Nutrición Hospitalaria 03129 / http://dx.doi.org/10.20960/nh.03129

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Serum concentration of vitamin A and its relationship with body adiposity, oxidative stress, and cardiovascular risk in women with recommended dietary intake of vitamin A

Claudia Bento, Andrea Matos, Adryana Cordeiro, Andréa Ramalho

Prepublicado: 2020-10-29

Publicado: 2020-12-10

VOLUMEN 37, NÚM. 6, noviembre-diciembre (2020), PAG. 1135-1142

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Background: evidence indicates a role of vitamin A in the regulation of fat mass influencing obesity and cardiovascular diseases. Material and methods: a cross-sectional study in 200 women, paired by age and by the recommended dietary intake of vitamin A. Subjects were divided into four groups according to body mass index (BMI): 80 eutrophic (E), 40 overweight (OW), 40 class I obesity (OI) and 40 class II obesity (OII). Lipid and glycemic profiles were measured and oxidative stress was evaluated through serum concentrations of uric acid, glutathione peroxidase (GSH-Px), and thiobarbituric acid reactive substances (TBARS). Results: the cutoff points for deficiency of serum retinol and β-carotene levels were < 1.05 µmol/L and 40 µg/dL, respectively. For the recommended dietary intake of vitamin A it was 700 µg/day. Retinol and β-carotene deficiency was found in the E group at 5 % and 15 %, respectively, reaching 77.5 % and 82.5 % in the OII group. Conclusions: a correlation was observed between serum concentrations of retinol and β-carotene and glycemic, lipid, and markers of oxidative stress profiles in the groups studied. It was observed that OI and OII subjects who had retinol and β-carotene deficiency presented a risk that was 16 and 20.7 times greater, respectively, of having a diagnosis with DM2 as compared to E subjects with adequate concentrations of vitamin A. Increased demand of vitamin A may be related to increased BMI, body adiposity, and oxidative stress even when a recommended intake of vitamin A is reached.

Palabras Clave: Body adiposity. Retinol. β-carotene. Cardiovascular risks. Oxidative stress.

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Bibliografía
Artículos Relacionados

Ministério da Saúde. Sistema de Vigilância Alimentar e Nutricional (SISVAN); 2012. [Accessed March 23, 2019] Available at: http://<www.saude.gov.br/nutricao

World Health Organization (WHO). 10 Facts about obesity. Revised May of 2014. [Acessed August 24, 2018] Available at: http://www.who.int/features/factfiles/obesity/facts/en/

Redon P, Maloberti A, Facchetti R, Redon J, Lurbe E, Bombelli M, et al. Gender-related differences in serum uric acid in treated hypertensive patients from central and east European countries: findings from the Blood Pressure control rate and CArdiovascular Risk profilE study. J Hypertens 2019;37(2):380-8.
DOI: 10.1097/HJH.0000000000001908

Hoseini A, Namazi G, Farrokhian A, Reiner Z, Aghadavod E, Bahmani F, et al. The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease. Food Funct 2019;1;10(9):6042-51.
DOI: 10.1039/C9FO01075K

Raja Gopal Reddy M, Mahesh M, Manne M, Kumar Putcha U, Jeyakumar SM. Vitamin A and its metabolic pathway play a determinant role in high-fructose-induced triglyceride accumulation of the visceral adipose depot of male Wistar rats. Cell Biochem Funct2019;37(8):578-90.
DOI: 10.1002/cbf.3434

Wei X, Peng R, Cao J, Kang Y, Qu P, Liu Y, et al. Serum vitamin A status is associated with obesity and the metabolic syndrome among school-age children in Chongqing, China. Asia Pac J Clin Nutr 2016;25(3):563-70.

Bonet ML, Canas JA, Ribot J, Palou A. Carotenoids in Adipose Tissue Biology and Obesity. Subcell Biochem 2016;79:377-414.
DOI: 10.1007/978-3-319-39126-7_15

Luo H, Chiang HH, Louw M, Susanto A, Chen D. Nutrient Sensing and the Oxidative Stress Response. Trends Endocrinol Metab 2017;28(6):449-60.
DOI: 10.1016/j.tem.2017.02.008

Wang C, Ling CW, Ding D, Li YH, Cao WT, Tang XY, et al. Associations of Serum Carotenoids with DXA-Derived Body Fat and Fat Distribution in Chinese Adults: A Prospective Study. J Acad Nutr Diet 2020;120(6):985-1001.
DOI: 10.1016/j.jand.2019.12.010

OMS. Obesity: preventing and managing the global epidemic. Report of WHO consultation on obesity Geneva: World Health Organization; 1998.

Araujo MC, Verly Junior E, Junger WL, Sichieri R. Independent associations of income and education with nutrient intakes in Brazilian adults: 2008-2009 National Dietary Survey. Public Health Nutr 2014;17(12):2740-52.
DOI: 10.1017/S1368980013003005

Institute of Medicine (IOM). Vitamin A. In: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington: National Academic Press; 2001. p. 82-161.

