Nutrición Hospitalaria 02763 / http://dx.doi.org/10.20960/nh.02763
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Trabajo Original

Oxidative and inflammatory effects of pulmonary rehabilitation in patients with bronchiectasis. A prospective, randomized study


Casilda Olveira, Eva García-Escobar, Esperanza Doña, Francisco J. Palenque, Nuria Porras, Antonio Dorado, Ana María Godoy, Elezahara Rubio-Martín, Francisco-Javier Bermúdez-Silva, Silvana Y. Romero-Zerbo, Gemma Rojo Martínez, Rocío Martín-Valero, José Abuín Fernández, Gabriel Olveira Fuster

Prepublicado: 2020-01-21
Publicado: 2020-02-12

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Background: systemic inflammation and oxidative stress are important factors in the pathogenesis of bronchiectasis. Pulmonary rehabilitation (PR) is recommended for bronchiectasis, but there is no data about its effect on the inflammatory and REDOX status of these patients. Aims: to investigate the effect of PR in non-cystic-fibrosis bronchiectasis (NCFB) patients, and to compare it with the effect of PR plus a hyperproteic oral nutritional supplement (PRS) enriched with beta-hydroxy-beta-methylbutyrate (HMB) on serum inflammatory and oxidative biomarkers. Materials and methods: this was an open randomized, controlled trial. Thirty individuals (65 years old or younger with a body mass index over 18.5, older than 65 years with a body mass index over 20) were recruited from September 2013 to September 2014, and randomly assigned to receive PR or PRS. Total neutrophils, and inflammatory and oxidative biomarker levels were measured at baseline, and then at 3 and 6 months. Results: in the PRS group neutrophil levels were decreased from baseline at 6 months. A significantly different fold change was found between the PR and PRS groups. In the PR group, IL-6 and adiponectin were increased by the end of the study while TNFα levels were decreased from baseline at 6 months. REDOX biomarkers remained stable throughout the study except for 8-isoprostane levels, which were increased from baseline at 6 months in both groups of patients. Conclusions: a PR program induced a pro-oxidative effect accompanied by changes in circulating inflammatory cytokine levels in NCFB patients. Our results would also suggest a possible beneficial effect of the HMB enriched supplement on neutrophil level regulation in these patients. The information provided in this study could be useful for choosing the right therapeutic approach in the management of bronchiectasis.

Palabras Clave: Bronchiectasis. Pulmonary rehabilitation. HMB (beta-hydroxy-beta-methylbutyrate). Oxidative stress. Cytokines.



