Hillary Kimberly Osorio Landa, Iván Pérez Díaz, Sara del Carmen Laguna Bárcenas, Juan Manuel López Navarro, María Fernanda Abella Roa, Mariel Corral Orozco, Juan Pablo Mancilla Ortega, Diana Alheli Martínez Duarte, Susana Isabel Morales Montalvo, Sebastián Múzquiz Aguirre, Elizabet Sánchez Landa
Número de descargas:
13452
Número de visitas:
3100
Compártelo:
Introduction: whether hypovitaminosis D is an overarching cause of increased mortality or a prognostic marker of poor health has not been well elucidated. Objectives: we sought to determine the association of serum 25-hydroxyvitamin D [25-(OH)-D3] levels with the clinical biochemical parameters and mortality risk in chronic diseases. Methods: we reviewed the clinical charts and collected the clinical biochemical parameters of patients diagnosed with chronic conditions who had at least one 25-(OH)-D3 determination, with or without calcium and vitamin D supplementation, and who were selected using a cluster random sampling design (n = 1,705). The analysis was focused on metabolic disorders (type-2 diabetes mellitus [T2DM] and obesity), autoimmune disorders, and mortality. Multivariate logistic regression analyses were performed. Results: low 25-(OH)-D3 levels were reported in 1,433 (84.0%) patients, of which 774 (45.4%) had insufficiency (20-29 ng/mL) and 659 (38.6%) patients had deficiency (< 20 ng/mL). Lower 25-(OH)-D3 levels in T2DM patients were associated with higher glycosylated hemoglobin levels (p < 0.001). Patients with 25-(OH)-D3 levels < 12.5 ng/mL had a higher mortality risk than those with levels ≥ 12.5 ng/mL (HR: 3.339; 95% CI: 1.342-8.308). We observed lower 25-(OH)-D3 levels in patients with grade-III obesity (p = 0.01). We found a higher risk of 25-(OH)-D3 deficiency in rheumatoid arthritis, type-1 diabetes, and systemic lupus erythematosus (p = 0.032, p = 0.002, p = 0.049, respectively). Conclusions: we found a significant relationship between 25-(OH)-D3 levels and glycemic control, body mass index, autoimmune disease, and mortality risk. Nevertheless, whether hypovitaminosis D plays a causal role or is a consequence of chronic disease remains controversial.
Palabras Clave: Vitamin D. Glycemic control. Type-2 diabetes mellitus. Autoimmune disease. Mortality.
Ana Obispo Entrenas , Francisco Martín Carvajal , David Legupín Tubío , Fabiola Lucena Navarro , Manuel García Caballero , Norberto Gándara Adán , Jimena Abilés Osinaga
Fátima Martínez-Lozano Aranaga , Paula Palacios Vales , Juana María Serrano Navarro , Carmen Caballero Requejo , María Jesús Gómez Ramos , Carmen Sánchez Álvarez
Candelaria Martín-González , Ana María Torres-Vega , Emilio González-Reimers , Geraldine Quintero-platt , Camino Fernández-rodríguez , Julio Alvisa-negrín , Adnan Hawari-meilud , Francisco Santolaria-fernández
Juan Emmanuel Pérez-flores , Mariana Chávez Tostado , Youné Elizabeth Larios-del-toro , Jesús García-rentería , Jorge Rendrón-félix , Marcela Salazar-parra , Leire Irusteta-jiménez , Luis Rodrigo Michel-espinoza , Aída Rebeca Márquez-valdez , Lisbeth Cuesta-márquez , Andrea Socorro Álvarez-villaseñor , Clotilde Fuentes-orozco , Alejandro González Ojeda
Francisco Javier Valero Chávez , Luis Miguel Luengo Pérez , Javier Cubero Juánez
Cristina Casals-vázquez , Ernesto Suárez-cadenas , Francisca María Estébanez Carvajal , María Pilar Aguilar Trujillo , María M. Jiménez Arcos , María Ángeles Vázquez Sáchez
Juan Luis Bonilla Palomas , Antonio Luis Gámez López , Mirian Moreno Conde , María Cristina López Ibáñez , Patricia Castellano García , Carlos Javier Ráez Ruiz , Rocío Ruíz Quirós , Esmeralda Ramiro Ortega
Irene Ródenas Esteve , Carmina Wanden-berghe , Javier Sanz-Valero
Inés Martínez Redondo , Ruth García Romero , Pilar Calmarza , Antonio De Arriba Muñoz , Gerardo Rodríguez , José Ignacio Labarta Aizpun
Cristina Casals , José Luis Casals Sánchez , Ernesto Suárez Cadenas , María Pilar Aguilar-trujillo , Francisca María Estébanez Carvajal , María Ángeles Vázquez-sánchez
Pilar Calmarza , Alejandro Sanz Paris , Carlos Prieto López , Mónica Llorente Barrio , Diana Boj Carceller
Dayana Joyce Marques Queiroz , Alexandre Sérgio Silva , Alcides da Silva Diniz , Alice Teles de Carvalho , Eduarda Pontes dos Santos Araújo , Juliana Padilha Ramos Neves , Lavoisiana Mateus de Lacerda , Lydiane Tavares Toscano , Maria da Conceição Rodrigues Gonçalves
