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Trabajo Original

Oxidative and inflammatory effects of pulmonary rehabilitation in patients with bronchiectasis. A prospective, randomized study

Casilda Olveira, Eva García-Escobar, Esperanza Doña, Francisco J. Palenque, Nuria Porras, Antonio Dorado, Ana María Godoy, Elezahara Rubio-Martín, Francisco-Javier Bermúdez-Silva, Silvana Y. Romero-Zerbo, Gemma Rojo Martínez, Rocío Martín-Valero, José Abuín Fernández, Gabriel Olveira

Prepublicado: 2020-01-21
Publicado: 2020-02-12
VOLUMEN 37, NÚM. 1, enero-febrero (2020), PAG. 6-13

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Compártelo:


Background: systemic inflammation and oxidative stress are important factors in the pathogenesis of bronchiectasis. Pulmonary rehabilitation (PR) is recommended for bronchiectasis, but there is no data about its effect on the inflammatory and REDOX status of these patients. Aims: to investigate the effect of PR in non-cystic-fibrosis bronchiectasis (NCFB) patients, and to compare it with the effect of PR plus a hyperproteic oral nutritional supplement (PRS) enriched with beta-hydroxy-beta-methylbutyrate (HMB) on serum inflammatory and oxidative biomarkers. Materials and methods: this was an open randomized, controlled trial. Thirty individuals (65 years old or younger with a body mass index over 18.5, older than 65 years with a body mass index over 20) were recruited from September 2013 to September 2014, and randomly assigned to receive PR or PRS. Total neutrophils, and inflammatory and oxidative biomarker levels were measured at baseline, and then at 3 and 6 months. Results: in the PRS group neutrophil levels were decreased from baseline at 6 months. A significantly different fold change was found between the PR and PRS groups. In the PR group, IL-6 and adiponectin were increased by the end of the study while TNFα levels were decreased from baseline at 6 months. REDOX biomarkers remained stable throughout the study except for 8-isoprostane levels, which were increased from baseline at 6 months in both groups of patients. Conclusions: a PR program induced a pro-oxidative effect accompanied by changes in circulating inflammatory cytokine levels in NCFB patients. Our results would also suggest a possible beneficial effect of the HMB enriched supplement on neutrophil level regulation in these patients. The information provided in this study could be useful for choosing the right therapeutic approach in the management of bronchiectasis.

Palabras Clave: Bronchiectasis. Pulmonary rehabilitation. HMB (beta-hydroxy-beta-methylbutyrate). Oxidative stress. Cytokines.



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Resumen | PDF

Trabajo Original: Effect of l-arginine supplementation on insulin resistance and adipocitokines levels in head and neck cancer non diabetic patients after surgery

Publicado: 2021-11-15 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program

Publicado: 2021-11-15 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Indicadores de estrés oxidativo en suero y comportamiento alimentario en adultos de una zona rural de Jalisco, México

Publicado: 2021-11-18 / http://dx.doi.org/
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Trabajo Original: Effects of dietary supplementation with lemon verbena extracts on serum inflammatory markers of multiple sclerosis patients

Publicado: 2021-11-24 / http://dx.doi.org/
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Trabajo Original: High-protein diet induces oxidative stress in rat brain: protective action of high-intensity exercise against lipid peroxidation

Publicado: 2021-11-25 / http://dx.doi.org/
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Trabajo Original: Glycemic Control and Oxidative Stress Markers and their relationship with the Thioredoxin Interacting Protein (TXNIP) gene in Type 2 Diabetic patients

Publicado: 2021-11-25 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Factores que inciden el daño oxidativo en niños con obesidad: estudio piloto

Publicado: 2021-11-26 / http://dx.doi.org/
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Trabajo Original: Purine nucleoside phosphorylase and the enzymatic antioxidant defense system in breast milk from women with different levels of arsenic exposure

Publicado: 2021-11-30 / http://dx.doi.org/
Resumen | PDF

Revisión: Inflamación y obesidad (lipoinflamación)

