M. The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study. Can J Gastroenterol Hepatol. 2019;2019:5121574.
DOI: 10.1155/2019/5121574

Farrell GC, Chitturi S, Lau GK, Sollano JD. Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary. J Gastroenterol Hepatol. 2007;22(6):775-7.
DOI: 10.1111/j.1440-1746.2007.05002.x

Sung KC, Lee MY, Lee JY, Lee SH, Kim YB, Song WJ, et al. Natural course of fatty liver in 36,195 South Korean adults. Sci Rep. 2019;9(1):9062.
DOI: 10.1038/s41598-019-44738-7

Lee SB, Ahn CW, Lee BK, Kang S, Nam JS, You JH, et al. Association between triglyceride glucose index and arterial stiffness in Korean adults. Cardiovasc Diabetol. 2018;17(1):41.
DOI: 10.1186/s12933-018-0692-1

Kato K, Takeshita Y, Misu H, Zen Y, Kaneko S, Takamura T. Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in Japanese patients with non-alcoholic fatty liver disease. J Diabetes Investig. 2015;6(2):158-63.
DOI: 10.1111/jdi.12271

Zhang S, Du T, Zhang J, Lu H, Lin X, Xie J, et al. The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease. Lipids Health Dis. 2017;16(1):15.
DOI: 10.1186/s12944-017-0409-6

Huanan C, Sangsang L, Amoah AN, Yacong B, Xuejiao C, Zhan S, et al. Relationship between triglyceride glucose index and the incidence of non-alcoholic fatty liver disease in the elderly: a retrospective cohort study in China. BMJ Open. 2020;10(11):e039804.
DOI: 10.1136/bmjopen-2020-039804

Simental-Mendía LE, Simental-Mendía E, Rodríguez-Hernández H, Rodríguez-Morán M, Guerrero-Romero F. The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women. Ann Hepatol. 2016;15(5):715-20.

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