Mandal P, Hill AT. Bronchiectasis: breaking the cycle of inflammation and infection. Lancet Respir Med 2013;1:e5-6.
DOI: 10.1016/S2213-2600(13)70005-5
Dente FL, Bilotta M, Bartoli ML, Bacci E, Cianchetti S, Latorre M, et al. Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis. Mediators Inflamm 2015;2015:642503.
DOI: 10.1155/2015/642503
Olveira G, Olveira C, Dorado A, Garcia-Fuentes E, Rubio E, Tinahones F, et al. Cellular and plasma oxidative stress biomarkers are raised in adults with bronchiectasis. Clin Nutr 2013;32:112–7.
DOI: 10.1016/j.clnu.2012.06.002
Park HS, Kim SR, Lee YC. Impact of oxidative stress on lung diseases. Respirology 2009;14:27–38.
DOI: 10.1111/j.1440-1843.2008.01447.x
Smith MP. Diagnosis and management of bronchiectasis. CMAJ 2017;189:E828–35.
DOI: 10.1503/cmaj.160830
Guell Rous MR, Diaz Lobato S, Rodriguez Trigo G, Morante Velez F, San Miguel M, Cejudo P, et al. Pulmonary rehabilitation. Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR). Arch Bronconeumol 2014;50:332–44.
Mandal P, Sidhu MK, Kope L, Pollock W, Stevenson LM, Pentland JL, et al. A pilot study of pulmonary rehabilitation and chest physiotherapy versus chest physiotherapy alone in bronchiectasis. Respir Med 2012;106:1647–54.
DOI: 10.1016/j.rmed.2012.08.004
van Zeller M, Mota PC, Amorim A, Viana P, Martins P, Gaspar L, et al. Pulmonary rehabilitation in patients with bronchiectasis: pulmonary function, arterial blood gases, and the 6-minute walk test. J Cardiopulm Rehabil Prev 2012;32:278–83.
DOI: 10.1097/HCR.0b013e3182631314
Lee AL, Hill CJ, Cecins N, Jenkins S, McDonald CF, Burge AT, et al. The short and long term effects of exercise training in non-cystic fibrosis bronchiectasis--a randomised controlled trial. Respir Res 2014;15:44.
DOI: 10.1186/1465-9921-15-44
Hsieh L-C, Chien S-L, Huang M-S, Tseng H-F, Chang C-K. Anti-inflammatory and anticatabolic effects of short-term beta-hydroxy-beta-methylbutyrate supplementation on chronic obstructive pulmonary disease patients in intensive care unit. Asia Pac J Clin Nutr 2006;15:544–50.
Van Koevering M, Nissen S. Oxidation of leucine and alpha-ketoisocaproate to beta-hydroxy-beta-methylbutyrate in vivo. Am J Physiol 1992;262:E27-31.
DOI: 10.1152/ajpendo.1992.262.1.E27
Cruz-Jentoft AJ. Beta-hydroxy-beta-methyl butyrate (HMB): From experimental data to clinical evidence in sarcopenia. Curr Protein Pept Sci 2017.
DOI: 10.2174/1389203718666170529105026
van Helvoort HAC, Heijdra YF, de Boer RCC, Swinkels A, Thijs HMH, Dekhuijzen PNR. Six-minute walking-induced systemic inflammation and oxidative stress in muscle-wasted COPD patients. Chest 2007;131:439–45.
DOI: 10.1378/chest.06-1655
Mercken EM, Calvert LD, Singh SJ, Hageman GJ, Schols AM, Steiner MC. Dichloroacetate modulates the oxidative stress and inflammatory response to exercise in COPD. Chest 2009;136:744–51.
DOI: 10.1378/chest.08-2890
Rodriguez DA, Kalko S, Puig-Vilanova E, Perez-Olabarria M, Falciani F, Gea J, et al. Muscle and blood redox status after exercise training in severe COPD patients. Free Radic Biol Med 2012;52:88–94.
DOI: 10.1016/j.freeradbiomed.2011.09.022
Nemoto K, Oh-Ishi S, Itoh M, Saito T, Ichiwata T. Urinary 8-hydroxydeoxyguanosine is a potential indicator for estimating pulmonary rehabilitation-induced oxidative stress in COPD patients. Tohoku J Exp Med 2014;233:197–204.
DOI: 10.1620/tjem.233.197
Olveira G, Olveira C, Dona E, Palenque FJ, Porras N, Dorado A, et al. Oral supplement enriched in HMB combined with pulmonary rehabilitation improves body composition and health related quality of life in patients with bronchiectasis (Prospective, Randomised Study). Clin Nutr 2016;35:1015–22.
DOI: 10.1016/j.clnu.2015.10.001
Doña E, Olveira C, Palenque FJ, Porras N, Dorado A, Martín-Valero R, et al. Pulmonary rehabilitation only versus with nutritional supplementation in patients with bronchiectasis: a randomized controlled trial. J Cardiopulm Rehabil Prev 2018;Jun.
DOI: 10.1097/HCR.0000000000000341
Craig CL, Marshal AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, et al. International Physical Activity Questionnaire: 12-Country Reliability and Validity. Med Sci Sport Exerc 2003;35:1381–95.
DOI: 10.1249/01.MSS.0000078924.61453.FB
Doña E, Olveira C, Palenque FJ, Dorado A, Martín-Valero R, Olveira G. The effect od pulmonary rehabilitation associated with nutritional supplementation on physical activity in patients with bronchiectasis: Randomized trial. Rev Esp Patol Torac 2017;29:167–75.
Olveira G, Olveira C, Gaspar I, Porras N, Martín-Núñez G, Rubio E, et al. Fat-free mass depletion and inflammation in patients with bronchiectasis. J Acad Nutr Diet 2012;112:1999–2006.