Laura Redondo Robles , Begoña Pintor de la Maza , Javier Tejada García , Juan José García Vieitez , María José Fernández Gómez , Inmaculada Barrera Mellado , María Dolores Ballesteros Pomar
Gonçalo Nunes , Mariana Brito , Marta Patita , Carla Adriana Santos , Jorge Fonseca
Citlalli Álvarez Zaragoza , Edgar Manuel Vásquez-Garibay , Andrea Anaís García Contreras , Alfredo Larrosa Haro , Enrique Romero Velarde , Alejandro Rea Rosas , José Luis Cabrales de Anda , Israel Francisco Vega Olea
Laura M. Bermejo , Carmen Gómez-Candela , Sergio Dahdouh , Bricia López-plaza
Alejandro Martínez , Gaspar Ros , Gema Nieto
Marcelo Campos Appel-da-Silva , Priccila Zuchinali , Rogério Fleck de Oliveira , Caroline Schardong Boligon , Caroline Riella , Gabriela Soranço Salazar
Carlos H. Orces
Albert Salas-Huetos , Maria Dolores Huetos-Solano , Jordi Salas Salvadó
Jesús R. Huertas , Avilene Rodríguez Lara , Olivia González Acevedo , María Dolores Mesa-García
Héctor Vázquez-Lorente , Lourdes Herrera-Quintana , Bartolomé Quintero-Osso , Jorge Molina-lópez , Elena Planells
Nayra do Socorro Caldas Carvalho de Almeida Teixeira , Beatriz de Mello Pereira , Iara Katrynne Fonsêca Oliveira , Carlos Henrique Ribeiro Lima , Cecília Maria Resende Gonçalves de Carvalho , Ivone Freires de Oliveira Costa Nunes , Dorcas Lamounier Costa , Adriana de Azevedo Paiva
Giovanna Inostroza Flores , Giovanni Francino Barrera , Sergio Jiménez Torres
Elena Rodríguez-Rodríguez , Aránzazu Aparicio , Patricia Sánchez-Rodríguez , Ana M. Lorenzo Mora , Ana María López-Sobaler , Rosa M.ª Ortega
Juliana Padilha Ramos Neves , Dayana Joyce Marques Queiroz , Eduarda Pontes dos Santos Araújo , Lavoisiana Mateus de Lacerda , Rayner Anderson Ferreira do Nascimento , Alice Teles de Carvalho , Maria José de Carvalho Costa , Ana Karina Teixeira da Cunha França , Darlene Camati Persuhn , Alexandre Sérgio Silva , Alcides da Silva Diniz , Maria da Conceição Rodrigues Gonçalves
Alejandra Mora Mendoza , Francisca Pereyra-García Castro , José Gregorio Oliva García , José Pablo Suárez Llanos , Antonio Medina Rodriguez , Nieves Caracena Castellanos , María Aracelí García Nuñez , José Enrique Palacio Abizanda
Carlos H. Orces , Enrique López Gavilánez
Irene Carrillo González , María José Martínez-Ramírez , Carmen Tenorio Jiménez , Alberto Damián Delgado Martínez , Rosario Aguilar Peña , Rosa Madrigal Cueto , Miguel Delgado-Rodríguez
Daniel de Luis , Emilia Gómez Hoyos , Ana Ortolá Buigues , Esther Delgado , Gonzalo Díaz , Beatriz Torres Torres , Juan José López Gómez
Amanda Ribamar , Beatriz Almeida , Andressa Soares , Beatriz Peniche , Patrícia Jesus , Sabrina Pereira da Cruz , Andréa Ramalho
Irene de la Calle , Gaspar Ros , Rocío Peñalver Miras , Gema Nieto
Renata Ferreira Silva , Maria Rita Carvalho Garbi Novaes , Dirce Bellezi Guilhem
José Manuel Quesada Gómez , Alfonso Calañas Continente
Sheila Alejandra Campos León , Agustín Ramiro Urzua González , Manuel José Rivera Chávez , María de Lourdes Reyes Escogido , Jaime Rivera Morales , Rodolfo Guardado-Mendoza
Natalia García-Vazquez , Samara Palma Milla , Bricia López-Plaza , Marlhyn Valero-Pérez , Marina Morato-Martínez , Carmen Gómez-Candela
Carlos H. Orces
Fernando Macaya , Carolina Espejo Paeres , Adrián Valls , Antonio Fernández-Ortiz , Juan González del Castillo , F. Javier Martín-Sánchez , Isabelle Runkle , Miguel Ángel Rubio Herrera
Rosa M.ª Ortega , Ana Isabel Jiménez Ortega , Rosa María Martínez García , Esther Cuadrado Soto , Aránzazu Aparicio , Ana María López-Sobaler
Carlos Henrique Ribeiro Lima , Layanne Cristina de Carvalho Lavôr Layanne , Nadir do Nascimento Nogueira , Gilmara Péres Rodrigues , Karoline de Macêdo Gonçalves Frota , Nayra do Socorro Caldas Carvalho de Almeida Teixeira , Iara Katrynne Fonsêca Oliveira , Adriana de Azevedo Paiva
Raquel Costa Silva Dantas-Komatsu , Fernanda Lambert de Andrade Freire , Niethia Regina Dantas de Lira , Rosiane Viana Zuza Diniz , Severina Carla Vieira Cunha Lima , Lucia Fatima Campos Pedrosa , Karine Cavalcanti Maurício Sena-Evangelista
Introducción: la malnutrición es un problema médic...
La anorexia nerviosa es la enfermedad psiquiátrica...