World Health Organization (WHO) World health statistics 2011. [accessed March 22, 2014] Available at: http://www.who.int/healthinfo/statistics/en/index.html

IDF - International Diabetes Federation (2006). Arch Intern Med 2006;164:1066-76.

Arimond M, Wiesmann D, Becquey E, Carriquiry A, Daniels MC, Deitchler M, et al. Simple food group diversity indicators predict micronutrient adequacy of women’s diets in 5 diverse, resource-poor settings. J Nutr 2010;140:S2059-69.
DOI: 10.3945/jn.110.123414

Instituto de Nutrición Centro América y Panamá. Tabla de composición de alimentos para uso en America Latina; 2006. [Accessed May 19, 2013] Available at: http://www .incap.org.gt [accessed May 19, 2013]

Ministry of Agriculture, Fisheries and Food (MAFF) (1997) Food Portion Sizes. London: The Stationery Office; 1997.

WHO Consultation. Geneva, World Health Organization – WHO; 1996.

Moran NE, Mohn ES, Hason N, Erdman JW, Johnson EJ. Intrinsic and Extrinsic Factors Impacting Absorption, Metabolism, and Health Effects of Dietary Carotenoids. Adv Nutr 2018;9(4):465-92.
DOI: 10.1093/advances/nmy025

World Health Organization. Xerophthalmia and night blindness for the assessment of clinical vitamin A deficiency in individuals and populations. Vitamin and Mineral Nutrition Information System. Geneva; 2014.

Silverstein J, Klingensmith G, Copeland K, Plotnick L, Kaufman F, Laffel L, et al. Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. Diabetes Care 2005;28(1):186-212.
DOI: 10.2337/diacare.28.1.186

Nyyssonen K. Lycopene, lutein and B-carotene as determinants of LDL conjugated dienes in serum. Atherosclerosis 2010;200:565-72.

Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158-69.

Larque E. Daily intake of fruit and vegetable soups processed in different ways increases human serum B-carotene and lycopene concentrations and reduces levels of several oxidative stress markers in healthy subjects. Food Chemistry 2012;127-33.
DOI: 10.1016/j.foodchem.2012.02.078

Lee D. Relationships of Circulating Carotenoid Concentrations with Several Markers of Inflammation, Oxidative Stress, and Endothelial Dysfunction. The Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) Study. Clinical Chemistry 2007;53:447-55.
DOI: 10.1373/clinchem.2006.074930

Napoli J. HPLC/UC quantitation of retinal, retinol, and retinyl esters in serum and tissues. Analytical Biochemistry 2008;378:71-9.
DOI: 10.1016/j.ab.2008.03.038

Brazionis L, Walker KZ, Itsiopoulos C, O’Dea K. Plasma retinol: A novel marker for cardiovascular disease mortality in Australian adults. Nutrition, Metabolism & Cardiovascular Diseases 2012;22(10):914-20.
DOI: 10.1016/j.numecd.2011.08.009

Nov N. Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis. Biochim Biophys Acta 2012;1821(1):168-76.
DOI: 10.1016/j.bbalip.2011.07.002

Matos AC, Souza GG, Moreira V, Ramalho A. Effect of vitamin A supplementation on clinical evolution in patients undergoing coronary artery bypass grafting, according to serum levels of zinc. Nutr Hosp 2012;27(6):1981-6.

Santos RD, Gagliardi ACM, Xavier HT, Magnoni CD, Cassani R, Lottenberg AMP, et al. I Diretriz sobre o consumo de gorduras e saúde cardiovascular. Arq Bras Cardiol 2013;100(1 suppl. 3):1-40.
DOI: 10.5935/abc.2013S003

Schreiber R, Taschler U, Preiss-Landl K, Wongsiriroj N, Zimmermann R, Lass A. Retinyl ester hydrolases and their roles in vitamin A homeostasis. Review. Biochim Biophys Acta 2012;1821:113-23.
DOI: 10.1016/j.bbalip.2011.05.001

Bohn T. Carotenoids and Markers of Oxidative Stress in Human Observational Studies and Intervention Trials: Implications for Chronic Diseases. Antioxidants (Basel) 2019;8(6):179.
DOI: 10.3390/antiox8060179

Cheng J. Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic B cells. Molecular and Cellular Endocrinology 2013;275:89-96.

Cottone S. Absence of an independent association between serum uric acid and left ventricular mass in Caucasian hypertensive women and men. Nutrition, Metabolism & Cardiovascular Disease 2013;23:715-22.
DOI: 10.1016/j.numecd.2012.01.007

Choi WJ, Ford ES, Curhan G, Rankin JI, Choi HK. Independent association of serum retinol and beta-carotene levels with hyperuricemia: A national population study. Arthritis Care Res 2012;64:389-96.
DOI: 10.1002/acr.20692

Gong M, Wen S, Nguyen T, Wang C, Jin J, Zhou L. Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications. Diabetes Metab Syndr Obes 2020;13:943-62.
DOI: 10.2147/DMSO.S232377

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