DOI: 10.1016/j.jand.2012.08.013
Marco E, Ramírez-Sarmiento AL, Coloma A, Sartor M, Comin-Colet J, Vila J, et al. High-intensity vs. sham inspiratory muscle training in patients with chronic heart failure: a prospective randomized trial. Eur J Heart Fail 2013;15:892–901.
DOI: 10.1093/eurjhf/hft035
Garcia-Fuentes E, Murri M, Garrido-Sanchez L, Garcia-Serrano S, García-Almeida JM, Moreno-Santos I, et al. PPARgamma expression after a high-fat meal is associated with plasma superoxide dismutase activity in morbidly obese persons. Obesity (Silver Spring) 2010;18:952–8.
DOI: 10.1038/oby.2009.314
Corp IBM. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY 2011.
Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K. Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc Immunol Rev 2002;8:6–48.
Bartlett DB, Shepherd SO, Wilson OJ, Adlan AM, Wagenmakers AJM, Shaw CS, et al. Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults. Oxid Med Cell Longev 2017;2017:8148742.
DOI: 10.1155/2017/8148742
Tenorio TRS, Balagopal PB, Andersen LB, Ritti-Dias RM, Hill JO, Lofrano-Prado MC, et al. Effect of Low- Versus High-Intensity Exercise Training on Biomarkers of Inflammation and Endothelial Dysfunction in Adolescents With Obesity: A 6-Month Randomized Exercise Intervention Study. Pediatr Exerc Sci 2017:1–10.
DOI: 10.1123/pes.2017-0067
Nunes EA, Lomax AR, Noakes PS, Miles EA, Fernandes LC, Calder PC. beta-Hydroxy-beta-methylbutyrate modifies human peripheral blood mononuclear cell proliferation and cytokine production in vitro. Nutrition 2011;27:92–9.
DOI: 10.1016/j.nut.2009.12.008
Wojcik R, Malaczewska J, Siwicki AK, Micinski J, Zwierzchowski G. The effect of beta-hydroxy-beta-methylbutyrate (HMB) on the proliferative response of blood lymphocytes and the phagocytic activity of blood monocytes and granulocytes in calves. Pol J Vet Sci 2013;16:567–9.
DOI: 10.2478/pjvs-2013-0078
van Helvoort HAC, van de Pol MHJ, Heijdra YF, Dekhuijzen PNR. Systemic inflammatory response to exhaustive exercise in patients with chronic obstructive pulmonary disease. Respir Med 2005;99:1555–67.
DOI: 10.1016/j.rmed.2005.03.028
Xie J, Yang X-Y, Shi J-D, Deng X-Q, Long W. A new inflammation marker of chronic obstructive pulmonary disease-adiponectin. World J Emerg Med 2010;1:190–5.
Townsend JR, Fragala MS, Jajtner AR, Gonzalez AM, Wells AJ, Mangine GT, et al. beta-Hydroxy-beta-methylbutyrate (HMB)-free acid attenuates circulating TNF-alpha and TNFR1 expression postresistance exercise. J Appl Physiol 2013;115:1173–82.
DOI: 10.1152/japplphysiol.00738.2013
Kraemer WJ, Hooper DR, Szivak TK, Kupchak BR, Dunn-Lewis C, Comstock BA, et al. The addition of beta-hydroxy-beta-methylbutyrate and isomaltulose to whey protein improves recovery from highly demanding resistance exercise. J Am Coll Nutr 2015;34:91–9.
DOI: 10.1080/07315724.2014.938790
Laviolette L, Lands LC, Dauletbaev N, Saey D, Milot J, Provencher S, et al. Combined effect of dietary supplementation with pressurized whey and exercise training in chronic obstructive pulmonary disease: a randomized, controlled, double-blind pilot study. J Med Food 2010;13:589–98.
DOI: 10.1089/jmf.2009.0142
Sugawara K, Takahashi H, Kashiwagura T, Yamada K, Yanagida S, Homma M, et al. Effect of anti-inflammatory supplementation with whey peptide and exercise therapy in patients with COPD. Respir Med 2012;106:1526–34.
DOI: 10.1016/j.rmed.2012.07.001
Sugawara K, Takahashi H, Kasai C, Kiyokawa N, Watanabe T, Fujii S, et al. Effects of nutritional supplementation combined with low-intensity exercise in malnourished patients with COPD. Respir Med 2010;104:1883–9.
DOI: 10.1016/j.rmed.2010.05.008
de Godoy I, Donahoe M, Calhoun WJ, Mancino J, Rogers RM. Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients. Am J Respir Crit Care Med 1996;153:633–7.
DOI: 10.1164/ajrccm.153.2.8564110
Broekhuizen R, Wouters EFM, Creutzberg EC, Schols AMWJ. Raised CRP levels mark metabolic and functional impairment in advanced COPD. Thorax 2006;61:17–22.
DOI: 10.1136/thx.2005.041996
Wood LG, Fitzgerald DA, Gibson PG, Cooper DM, Collins CE, Garg ML. Oxidative stress in cystic fibrosis: dietary and metabolic factors. J Am Coll Nutr 2001;20:157–65.
DOI: 10.1080/07315724.2001.10719028
Couillard A, Maltais F, Saey D, Debigare R, Michaud A, Koechlin C, et al. Exercise-induced quadriceps oxidative stress and peripheral muscle dysfunction in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003;167:1664–9.
DOI: 10.1164/rccm.200209-1028OC