Publicado: 2021-11-30 / http://dx.doi.org/
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Trabajo Original: Reduction of serum advanced glycation end-products with a low calorie Mediterranean diet

Publicado: 2021-11-30 / http://dx.doi.org/
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Trabajo Original: Fish oil and vitamin E change lipid profiles and anti-LDL-antibodies in two different ethnic groups of women transitioning through menopause

Publicado: 2021-12-01 / http://dx.doi.org/
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Trabajo Original: Effect of long term intake of white tea on acute oxidative stress in rats

Publicado: 2022-01-11 / http://dx.doi.org/
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Trabajo Original: Relationship between zincemia, superoxide dismutase activity and marker of oxidative stress in women with breast cancer

Publicado: 2022-01-12 / http://dx.doi.org/
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Trabajo Original: Macronutrient intake is correlated with dyslipidemia and low-grade inflammation in childhood obesity but mostly in male obese

Publicado: 2022-01-12 / http://dx.doi.org/
Resumen | PDF

Revisión: Potencial antioxidante de la miel de Melipona beecheii y su relación con la salud: una revisión

Publicado: 2022-01-19 / http://dx.doi.org/
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Trabajo Original: Glutathione peroxidase-1 Pro200Leu polymorphism (rs1050450) is associated with morbid obesity independently of the presence of prediabetes or diabetes in women from Central Mexico

Publicado: 2022-01-19 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Epitope-based vaccine for the treatment of Der f 3 allergy

Publicado: 2022-01-21 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Dietary fish oil increases catalase activity in patients with probable Alzheimer’s disease

Blanca M. G. Torres-Mendoza , Genaro Gabriel Ortiz , Lorenzo Sánchez-Romero , Daniela L. C. Delgado-Lara , María T. García Martínez , Mario-Alberto Mireles-Ramírez , José Antonio Cruz Serrano , Fermín Paul Pacheco Moisés

Publicado: 2022-04-08 / http://dx.doi.org/10.20960/nh.04153
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Trabajo Original: Vitamin D levels and their association with oxidative stress and inflammation markers in patients with cystic fibrosis

Dayana Joyce Marques Queiroz , Alexandre Sérgio Silva , Celso Costa da Silva Júnior , Darlene Camati Persuhn , Alcides da Silva Diniz , Rafaela Lira Formiga Cavalcanti de Lima , Maria Paula de Paiva , Constantino Giovanni Braga Cartaxo , Patricia Gomes de Matos Bezerra , Mateus Duarte Ribeiro , Maria da Conceição Rodrigues Gonçalves

Publicado: 2022-05-23 / http://dx.doi.org/10.20960/nh.04253
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Trabajo Original: Evaluación del efecto in vitro de extractos intra y extracelulares de Lactobacillus contra la genotoxicidad y el estrés oxidativo causado por la acrilamida

Maria Goretti Reyes López , Adriana Cavazos Garduño , Nancy Elizabeth Franco Rodríguez , Jorge Manuel Silva Jara , Julio César Serrano Niño

Publicado: 2022-05-15 / http://dx.doi.org/10.20960/nh.04241
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Trabajo Original: Efecto de un multivitamínico sobre la resistencia a la insulina, inflamación y estrés oxidante en un modelo de obesidad inducida en ratas Wistar

José Antonio Palma-Jacinto , Isela Santiago-Roque , María del Rocío Coutiño-Rodríguez , Omar Elind Arroyo-Helguera

Publicado: 2023-01-31 / http://dx.doi.org/10.20960/nh.04621
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Trabajo Original: Capacidad de atrapamiento de radicales libres de la comida tradicional mexicana

María Teresa Sumaya-Martínez , Edgar Iván Jiménez-Ruiz , Marcela Robles-Machuca , Cristian Guillermo Valencia-Jurado , María Merced Romero-Chávez

Publicado: 2024-11-11 / http://dx.doi.org/10.20960/nh.05613
Resumen | PDF

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