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Trabajo Original: Factores que inciden el daño oxidativo en niños con obesidad: estudio piloto

Publicado: 2021-11-26 / http://dx.doi.org/

Trabajo Original: Purine nucleoside phosphorylase and the enzymatic antioxidant defense system in breast milk from women with different levels of arsenic exposure

Publicado: 2021-11-30 / http://dx.doi.org/

Revisión: Inflamación y obesidad (lipoinflamación)

Publicado: 2021-11-30 / http://dx.doi.org/

Trabajo Original: Reduction of serum advanced glycation end-products with a low calorie Mediterranean diet

Publicado: 2021-11-30 / http://dx.doi.org/

Trabajo Original: Fish oil and vitamin E change lipid profiles and anti-LDL-antibodies in two different ethnic groups of women transitioning through menopause

Publicado: 2021-12-01 / http://dx.doi.org/

Trabajo Original: Effect of long term intake of white tea on acute oxidative stress in rats

Publicado: 2022-01-11 / http://dx.doi.org/

Trabajo Original: Relationship between zincemia, superoxide dismutase activity and marker of oxidative stress in women with breast cancer

Publicado: 2022-01-12 / http://dx.doi.org/

Trabajo Original: Macronutrient intake is correlated with dyslipidemia and low-grade inflammation in childhood obesity but mostly in male obese

Publicado: 2022-01-12 / http://dx.doi.org/

Revisión: Potencial antioxidante de la miel de Melipona beecheii y su relación con la salud: una revisión

Publicado: 2022-01-19 / http://dx.doi.org/

Trabajo Original: Glutathione peroxidase-1 Pro200Leu polymorphism (rs1050450) is associated with morbid obesity independently of the presence of prediabetes or diabetes in women from Central Mexico

Publicado: 2022-01-19 / http://dx.doi.org/

Trabajo Original: Epitope-based vaccine for the treatment of Der f 3 allergy

Publicado: 2022-01-21 / http://dx.doi.org/

Trabajo Original: Dietary fish oil increases catalase activity in patients with probable Alzheimer’s disease

Blanca M. G. Torres-Mendoza , Genaro Gabriel Ortiz , Lorenzo Sánchez-Romero , Daniela L. C. Delgado-Lara , María T. García Martínez , Mario-Alberto Mireles-Ramírez , José Antonio Cruz Serrano , Fermín Paul Pacheco Moisés

Publicado: 2022-04-08 / http://dx.doi.org/10.20960/nh.04153

Trabajo Original: Vitamin D levels and their association with oxidative stress and inflammation markers in patients with cystic fibrosis

Dayana Joyce Marques Queiroz , Alexandre Sérgio Silva , Celso Costa da Silva Júnior , Darlene Camati Persuhn , Alcides da Silva Diniz , Rafaela Lira Formiga Cavalcanti de Lima , Maria Paula de Paiva , Constantino Giovanni Braga Cartaxo , Patricia Gomes de Matos Bezerra , Mateus Duarte Ribeiro , Maria da Conceição Rodrigues Gonçalves

Publicado: 2022-05-23 / http://dx.doi.org/10.20960/nh.04253

Trabajo Original: Evaluación del efecto in vitro de extractos intra y extracelulares de Lactobacillus contra la genotoxicidad y el estrés oxidativo causado por la acrilamida

Maria Goretti Reyes López , Adriana Cavazos Garduño , Nancy Elizabeth Franco Rodríguez , Jorge Manuel Silva Jara , Julio César Serrano Niño

Publicado: 2022-05-15 / http://dx.doi.org/10.20960/nh.04241

Trabajo Original: Efecto de un multivitamínico sobre la resistencia a la insulina, inflamación y estrés oxidante en un modelo de obesidad inducida en ratas Wistar

José Antonio Palma-Jacinto , Isela Santiago-Roque , María del Rocío Coutiño-Rodríguez , Omar Elind Arroyo-Helguera

Publicado: 2023-01-31 / http://dx.doi.org/10.20960/nh.04621

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